A5000721144- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Cancer Research and Treatments
- Pluripotent Stem Cells Research
- interferon and immune responses
- 14-3-3 protein interactions
- Epigenetics and DNA Methylation
- RNA Research and Splicing
Centre for Genomic Regulation
2022-2024
Embryo size, specification, and homeostasis are regulated by a complex gene regulatory signaling network. Here we used expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse engineer an mESC We identify NKX1-2 as novel master regulator preimplantation embryo development. find that Nkx1-2 inhibition reduces nascent RNA synthesis, downregulates genes controlling ribosome biogenesis, translation, transport, induces severe alteration nucleolus structure,...
Abstract Triple‐negative breast cancer (TNBC) often develops resistance to single‐agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 synergistically limits TNBC proliferation in vitro vivo . Mechanistically, interacts nucleus with short isoform (BRD4S), MED1, cell cycle transcriptional regulator B‐MyB. These interactions sustain formation MED1 nuclear foci control progression at gene...
SUMMARY Metastasis is responsible for nearly 90% of all cancer-related deaths. Despite global efforts to prevent aggressive tumours, cancers such as pancreatic ductal adenocarcinoma (PDAC) are poorly diagnosed in the primary stage, resulting lethal metastatic disease. RAS mutations known promote tumour spread, with mutant KRAS present up cases. Until recently, remained untargeted and, despite recent development inhibitors, results show that cells develop resistance. Another strategy...
Abstract Triple-negative breast cancer often develops resistance to single-agent treatments, which can be circumvented with targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 cooperate reduce triple-negative proliferation in vitro vivo . Mechanistically, reveal interacts nucleus short isoform MED1 control cell cycle progression at gene expression level via sustaining formation BRD4-MED1 nuclear transcriptional foci. Indeed,...