A5023221165- Antimicrobial Peptides and Activities
- Food composition and properties
- Antimicrobial agents and applications
- Polysaccharides Composition and Applications
- Proteins in Food Systems
- Polydiacetylene-based materials and applications
- Urinary Tract Infections Management
- Microbial Metabolites in Food Biotechnology
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Dysphagia Assessment and Management
- Chemical Synthesis and Analysis
- Urinary Bladder and Prostate Research
- 3D Printing in Biomedical Research
- Surgical site infection prevention
- biodegradable polymer synthesis and properties
- Biotin and Related Studies
- Microencapsulation and Drying Processes
- Polysaccharides and Plant Cell Walls
- Antibiotic Use and Resistance
- Advanced Drug Delivery Systems
- Neuropeptides and Animal Physiology
- Antibiotic Resistance in Bacteria
- Polymer Surface Interaction Studies
- Protein Hydrolysis and Bioactive Peptides
Singapore Institute of Technology
2017-2021
Nanyang Technological University
2013-2015
Abstract Polydimethylsiloxane (PDMS) has been extensively exploited to study stem cell physiology in the field of mechanobiology and microfluidic chips due their transparency, low cost ease fabrication. However, its intrinsic high hydrophobicity renders a surface incompatible for prolonged adhesion proliferation. Plasma-treated or protein-coated PDMS shows some improvement but these strategies are often short-lived with either aggregates formation sheet dissociation. Recently, chemical...
With the rapid rise of antibiotic-resistant-device-associated infections, there has been increasing demand for an antimicrobial biomedical surface. Synthetic peptides that have excellent bactericidal potency and negligible cytotoxicity are promising targets immobilization on these target surfaces. An engineered arginine–tryptophan-rich peptide (CWR11) was developed, which displayed potent activity against a broad spectrum microbes via membrane disruption, possessed salt resistance...
Antimicrobial peptides (AMPs) kill microbes by non-specific membrane permeabilization, making them ideal templates for designing novel peptide-based antibiotics that can combat multi-drug resistant pathogens. For maximum efficacy in vivo and vitro, AMPs must be biocompatible, salt-tolerant possess broad-spectrum antimicrobial activity. These attributes obtained rational design of guided good understanding peptide structure-function. Toward this end, study investigates the influence charge...
Prevalent bacterial colonization and subsequent biofilm formation in biomedical implants demand for improved antimicrobial properties of these devices. To address this problem, immobilizing peptides (AMPs) on is a promising solution because their biocompatibility lesser likelihood to incur pathogen resistance. This study presents systematic approach towards evaluating the feasibility Lasioglossin-III (Lasio-III) (a new bee venom AMP, found Lasioglossum laticeps) be tethered onto biodevices....
Anhydrous polymers are actively explored as alternative materials to overcome limitations of conventional hydrogel-based antibacterial coating. However, the requirement for strong organic solvent in polymerization reactions often necessitates extra protection steps encapsulation target biomolecules, lowering efficiency, and increasing process complexity. This study reports a novel coating strategy that allows direct solvation antimicrobial peptides (HHC36) into anhydrous polycaprolactone...
Catheter-associated urinary tract infections (CAUTIs) are common and pose significant costs to healthcare systems. To date, this problem is largely unsolved as commercially available antimicrobial catheters still lacking in functionality performance. A prior study by Lim et al. ( Biotechnol. Bioeng. 2018, 115 (8), 2000-2012) reported the development of a novel anhydrous polycaprolactone (PCL) polymer formulation with controlled-release for peptides. In follow-up study, we developed an...
The use of alcohol-based sanitizers has been recommended as an effective alternative to clean hands, especially in the case when hand washing is not doable. This critical with COVID-19 pandemic, where personal hygiene important factor deter spread virus. study assesses and evaluates differences antibacterial efficacy functionalities five different commercial formulations. All were able provide instant sanitization functionality, effectively killing 5x10 5 CFU/mL inoculated bacteria. However,...
This study focuses on understanding the effect of ionic strength mechanical and microstructural properties novel composite gels containing 13% whey protein isolate (WPI) 4% de-structured waxy potato starch (DWPS). The DWPS is a physically modified treated at 140 °C for 30 min under constant shear. Thermodynamic incompatibility between WPI was observed upon addition NaCl (~75 mM) or CaCl2 (10-75 mM). combined effects such thermodynamic with changes in connectivity induced by varied led to...
Rice starch is a common functional ingredient used in various food applications. The drying regime to obtain dry powder an important processing step, which affects the properties of starch. application extreme thermal treatment during conventional process tends elicit irreversible changes rice starch, resulting loss desired functionalities. In previous study, we reported development novel low temperature spray-drying based efficiently dries waxy while preserving its physicochemical and This...
White bread contains a high proportion of easily digestible starch, which contributes to an undesirable rapid increase in blood glucose concentration. This study investigated the effects nonstarch polysaccharides (NSP) -xanthan gum, lambda-carrageenan and psyllium husk on physical functionality glycaemic potency white bread. The amount water for each formulation was adjusted based DoughLab set at target torque value ~500 FU sufficient dough development. Adding NSP generally resulted...
Rice starch is an important functional ingredient for various food applications. As such, it that physicochemical functionalities of rice are not adversely affected during the extraction and drying process. This report looks at development a low-temperature spray process production native starch. Using waxy as candidate, reported strategy produced starches with relatively high yield (74.13%), low moisture (13.92%) uniform particle size. Physicochemical functionalities, including...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to "Immobilization Studies of an Engineered Arginine-Tryptophan Rich Peptide on Silicone Surface with Antimicrobial and Antibiofilm Activity"Kaiyang Lim, Ray Rong Yuan Chua, Rathi Saravanan, Anindya Basu, Biswajit Mishra, Paul Anantharajah Tambyah, Bow Ho, Susanna Su Jan Leong*Cite this: ACS Appl. Mater. Interfaces 2013, 5, 17, 8821Publication Date (Web):August 22, 2013Publication...