A5010273437- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Organ Donation and Transplantation
- Systemic Lupus Erythematosus Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Kidney Injury Research
- Complement system in diseases
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Neurological Complications and Syndromes
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Genetic and Kidney Cyst Diseases
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Erythropoietin and Anemia Treatment
- Mycobacterium research and diagnosis
- Iron Metabolism and Disorders
Post Graduate Institute of Medical Education and Research
2016-2025
Creative Commons
2023
Safdarjang Hospital
2023
NHS Lanarkshire
1994-2021
National Cancer Registry
2019
Kidney Health Australia
2019
Zhaotong University
2019
Public Health Scotland
1995-2017
University of Glasgow
1990-2017
Healthcare Improvement Scotland
2003-2009
Idiopathic membranous nephropathy (IMN) is the most common cause of nephrotic syndrome in adults. Universal consensus regarding need for and modality therapy has not been formed because a lack controlled trials sufficient size, quality, duration. This study compared effect 6-mo course alternating prednisolone cyclophosphamide with supportive treatment adults caused by IMN on doubling serum creatinine, development ESRD, quality life randomized, trial. Patients were followed up 10 yr. Data...
There have been very few studies comparing cyclophosphamide (CTX) and calcineurin inhibitor based regimens in the management of non-immunosuppressive symptomatic therapy (NIST) resistant idiopathic membranous nephropathy (IMN). The present study was aimed at efficacy safety tacrolimus (TAC)/steroids with cyclical CTX/steroids (Modified Ponticelli regimen (MPR)) patients IMN.Idiopathic (n = 70) persistent nephrotic syndrome after least 6 months antiproteinuric or complications were equally...
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has affected the care of patients with noncommunicable diseases, including those suffering from kidney-related ailments. Many parts world, India, adopted lockdown to curb community transmission disease. The transportation, access health facilities, and availability medicines consumables as well outpatient inpatient services. We aimed analyze effect imposed due COVID-19 on kidney diseases in India.MethodsWe surveyed 19 major...
Background. Elderly individuals need a host of diagnostic procedures and therapeutic interventions to take care ailments. This prospective study was carried out determine the magnitude treatment-related acute renal failure (ARF) in elderly hospital setting, know about pathogenetic factors that could predict an adverse outcome.
Antibodies to M-type phospholipase A2 receptor (PLA2R) correlate with clinical activity of primary membranous nephropathy (PMN). Risk alleles in PLA2R1 and HLA-DQA1 genes are associated PMN. Whether these the development anti-PLA2R is unknown. In this prospective study we evaluated anti-PLA2R, enhanced glomerular staining for PLA2R variations Indian patients PMN examined their association response treatment.A total 114 adult were studied. Anti-PLA2R was estimated before treatment after 6 12...
The current treatment regimes for patients with nephrotic syndrome due to idiopathic membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS) are based on steroids and/or cytotoxic agents. Data the effect of mycophenolate mofetil (MMF) these conditions scarce confounding.We compared efficacy an MMF-based therapy standard therapies in inducing remission adult nephrotics MN FSGS a randomized pilot study. MMF was given at 2 g/day 6 months along prednisolone 0.5 mg/kg/day 2-3...
Journal Article Inappropriate use of the term ‘Asian’: an obstacle to ethnicity and health research Get access R. S. Bhopal, Bhopal Professor Epidemiology Public Health Division Health, The Medical School, Framlington PlaceNewcastle upon Tyne NE2 4HH Adress correspondence Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Phillimore, Phillimore Senior Research Associate Centre Urban Regional Development Studies University Newcastle TyneNewcastle H. Kohli...
Identification of pathological events in the renal allograft using protocol biopsies at predetermined time intervals may yield useful information and improve outcomes. We examined influence decisions taken on basis 1- 3-month findings 1-year function a prospective randomized study. Out 102 living-donor recipients, 52 were to undergo 50 controls had only indicated biopsies. All acute rejection (AR) episodes (clinical subclinical) treated. Calcineurin inhibitor (CNI) dose adjustments made...
Background Inflammatory cytokine genes have been proposed as good candidate for conferring susceptibility to diabetic nephropathy. In the present study, we examined combined effect of multiple alleles pro inflammatory determining risk nephropathy in type 2 patients. Methodology/Principal Findings Eight single nucleotide polymorphisms (SNPs) pro-inflammatory (CCL2, TGFB1, IL8, CCR5, and MMP9) were genotyped two independently ascertained cohorts with (DN) without (DM); consisting patients from...
IntroductionBoth cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report patients randomized to receive TAC/GCs or at 2 years post randomization.MethodsSeventy enrolled clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen Treatment Idiopathic Membranous Nephropathy: Randomized Control Trial were followed quarterly between 12 24 months. At end months, 3 lost follow-up.ResultsAt 18 66% 89% (P...
Renal involvement in 204 cases with multiple myeloma admitted over a 10-year period to this tertiary care center north India was retrospectively examined. occurred 55 (27%); the vast majority of whom (94.5%) had presented renal failure and 7.3% nephrotic syndrome. The diagnosis made after admission 51 (92.7%) cases. Oliguria seen 23.6% two-third patients required dialysis. Factors precipitating were identified 53% included dehydration (33%), hypercalcemia (24%), nephrotoxic drugs (16%),...
Summary This study assesses the economic benefits of misoprostol in prophylaxis gastric ulcers larger than 0.3 cm patients with osteoarthritis receiving non-steroidal anti-inflammatory drugs. Independent epidemiological data were obtained for Scotland and West Midlands. Co-diagnosis arthritis ulcer recorded routine was substantially less (4% Scotland, 10% Midlands) 21% found at case review. These combined cost patient management a decision analysis model to explore whether prophylactic use...
Background. Cutaneous sensitivity to the tuberculin antigen is thought indicate latent tuberculosis infection (LTBI). Some guidelines suggest treating end-stage renal disease (ESRD) patients for LTBI on basis of positivity. The prevalence and cutaneous anergy in Indian with ESRD utility test predicting post-transplant are not known. Methods. We prospectively studied reactivity 108 100 age- sex-matched healthy controls. Mumps tetanus toxoid were used as control antigens. Patients who failed...
Genetic predisposition has been proposed to be a major determinant in the development of renal complications diabetes. Among candidate genes examined for susceptibility diabetic nephropathy, angiotensin-converting enzyme (ACE) gene found associated with pathogenesis and progression nephropathy. However, role other renin-angiotensin system (RAS) polymorphisms their possible interactions different ACE I/D genotypes are less clearly defined. Recent studies also show that haplotypes may better...
Glomerular diseases are an important cause of chronic renal failure in developing countries. The spectrum causing nephrotic syndrome is changing globally the last few decades. aim this prospective study was to look at a tertiary care center North India and analyze trends over five Patients age group 18-60 years with were consecutively included study. Renal biopsies performed all patients subjected light microscopy, immunofluorescence (IF) electron microscopy (EM). While IF 78% cases, EM...
Invasive zygomycosis (mucormycosis) occurs predominantly in immunocompromised patients whom it carries a grave prognosis. While renal involvement is not so uncommon disseminated infection, isolated rare.Forty-five with systemic were seen over 12-year period from January 1986 to December 1997. Among these, 18 had involvement, nine disease and zygomycosis. No underlying predisposing was identified the majority of (72%). Renal confirmed at autopsy 13 by ante-mortem biopsy five patients. The...