A5072152965- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Agriculture, Soil, Plant Science
- Animal Genetics and Reproduction
- Food Quality and Safety Studies
- Genetic Syndromes and Imprinting
- melanin and skin pigmentation
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Nutrition, Health and Food Behavior
- Identification and Quantification in Food
- Xenotransplantation and immune response
- Adipose Tissue and Metabolism
- Genomics and Phylogenetic Studies
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Biochemical effects in animals
- CRISPR and Genetic Engineering
- Genetic diversity and population structure
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Plant Breeding
National Institute of Animal Science
2016-2025
Rural Development Administration
2013-2025
GS Caltex (South Korea)
2024
Korea Advanced Institute of Science and Technology
2021
Gyeongsang National University
2009
Swedish University of Agricultural Sciences
2008
Sejong General Hospital
1999
Muscle development and lipid accumulation in muscle critically affect meat quality of livestock. However, the genetic factors underlying myofiber-type specification intramuscular fat (IMF) remain to be elucidated. Using two independent intercrosses between Western commercial breeds Korean native pigs (KNPs) a joint linkage-linkage disequilibrium analysis, we identified 488.1-kb region on porcine chromosome 12 that affects both reddish color (a*) IMF. In this critical region, only MYH3 gene,...
Genomic imprinting is an epigenetic process that results in parent-of-origin effects on mammalian development and growth. Research genomic domesticated animals has lagged due to a primary focus orthologs of mouse human imprinted genes. This emphasis limited the discovery genes specific livestock. To identify pigs, we generated parthenogenetic porcine embryos alongside biparental normal embryos, then performed whole-genome bisulfite sequencing RNA these samples. In our analyses, discovered...
Abstract Background Meat quality traits are important in pig breeding programs, but they difficult to include a traditional selection program. Marker assisted (MAS) of meat is therefore interest programs and Quantitative Trait Locus (QTL) analysis the key identifying markers that can be used MAS. In this study, Landrace Hampshire intercross backcross families were investigate traits. pigs commonly as sire line commercial breeding. This first time pedigree including has been for QTL Results...
We conducted a genome-wide linkage analysis to identify quantitative trait loci (QTL) that influence meat quality-related traits in large F2 intercross between Landrace and Korean native pigs. Thirteen of the m. longissimus lumborum et thoracis were measured more than 830 progeny. All these animals genotyped with 173 microsatellite markers located throughout pig genome, GridQTL program based on least squares regression model was used perform QTL analysis. identified 23 significant eight...
Abstract Background Many studies have been performed to identify various genomic loci and genes associated with the meat quality in pigs. However, full genetic architecture of trait still remains unclear part because lack accurate identification related structural variations (SVs) which resulted from shortage target breeds, limitations sequencing data, incompleteness genome assemblies. The recent generation a new pig breed superior quality, called Nanchukmacdon, its chromosome-level assembly...
Jeju native pig (JNP) is an indigenous breed originating from Korea, characterized by short black hair, small stature, and superior meat quality compared with commercial breeds. This study investigated transcriptome differences in the Longissimus dorsi muscles of Landrace JNP pigs. Phenotypic analysis traits was performed on each breed, revealing significant cooking loss, crude fat, moisture, lightness, redness, shear force, pH, hardness, gumminess, chewiness (p < 0.05). exhibited...
Abstract A subset of mammalian genes undergoes genomic imprinting, and parent-of-origin-dependent expression imprinted is required for normal development. Although around 40 have been documented in pigs, more detailed investigations into domains are needed to uncover the imprinting uncharacterized porcine long non-coding RNAs (lncRNAs). Our study objectives were investigate status orthologous MIMT1 lncRNA transcripts which remains unidentified, explore their allelic multiple tissues...
Myosin heavy chain (MyHC) isoforms consist of Myh7, Myh2, Myh1, and Myh4, which are expressed in skeletal muscle tissues during postnatal development. These genes influence the contraction–relaxation activity muscles involved determining composition such as proportion fast-to-slow and/or slow-to-fast fiber types. Among them, Myh1 is associated with contraction both transition. However, transition mechanism not well understood. For this study, we first produced porcine transgenic (TG) mice to...
Meningocele and meningoencephalocele of the skull are congenital deformities. Various species, such as pigs, dogs, cats, susceptible to meningocele incidence is higher in large white landrace pigs. In this study, swelling was observed fontanel areas median planes cap two female piglets same litter. Gross clinical examination, neurological computed tomography (CT), magnetic resonance imaging (MRI) were conducted on symptomatic piglets. The gross examinations revealed no specific findings,...
Abstract Background Aside from single nucleotide polymorphisms, copy number variations (CNVs) are the most important factors in susceptibility to genetic disorders because they affect expression levels of genes. In previous studies, pyrosequencing, mini-sequencing, real-time PCR, invader assays and other techniques have been used detect CNVs. However, higher a genome, more difficult it is resolve copies, so accurate method for measuring CNVs assigning genotype needed. Results PCR followed by...
돼지 원산지 추적 및 브랜드육 식별을 위한 MS marker set를 확립하기 위해 EU의 EID+DNA DNA Tracing 연구 project, 국제동물유전학회 Roslin 연구소 등에서 제안한 돼지의 다형성 분석에 사용되는 중 17종을 선발하여 다형성지수, F-통계량, 동일개체 출현확률 친자감별확률 등을 MSA, CERVUS, FSTAT, GENEPOP API-CALC 프로그램 연계적으로 활용하여 추정하였다. 다형성지수 추정치를 1차 선발요인으로 하고, 각 marker의 PCR 결과물의 크기 분석 비용의 경제성을 추가로 감안하여 최종 13종의 (SW936, SW951, SW787, S00090, S0026, SW122, SW857, S0005, SW72, S0155, S0225, SW24 and SW632)와 성감별을 2개의 성감별 primer로 조합된 하나의 Multiplexing 시스템을 확립하였다. 이를 이용해 사육환경을 무작위 교배집단(PI), 반형매 교배집단...
소의 Extension (E), Agouti (A) 유전자형과 모색유전양상의 연관관계를 이해하기 위해, 한우와 제주흑우(JBC), 이들 사이에서 생산된 교배후손에서 melanocortin-1 receptor (MC1R)과 agouti signaling protein (ASIP)의 유전자형을 분석하였다. 흑모색의 JBC에서는 세 가지 MC1R 대립인자들(<TEX>$E^D$</TEX>, <TEX>$E^+$</TEX>, e)이 모두 발견되었다. JBC 집단은 한우에서 우점적으로 나타나는 열성동형접합자(e/e)가 발견되지 않았다. 반면, <TEX>$E^+$</TEX>/e 한우는 흑모색이 아닌 갈색이나 적색의 모색을 나타내었다. ASIP 유전자에서, 한우에서는 L1-BT 전위인자의 삽입/결실에 의해 유전자형(A/A, A/<TEX>$A^{Br}$</TEX>, <TEX>$A^{Br}/A^{Br}$</TEX>)이 관찰되었다. 집단에서는 <TEX>$A^{Br}$</TEX> 대립인자가 드물게...
Pig as a food source serves daily dietary demand to wide population around the world. Preference of meat depends on various factors with muscle play central role. In this regards, selective breeding abled us develop "Nanchukmacdon" pig breeds an enhanced variety and high fertility rate. To identify genomic regions under selection we performed whole-genome resequencing, transcriptome, bisulfite sequencing from Nanchukmacdon muscles samples used published data for three other such Landrace,...
The highly polymorphic porcine major histocompatibility complex (MHC), or the swine leukocyte antigens (SLA), has been repeatedly associated with variations in immune response to pathogens and vaccines as well production traits. SLA are also important targets for immunological recognition of foreign tissue grafts. We recently established a resource population Korean native pigs models human transplantation xenotransplantation research. In this study, 115 animals derived from three...
Clinical-chemical traits are essential when examining the health status of individuals. The aim this study was to identify quantitative trait loci (QTL) and associated positional candidate genes affecting clinical-chemical in a reciprocal F(2) intercross between Landrace Korean native pigs. Following an overnight fast, 25 serum phenotypes related (e.g., hepatic function parameters, renal electrolyte, lipids) were measured >970 progeny. All experimental samples subjected genotyping analysis...