Infrared (IR) modalities represent the only currently viable mass fever screening approaches for outbreaks of infectious disease pandemics such as Ebola virus and severe acute respiratory syndrome. Non-contact IR thermometers (NCITs) thermographs (IRTs) have been used in public areas airports. While NCITs remain a more popular choice than IRTs, there has increasing evidences literature that IRTs can provide great accuracy estimating body temperature if qualified systems are appropriate...

Significance: Infrared thermographs (IRTs) have been used for fever screening during infectious disease epidemics, including severe acute respiratory syndrome, Ebola virus disease, and coronavirus 2019 (COVID-19). Although IRTs significant potential human body temperature measurement, the literature indicates inconsistent diagnostic performance, possibly due to wide variations in implemented methodology. A standardized method IRT was recently published, but there is a lack of clinical data...

Infrared thermographs (IRTs) implemented according to standardized best practices have shown strong potential for detecting elevated body temperatures (EBT), which may be useful in clinical settings and during infectious disease epidemics. However, optimal IRT calibration methods not been established the performance of these devices relative more common non-contact infrared thermometers (NCITs) remains unclear. In addition confirming findings our preliminary analysis study results, primary...

The emerging technique of rapid prototyping with three-dimensional (3-D) printers provides a simple yet revolutionary method for fabricating objects arbitrary geometry. use 3-D printing generating morphologically biomimetic tissue phantoms based on medical images represents potentially major advance over existing phantom approaches. Toward the goal image-defined phantoms, we converted segmented fundus image human retina into matrix format and edited it to achieve geometry suitable printing....

Emerging three-dimensional (3D) printing technology enables the fabrication of optically realistic and morphologically complex tissue-simulating phantoms for development evaluation novel optical imaging products. In this study, we assess potential to print image-defined neurovascular with patent channels contrast-enhanced near-infrared fluorescence (NIRF) imaging. An anatomical map defined from clinical magnetic resonance (MRI) was segmented processed into files suitable a forebrain vessel...

Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from analysis roughness. For this purpose, we developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential neoplasia based a roughness assessment epidermis. The system was study rough surface scattering wax...

Using a validated swine model of human scar formation, hyperpigmented and hypopigmented samples were examined for their histological optical properties to help elucidate the mechanisms characteristics dyspigmentation. Full-thickness wounds created on flanks red Duroc pigs allowed heal. Biopsies from areas hyperpigmentation, hypopigmentation, uninjured tissue fixed embedded examination using Azure B primary antibodies S100B, HMB45, α-melanocyte-stimulating hormone (α-MSH). Spatial frequency...

Fever screening based on infrared (IR) thermographs (IRTs) is an approach that has been implemented during infectious disease pandemics, such as Ebola and Severe Acute Respiratory Syndrome. A recently published international standard indicates regions medially adjacent to the inner canthi provide accurate estimates of core body temperature are preferred sites for fever screening. Therefore, rapid, automated identification within facial IR images may greatly facilitate rapid asymptomatic...

Infrared thermographs (IRTs) are commonly used during disease pandemics to screen individuals with elevated body temperature (EBT). To address the limited research on external factors affecting IRT accuracy, we conducted benchtop measurements and computer simulations two IRTs, or without an reference source (ETRS) for compensation. The combination of ETRS forms a screening thermograph (ST). We investigated effects viewing angle (θ, 0-75°), set (TETRS, 30-40 °C), ambient (Tatm, 18-32 relative...

We have investigated the potential for contrast-enhanced near-infrared fluorescence imaging of tissue on a mobile phone platform. Charge-coupled device- and phone-based cameras were used to image molded three-dimensional-printed phantoms, an ex vivo animal model. Quantitative qualitative evaluations quality demonstrate viability this approach elucidate variations in performance due wavelength, pixel color, processing.

Hypertrophic scars (HTS) are a pathologic reaction of the skin and soft tissue to burn or other traumatic injury. Scar can cause patients serious functional cosmetic issues. management strategies, specifically scar assessment techniques, vital improve clinical outcome. To date, no entirely objective method for has been embraced by medical community. In this study, we introduce first time, novel polarized multispectral imaging system combining out-of-plane Stokes polarimetry Spatial Frequency...

Purpose Near‐infrared fluorescence (NIRF) imaging using exogenous contrast has gained much attention as a technique for enhancing visualization of vasculature untargeted agents, well the detection and localization cancer with targeted agents. In order to address emerging need standardization NIRF technologies, it is necessary identify best practices suitable objective, quantitative testing key image quality characteristics. Toward development battery test methods that are rigorous yet...

The duroc pig has been described as a promising animal model for use in the study of human wound healing and scar formation. However, little is known about presence chronology fibrocyte cell population process these animals. Wounds to form were created on red swine (3" x 3") with dermatome total depth either 0.06 inches or 0.09 inches. These wounds allowed heal completely biopsies done at scheduled time points during process. Biopsies formalin fixed paraffin embedded immunohistochemical...

A study of polarized light transport in scattering media exhibiting directional anisotropy or linear birefringence is presented this paper. Novel theoretical and experimental methodologies for the quantification birefringent alignment based on out‐of‐plane are here. Monte Carlo model a polarimetric imaging system were devised to predict measure impact an impinging linearly beam. Ex‐vivo experiments conducted bovine tendon, biological sample consisting highly packed type I collagen fibers...

Compression therapy has long been a standard treatment for hypertrophic scar prevention. However, due to the lack of objective, quantitative assessments, and measurements severity, as well self-operated, controllable, precise pressure delivery technique, limited concrete evidence exists, demonstrating compression therapy's efficacy. We have designed built an automatic system apply maintain constant on tissue in animal model. A force sensor positioned plate reads imposed real-time sends...

Dermoscopy is one of the major imaging modalities used in diagnosis skin lesions such as melanoma and other pigmented lesions. Due to difficulty subjectivity human interpretation, computerized analysis dermoscopy images has become an important research area. One most steps image automated detection lesion borders. In this paper we propose a novel approach for border images. First, color input converted into gray-level image. Then, wavelet coefficients are calculated. The modified using...

Cerebral oximetry based on near-infrared spectroscopy represents a unique noninvasive tool for real-time surgical monitoring, yet studies have shown significant discrepancy in accuracy among commercial systems. Towards the establishment of standardized method performance testing, we studied solid phantom approach - 3D-printed cerebrovascular module (CVM) incorporating an array 148 cylindrical channels that has several advantages over liquid phantoms. Development and characterization CVM...

The emerging technique of three-dimensional (3D) printing provides a revolutionary way to fabricate objects with biologically realistic geometries. Previously we have performed optical and morphological characterization basic 3D printed tissue-simulating phantoms found them suitable for use in evaluating biophotonic imaging systems. In this study assess the potential irregular, image-defined vascular networks that can be used provide clinically-relevant insights into device performance. A...

Scarring can lead to significant cosmetic, psychosocial, and functional consequences in patients with hypertrophic scars from burn trauma injuries. Therefore, quantitative assessment of scar is needed clinical diagnosis treatment. The Vancouver Scar Scale (VSS), the accepted tool, was introduced nineties relies only on physician subjective evaluation skin pliability, height, vascularity, pigmentation. To date, no entirely objective method has been available for assessment. So, there a...

Thermal modalities represent the only currently viable mass fever screening approach for outbreaks of infectious disease pandemics such as Ebola and SARS. Non-contact infrared thermometers (NCITs) thermographs (IRTs) have been previously used in transportation hubs airports to reduce spread disease. While NCITs remain a more popular choice field at fixed locations, there has increasing evidence literature that IRTs can provide greater accuracy estimating core body temperature if appropriate...

Hyperspectral reflectance imaging (HRI) is an emerging clinical tool for characterizing spatial and temporal variations in blood perfusion oxygenation applications such as burn assessment, wound healing, retinal exams intraoperative tissue viability assessment. Since HRI-based oximeters often use near-infrared (NIR) light, NIR-enabled mobile phones may provide a useful platform future point-of-care devices. Furthermore, quantitative NIR on dramatically increase the availability accessibility...