A5073196362- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Infections and bacterial resistance
- Protein Degradation and Inhibitors
- Cardiovascular Function and Risk Factors
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Pneumonia and Respiratory Infections
- Heparin-Induced Thrombocytopenia and Thrombosis
- Elasticity and Material Modeling
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- Full-Duplex Wireless Communications
- Vaccine Coverage and Hesitancy
- Autoimmune and Inflammatory Disorders Research
- Toxoplasma gondii Research Studies
- Vibrio bacteria research studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ear and Head Tumors
- Hepatitis B Virus Studies
- Multiple Myeloma Research and Treatments
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2021-2023
Zhejiang University
2019-2023
First Affiliated Hospital Zhejiang University
2020-2023
Jinhua Central Hospital
2019-2022
National Clinical Research Center for Digestive Diseases
2022
Sir Run Run Shaw Hospital
2019
Sun Yat-sen Memorial Hospital
2015
Sun Yat-sen University
2015
Hepatitis B virus (HBV) infection is a well-recognized occupational risk for health care workers (HCWs). Vaccination coverage, disease trends, and the need booster doses after hepatitis vaccination of adults have been subject intense study during 15 years vaccine's availability.Vaccination coverage HCWs was determined from review medical records on sample employees 113 randomly selected hospitals. The number HBV infections among general US population 1983 through 1995 estimated national...
Bacteremia caused by carbapenem-resistant Pseudomonas aeruginosa (CRPA) has high mortality, threatening the healthcare quality worldwide. Analysis is required to update epidemiological data of CRPA bloodstream infections (BSI) and evaluate prevalent strains in China. Moreover, it necessary clarify risk factors associated with development mortality bacteremia.This a 9-year multicenter retrospective study, enrolling 137 patients BSI carbapenem-susceptible P. (CSPA) during January 2012 December...
The aim was to examine the clinical characteristics and risk factors for bloodstream infection (BSI) due carbapenem-resistant Klebsiella pneumoniae (CRKP) in patients with hematologic malignancies.A single-centre, retrospective case-control study representing 734 malignancies between January 1, 2017, December 31, 2018, conducted. Demographic data were collected from hospital electronic medical records system.Among malignancies, 3% (22/734) of developed CRKP BSI during their hospitalization....
To describe the clinical and molecular characteristics of β-lactam/β-lactamase inhibitor combinations (BLBLIs) non-susceptible ESBL-producing Enterobacteriaceae (BnESBL-E) bloodstream infections (BSIs). A cohort study was performed with ESBL-E-BSI cases from 2017 to 2019 in East China. Clinical characteristics, risk factors, all-course mortality were evaluated. Whole-genome sequencing antibiotic susceptibility testing performed. Among 187 patients ESBL-E-BSI, 39.57% (74/187) had...
Recently, KPC-producing P. aeruginosa has rapidly emerged and expanded in East China. Here we described the clinical impact characteristics of bloodstream infections (BSIs) from dominant CRPA belonging to Sequence Type (ST) 463.Retrospective cohort study was performed with BSI cases 2019 2020 a hospital Clinical characteristics, risk factors, all-course mortality were evaluated. All isolates had whole-genome sequencing, antimicrobial susceptibility testing, serum resistance assay....
The aim of this study was to investigate the clinical and microbiological features community-onset CRE (CO-CRE) obtained from outpatients at a tertiary hospital in China.We isolated 64 strains divided them into three groups: 36 hospital-acquired (HA-CRE), 28 CO-CRE including 15 community-acquired (CA-CRE) 13 healthcare-associated (HCA-CRE). Clinical information collected. antibiotic susceptibilities were tested. Whole-genome sequencing (WGS) conducted, then drug resistance gene analysis...
Post-operative central nervous system infections (PCNSIs) caused by carbapenem-resistant Enterobacteriaceae (CRE) frequently result in unfavorable outcomes. However, CRE PCNSIs have not been well described from a clinical and microbiological perspective. A total of 254 cases were included (Jan.2017-Jun.2020), features compared based on pathogenic classification. Cox regression analysis was performed to assess risk factors for mortality. Antibiotic susceptibility testing whole genome...
Objective: Critical patients in intensive care unit (ICU) are highly susceptible to acquiring carbapenem-resistant Acinetobacter baumannii (CRAB) infection. To investigate the relationship between nosocomial infections and environmental health, we studied distribution homology of CRAB isolates from environment evaluated effectiveness infection control measures. Methods: In 4-month study, conducted a monthly screening ICU prior disinfection Chinese teaching hospital. The underwent routine...
Objective: To summarize the radiological and clinical features of radiation-induced external auditory canal carcinomas (RIEACCs) in patients with nasopharyngeal (NPCs) after radiation therapy. Methods: CT, MRI 16 histologically proven RIEACCs were retrospectively reviewed. There 2 females 14 males, a median age 52.5 years at time diagnosis RIEACC. Imaging parameters including lesion extent, size, margin, shape, bone destruction, adjacent structure invasion, density/signal intensity, pattern...
Background: Hepatitis B virus (HBV) and the associated cirrhosis are risk factors for cryptococcal meningitis (CM). However, clinical features of co-infection with HBV CM unclear.Methods: Seventy-nine HBV-infected patients 79 HBV-uninfected were enrolled in a case-control matching study from 476 patients. Fibrosis 4 index (FIB4) was used assessment HBV-related fibrosis/cirrhosis. Demographic characteristics, symptoms, routine blood tests, liver function cerebrospinal fluid (CSF) profiles...
Abstract Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) associated infections are a major threat to patient safety. Methods: A single-center, retrospective case-control study representing 734 patients with hematologic malignancies between January 1, 2017 and December 31, 2018 was conducted. Demographic clinical data were collected from the hospital electronic medical records system. Results: Among malignancies, 3% (22/734) of developed CRKP BSI during their hospitalization....
Background: Research has showed histone deacetylase (HDAC) is overexpressed in plasma cells. Panobinostat was the first HDAC inhibitor (HDACi) approved by FDA for patients with relapse and refractory multiple myeloma (RRMM) 2015. Chidamide an oral subtype-selective HDACi, independently developed China peripheral T-cell lymphoma. Preclinical findings have demonstrated anti-myeloma activities of chidamide vitro vivo. Aims: Here we report initial efficacy safety this prospective, phase IIa,...
A retrospective analysis of 7 patients multiple myeloma (MM) with initial manifestation bleeding and coagulation abnormalities were performed. Clinical manifestations, laboratory imaging examinations collected. The activity factors was measured before the treatment. Single factor X deficiency seen in one patient. Two cases had Ⅶ deficiency, while four other deficiency. time from onset symptoms to diagnosis ranged 2 10 months. After anti-MM treatment started plasma or transfused, prolonged...