A5038616030- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neural Engineering
- Ion Channels and Receptors
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Vestibular and auditory disorders
- Muscle Physiology and Disorders
- Zebrafish Biomedical Research Applications
- Visual perception and processing mechanisms
- Marine Invertebrate Physiology and Ecology
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Venomous Animal Envenomation and Studies
- Chemical and Physical Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Migraine and Headache Studies
- Sleep and Wakefulness Research
- Genetic Neurodegenerative Diseases
National Center for Complementary and Integrative Health
2017-2025
National Institutes of Health
2017-2020
University of Wisconsin–Madison
2012-2016
University of Virginia
2009-2012
Janelia Research Campus
2007
Howard Hughes Medical Institute
2007
The stretch-gated ion channel PIEZO2 is required for inflammation-induced tactile allodynia.
Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and cells. After CSD, ~11% of CSF proteome altered, up-regulation proteins directly...
Genetically encoded voltage sensors expand the optogenetics toolkit into important realm of electrical recording, enabling researchers to study dynamic activity complex neural circuits in real time. However, these probes have thus far performed poorly when tested intact circuits. Hybrid (hVOS) enable imaging by harnessing resonant energy transfer that occurs between a genetically component, membrane-tethered fluorescent protein serves as donor, and small charged molecule, dipicrylamine,...
Neural circuits that translate sensory information into motor commands are organized in a feedforward manner converting output. The superior colliculus (SC) follows this pattern as it plays role visual from the retina and cortex for rapid eye movements (saccades). Feedback movement to regions is hypothesized play critical roles attention, image stability, saccadic suppression, but contrast pathways, feedback has received much less attention. present study used voltage imaging patch-clamp...
Abstract The sensation of pressure allows us to feel sustained compression and body strain. While our understanding cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations patients with rare disorders, as well nerve blocks typical individuals, probe the neural genetic mechanisms for detecting non-painful pressure. We show that ability perceive innocuous pressures is lost when myelinated...
Abstract Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative that caused by the expansion of a polyglutamine (polyQ) stretch within Huntingtin (htt), protein product HD gene. Although studies in vitro have suggested mutant htt can act potentially negative fashion sequestering wild-type into insoluble aggregates, role length normal polyQ stretch, and adjacent proline-rich region (PRR) modulating mouse model pathogenesis currently unknown. Results We describe...
The mammalian superior colliculus (SC) is a laminar midbrain structure that translates visual signals into commands to shift the focus of attention and gaze. SC plays an integral role in selecting targets ultimately generating rapid eye movements those targets. In all mammals studied date, neurons are arranged topographically such location stimuli endpoints orienting form organized maps superficial deeper layers, respectively. organization these thought underlie attentional priority by...
The mammalian superior colliculus (SC) is a midbrain structure that integrates multimodal sensory inputs and computes commands to initiate rapid eye movements. SC neurons burst with the sudden onset of visual stimulus, followed by persistent activity may underlie shifts attention decision making. Experiments in vitro suggest circuit reverberations play role SC, but origin unclear. In present study we characterized an afterdepolarization (ADP) follows action potentials slices rat SC....
Abstract The Hox family of transcription factors are expressed at different domains along the rostrocaudal (R‐C) body axis during development. To examine function Hoxc8 and Hoxc9 in specific cell types developmental times, we have generated characterized loxP flanked (floxed) Hoxc8→Hoxc9 replacement alleles mice, with either GFP or LacZ reporters. Although all four mice behave like wild‐type controls motor behavioral testing, slight differences endogenous gene expression were observed among...