A5058856982- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Fibroblast Growth Factor Research
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Soft tissue tumor case studies
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- IgG4-Related and Inflammatory Diseases
- Protein Degradation and Inhibitors
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Bone health and treatments
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Osteoarthritis Treatment and Mechanisms
- Bone and Dental Protein Studies
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- S100 Proteins and Annexins
- Gallbladder and Bile Duct Disorders
Vall d'Hebron Institut de Recerca
2022-2025
Vall d'Hebron Institute of Oncology
2020-2025
Vall d'Hebron Hospital Universitari
2023-2025
Institute of Science and Technology
2017-2023
Universitat Pompeu Fabra
2017-2023
Hebron University
2020-2023
Centre for Genomic Regulation
2017-2023
Centre National de la Recherche Scientifique
2009-2018
Institut Pasteur de Lille
2009-2018
Université de Lille
2009-2018
Enhancer activity drives cell differentiation and fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation transdifferentiation of human leukemia B-cells to macrophages. Putative are established by binding the pioneer factor C/EBPα followed chromatin opening RNA (eRNA) synthesis from H3K4-monomethylated regions. Using eRNA as a proxy for activity, find that most putative in an additive way regulate transcription...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, chromatin remodeling, pancreatic tumors progression becoming increasingly recognized. Moreover, PDAC these aberrant mechanisms can also limit therapy efficacy. This study aimed to investigate the expression prognostic significance key complex...
Abstract The human transcriptome contains thousands of small open reading frames (sORFs) that encode microproteins whose functions remain largely unexplored. Here, we show TINCR lncRNA encodes pTINCR, an evolutionary conserved ubiquitin-like protein (UBL) expressed in many epithelia and upregulated upon differentiation under cellular stress. By gain- loss-of-function studies, demonstrate pTINCR is a key inducer epithelial vitro vivo. Interestingly, low expression associates with worse...
Abstract Purpose: FGFR2 fusions occur in 10% to 15% of patients with intrahepatic cholangiocarcinoma (iCCA), potentially benefiting from FGFR inhibitors (FGFRi). We aimed assess the feasibility detecting plasma and explore biomarkers for managing FGFRi treatment. Experimental Design: conducted a retrospective study 18 iCCA known previously identified tissue samples prior Both synchronous were analyzed using custom hybrid capture gene panel next-generation sequencing (VHIO-iCCA panel)...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive bile duct malignancy that frequently exhibits isocitrate dehydrogenase (
Reprogramming of cellular identity using exogenous expression transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, regenerative medicine. However, generation desired cell types this approach often plagued by inefficiency, slow conversion, an inability to produce mature functional cells. Here, we show that constitutively active SMAD2/3 significantly improves the efficiency induced pluripotent stem (iPSC) Yamanaka factors. Mechanistically, SMAD3...
494 Background: The mutational landscape of GEA is rapidly evolving with the identification promising molecular targets. However, histological subtypes are insufficient to capture heterogeneity in these patients (pts). We aim assess histopathological and features a cohort using NGS techniques, evaluate frequency its prognostic correlation. Methods: conducted retrospective study on from 2019 2024. Immunohistochemistry (IHC) was used HER2 expression, microsatellite instability (MSI),...
Abstract Background: NUT carcinoma (NC) is a rare, aggressive tumor with poor prognosis and no standard treatment. NC arises from NUTM1 gene rearrangements, which drive epigenetic dysregulation uncontrolled proliferation via enhanced RNA polymerase II (RNA-pol II) activity. An analysis of our registry (70 patient) revealed limited benefits current systemic therapies. Among patients on first-line (26), progression-free survival was modest: immunotherapy (5.4months-mo-, 95%CI 3.6-7.1),...
Ampullary carcinoma (AC) is a rare disease with an abysmal prognosis and few treatment options. The molecular landscape its therapeutic implications remain inadequately understood. This study aims to provide clinical genomic characterization of AC explore opportunities for precision oncology. We carried out retrospective analysis features in patients treated our institution. Gene mutations were categorized into pathways, potentially targetable alterations classified according the European...
Osteopontin (OPN) is an extracellular matrix glycophosphoprotein that plays a key role in the metastasis of wide variety cancers. The high level OPN expression prostate cells associated with malignancy and reduced survival patient. Recent studies on cancer (PCa) tissue have revealed recurrent genomic rearrangements involving fusion 5' untranslated region prostate-specific androgen-responsive gene coding for transcription factors from ETS family. most frequently identified TMPRSS2:ERG, which...
Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1, and BRCA1/2 have been identified 30%-50% of patients CCA. Several types tumor cells harboring these exhibit homologous recombination deficiency (HRD) phenotype enhanced sensitivity PARP inhibitors (PARPi). However, PARPi treatment has not yet...
Abstract Triple‐negative breast cancer (TNBC) often develops resistance to single‐agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 synergistically limits TNBC proliferation in vitro vivo . Mechanistically, interacts nucleus with short isoform (BRD4S), MED1, cell cycle transcriptional regulator B‐MyB. These interactions sustain formation MED1 nuclear foci control progression at gene...
ΔNp63α is a critical mediator of epithelial development and stem cell function in variety tissues including the skin breast, while overexpression acts as an oncogene to drive tumor formation cancer properties squamous carcinoma. However, with regards prostate, expressed basal cells mature gland, during adenocarcinoma development, its expression lost absence used clinically diagnose malignant state. Surprisingly, here we identify sub-population bone metastatic prostate PC3 line that express...
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how Il6 expression is regulated and whether it plays a role during embryo development remains unknown. Here, we describe that necessary C/EBPα-enhanced of B iPSCs but not macrophage transdifferentiation. C/EBPα overexpression activates both Il6ra genes in PSCs. In development, Cebpa enriched the trophectoderm blastocysts together with Il6, while mostly expressed inner mass...