A5103212490- T-cell and B-cell Immunology
- Bone Metabolism and Diseases
- Genetic and phenotypic traits in livestock
- Reproductive Physiology in Livestock
- Diverse Aspects of Tourism Research
- Immunotherapy and Immune Responses
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Bone health and treatments
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Animal Genetics and Reproduction
- Veterinary Oncology Research
- Subterranean biodiversity and taxonomy
- interferon and immune responses
- Chromosomal and Genetic Variations
- Virus-based gene therapy research
- Genetic Syndromes and Imprinting
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- HVDC Systems and Fault Protection
- Monoclonal and Polyclonal Antibodies Research
- Bone and Dental Protein Studies
- Smart Grid Energy Management
Swedish University of Agricultural Sciences
2016-2025
Karolinska Institutet
2009-2025
Södertörn University
2016-2023
Oslo University Hospital
2023
Swedish Museum of Natural History
2001-2022
Gothenburg Natural History Museum
2004-2022
Canadian Standards Association
2020-2021
Karolinska University Hospital
2002-2018
Science for Life Laboratory
2013-2018
Swedish Species Information Centre
2010-2018
Ovariectomy in young, growing rodents results decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both these effects are reversed by treatment with estrogen. The aim present study was to determine physiological role estrogen receptor-β (ERβ) on structure content (BMC). BMC adult (11 weeks old), but not prepubertal (4 female ERβ–/– mice compared wild-type (WT) mice. This increase females due BMD, an cross-sectional area associated a growth. Male...
Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly aromatization androgens into estrogen and, thereafter, (ERs). The relative importance ER subtypes in regulation was studied ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO DERKO, but not BERKO, demonstrated decreased longitudinal as well radial skeletal growth associated with serum levels insulin-like factor I. Therefore, ERα, ERβ, mediates...
The tartrate-resistant acid phosphatase (TRAP) of skeletal osteoclasts was found to partially dephosphorylate the bone matrix phosphoproteins osteopontin (OPN) and sialoprotein (BSP). TRAP also dephosphorylated metabolically [32P]PO4-labeled OPN as well BSP, whereas comparable amounts either alkaline or prostatic phosphatase, at their respective pH optima, were ineffective, indicating a certain preference for these phosphoprotein substrates. It has previously (Flores, M., Norgard, Heinegard,...
In vivo models of uremia are important tools to study numerous aspects acute and chronic kidney disease. Mouse pivotal because most genetically engineered animal mice, which allow dissecting the impact selected target genes in renal failure. Adenine-based protocols induce failure available rats, but have not been adapted mice due their reluctance consume adenine. current paper we developed a novel method for induction through dietary delivery adenine mixed casein-based diet.After an phase,...
The genes of the polymorphic HLA-DR molecules are located within human major histocompatibility complex.We have studied an HLA homozygous individual typed to be DR4, Dw4, and DRw53.Fourteen cosmid phage clones from genomic libraries were isolated grouped into three clusters comprising a total 165 kilobases.These contain four DRj3 genes.Nucleotide sequence determination showed that two encode j3 chains carry DR4 DRw53 specificities, respectively, while other presumably pseudogenes.Comparisons...
This study identifies a previously uncharacterized protein, encoded by domesticated DNA transposon, called ZBED6 that regulates the expression of insulin-like growth factor 2 (IGF2) gene, and possibly numerous others, in all placental mammals including human.
We have determined the complete nucleotide sequence of a human class II histocompatibility antigen DC beta gene. The gene spans more than 7 kilobases and contains five exons corresponding to different domains polypeptide. exon-intron organization is thus analogous that alpha-chain genes, I heavy chain constant parts immunoglobulin emphasizing further evolutionary relationship among these molecules. mature polypeptide deduced from shows 93% 88% homology, respectively, sequences derived two...
Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, reduced abundance is considered pathogenic factor in renal secondary hyperparathyroidism. To dissect the role parathyroid gland resident health disease, we generated mice with parathyroid-specific deletion (PTH-KL−/−). PTH-KL−/− had normal gross phenotype survival; serum calcium; unaltered expression gene tissue; preserved response sensitivity to acute changes calcium. Their...
Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion pro-opiomelanocortin (POMC) with an allele frequency 12%. The disrupts the β-MSH and β-endorphin coding sequences is associated body weight (per effect 0.33 SD), adiposity, greater food motivation. Among other dog breeds, was only found closely related flat-coat (FCR), where it similarly mutation significantly more common retrievers selected to become assistance than pets. In conclusion, POMC...
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification intramuscular fat (IMF) remain to be elucidated. Using two independent intercrosses between Western commercial breeds Korean native pigs (KNPs) a joint linkage-linkage disequilibrium analysis, we identified 488.1-kb region on porcine chromosome 12 that affects both reddish color (a*) IMF. In this critical region, only MYH3 gene,...
Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all recombinant viruses, with receptor-binding domain PERV-A combining PERV-C-related sequences.
Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both receptors, were given subcutaneously (2.3 micro g/mouse per day) effects on different estrogen-responsive parameters, including skeletal studied. We found that increased cortical bone dimensions in wild-type (WT) double ER knockout (DERKO) mice. DNA microarray analysis was...
In recent CIGRÉ literature, an index was proposed to assess the degree of voltage interaction among HVDC converters in a multi-infeed configuration. However, is derived from empirical information, its usage somewhat arbitrary or "rule-of-thumb" basis. this paper, power-flow model used as mathematical framework derive analytic equivalent index, facilitate rigorous analysis voltage/power interactions systems. Moreover, with other allied new indices here and past works, it shown that taxanomy...
Gliomas are the most common form of malignant primary brain tumors in humans and second dogs, occurring with similar frequencies both species. Dogs valuable spontaneous models human complex diseases including cancers may provide insight into disease susceptibility oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog Boston Terrier have an elevated risk developing glioma, but others, Pug Pekingese, not at higher risk. To identify glioma-associated genetic factors, across-breed...
Background and Aim: Global warming challenges cattle productivity welfare since it affects heat stress scarce feed. The heat-shock protein 70 (HSP70) gene is essential in cytoprotection against stressors, protecting cells from dysregulated expression apoptosis. This study aimed to identify significant genetic markers of the HSP70.1 that can be leveraged genetically enhance thermotolerance production Bali further. Materials Methods: Animals were sampled three different rearing systems. In...
Purple acid phosphatases (PAPs) are binuclear metallohydrolases also referred to as tartrate-resistant (TRAPs) or type 5 phosphatases. The cDNA sequences of TRAP/PAP enzymes from different species and organs indicate that these translated monomeric polypeptides approx. 35 kDa, contrasting with the predominantly two-subunit structure observed in purified enzyme preparations. In present study we have compared certain structural enzyme-kinetic properties recombinant rat PAP (monomeric) those...
Endogenous nitric oxide (NO) is thought to regulate many biological functions, including pulmonary circulation and bronchomotion, it has been found in exhaled air. Our aim was study the excretion of NO different parts respiratory system. Exhaled concentrations were measured by chemiluminescence chronic tracheostomy outpatients (group 1), patients admitted for minor abdominal surgery 2), with acute failure (ARF) during mechanical ventilation 3). In awake volunteers 4), 0.57 L/min gas...
The human major histocompatibility complex, HLA, contains the genes of several class I1 molecules.We present here molecular maps DQ and DX subregions analyze sequences polymorphic DQa DQJ~ as well DXa DXD genes.The DQJ9 are oriented in opposite directions, approximately 12 kilobases apart.The DX/3 similarly about 8 kilobases.The exon-intron organizations analogous to those other genes.Comparison gene sequence three cDNA clones shows that amino acid replacements predominantly located between...