A5103273988- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- TGF-β signaling in diseases
- Developmental Biology and Gene Regulation
- Electrocatalysts for Energy Conversion
- Pluripotent Stem Cells Research
- Quality and Supply Management
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Fuel Cells and Related Materials
- Computational Drug Discovery Methods
- Landslides and related hazards
- Photoacoustic and Ultrasonic Imaging
- Sustainable Supply Chain Management
- Tissue Engineering and Regenerative Medicine
- Genomics and Chromatin Dynamics
- Viral gastroenteritis research and epidemiology
- Optical Imaging and Spectroscopy Techniques
- Advanced Chemical Sensor Technologies
- Viral Infections and Immunology Research
- Lignin and Wood Chemistry
- Insect and Arachnid Ecology and Behavior
- Cloud Computing and Resource Management
- Pain Mechanisms and Treatments
- Housing Market and Economics
National Institute of Dental and Craniofacial Research
2006-2025
Massachusetts Institute of Technology
2025
Hanoi University of Science and Technology
2023-2024
Industrial University of Ho Chi Minh City
2023
Moscow Institute of Thermal Technology
2023
Vinmec International Hospital
2021-2022
Ho Chi Minh City University of Transport
2022
National Institutes of Health
2007-2021
National University of Singapore
2019-2021
Columbia University Irving Medical Center
2020-2021
There is significant interest in the development and application of deep neural networks (DNNs) to neuroimaging data. A growing literature suggests that DNNs outperform their classical counterparts a variety applications, yet there are few direct comparisons relative utility. Here, we compared performance three DNN architectures machine learning algorithm (kernel regression) predicting individual phenotypes from whole-brain resting-state functional connectivity (RSFC) patterns. One was...
Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to skin, muscles, bones, and viscera detect touch temperature as well mediate proprioception many types of interoception. In addition, somatosensory system conveys clinically relevant noxious sensations pain itch. Here, we used single nuclear transcriptomics characterize transcriptomic classes human DRG that these diverse stimuli. Notably, multiple have features resemble their mouse counterparts although...
The trigeminal ganglion contains somatosensory neurons that detect a range of thermal, mechanical and chemical cues innervate unique sensory compartments in the head neck including eyes, nose, mouth, meninges vibrissae. We used single-cell sequencing situ hybridization to examine cellular diversity mice, defining thirteen clusters neurons. show are well conserved dorsal root ganglia suggesting they represent distinct functional classes not specialization associated with their targets....
This study seeks to investigate the relationship between quality management practices and sustainability performance as well moderating effects from implementation timeline, type of industry, firm size on this relationship. Data were collected enterprises in Vietnam July 2016 March 2017. Based a sample 144 valid responses, empirical results indicate that have mixed impacts economic environmental performance, while show positive impact social performance. The found four significantly...
In mice, spared nerve injury replicates symptoms of human neuropathic pain and induces upregulation many genes in somatosensory neurons. Here we used single cell transcriptomics to probe the effects partial infraorbital transection trigeminal at cellular level. Uninjured neurons were unaffected by major branches, segregating into different classes. marked contrast, axotomy rapidly transformed damaged just two new closely-related classes where almost all original identity was lost....
Despite the potential importance of genital mechanosensation for sexual reproduction, little is known about how perineal touch influences mating. We explored affords exquisite awareness genitals and controls reproduction in mice humans. Using genetic strategies vivo functional imaging, we demonstrated that mechanosensitive ion channel PIEZO2 (piezo-type component 2) necessary behavioral sensitivity to touch. function needed triggering a touch-evoked erection reflex successful mating both...
Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms disease models touch pain. We discover that, by overexpressing NGN2 BRN3A, human pluripotent stem cells can be transcriptionally programmed to differentiate into surprisingly uniform culture cold- mechano-sensing neurons. Although such neuronal subtype is not found mice, we identify molecular evidence its existence ganglia. Combining BRN3A programming with...
Abstract Background Although umbilical cord blood (UCB) is identified as a source of mesenchymal stem cells (MSCs) with various advantages, the success in cell isolation volatile. Therefore, it necessary to optimize methods blood-derived MSC (UCB-MSC) and culture. In this study, we evaluated efficiency UCB-MSC expansion using different commercially available serum- xeno-free media investigated capacity autologous serum plasma supplement support proliferation. Additionally, defined presence...
Axon guidance is regulated by intrinsic factors and extrinsic cues provided other neurons, glia target muscles. Dawdle (Daw), a divergent TGF-β superfamily ligand expressed in mesoderm, required for embryonic motoneuron pathfinding Drosophila. In dawmutants, ISNb SNa axons fail to extend completely are unable innervate their targets. We find that Daw initiates an activin signaling pathway via the receptors Punt Baboon (Babo) signal-transducer Smad2. Furthermore, mutations these components...
Rotavirus A (RVA) strains, a leading cause of severe gastroenteritis in children worldwide, commonly possess the Wa or DS-1 genotype constellations. During hospital-based study conducted Hanoi, Vietnam, 2012-2013 rotavirus season, G1P[8] strains with virtually identical short RNA migration pattern were detected 20 (14%) 141 rotavirus-positive samples. Two representatives these shown by whole-genome sequencing to be double-gene reassortants possessing constellation...
The outbreak of the Covid-19 epidemic has caused some disruption to real estate market in Vietnam. To survive pandemic, businesses have rushed find alternative solutions, proactively approach support packages, and change business strategies. Moreover, is critical linked many manufacturing industries development attracting resources, creating significant fixed assets for economy, contributing country's industrialization modernization. Thus, paper's main objective study various factors...
Heterozygous human NKX2-5 homeodomain (DNA-binding domain) missense mutations are highly penetrant for varied congenital heart defects, including progressive atrioventricular (AV) block requiring pacemaker implantation. We recently replicated this genetic defect in a murine knockin model, which we demonstrated penetrant, pleiotropic cardiac anomalies. In study, examined postnatal AV conduction the mice.A model (Arg52Gly, Nkx2-5(+/R52G)) 129/Sv background was analyzed by histopathology,...