A5100602529- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Pleural and Pulmonary Diseases
- PI3K/AKT/mTOR signaling in cancer
- Amyotrophic Lateral Sclerosis Research
- Pharmacological Receptor Mechanisms and Effects
- Reproductive System and Pregnancy
- Synthesis and Reactions of Organic Compounds
- interferon and immune responses
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- RNA Research and Splicing
- Polyamine Metabolism and Applications
- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Nuclear Structure and Function
- Endometriosis Research and Treatment
- Nitric Oxide and Endothelin Effects
- Cancer Mechanisms and Therapy
- Alzheimer's disease research and treatments
- Signaling Pathways in Disease
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
People's Hospital of Xinjiang Uygur Autonomous Region
2025
China Pharmaceutical University
2001-2024
Chengdu University of Traditional Chinese Medicine
2024
China-Japan Friendship Hospital
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Emory University
2018
Soochow University
2011
Pennsylvania State University
2011
Central South University
2005-2010
Xiangya Hospital Central South University
2010
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark the amyotrophic lateral sclerosis frontotemporal dementia disease spectrum (ALS/FTD). However, composition aggregates their contribution to process remain unknown. Here we used proximity-dependent biotin identification (BioID) interrogate interactome detergent-insoluble TDP-43 found them enriched for components nuclear pore complex nucleocytoplasmic transport...
Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through apoptosis autophagy were modulated in cells subjected inhibition by MK-2206, first allosteric small molecule inhibitor enter clinical development. human glioma cells, MK-2206 or siRNA-mediated attenuation strongly activated whereas silencing eukaryotic elongation factor-2 (eEF-2) kinase, a...
Depressive disorder is one of the mental illnesses with highest global disability rates. Homocysteine (Hcy), a non-essential sulfur-containing amino acid, serves as significant risk factor in development and progression various diseases. Current research has revealed close association between Hcy depressive disorder. This review focuses on elucidating mechanisms pathogenesis explores its potential both biomarker therapeutic target.
Abstract DNA damage is a critical component of neuronal death underlying neurodegenerative diseases and injury. Neuronal evoked by characterized inappropriate activation multiple cell cycle components. However, the mechanism regulating this not fully understood. We demonstrated previously that division (Cdc) 25A phosphatase mediates cyclin‐dependent kinases damaging agent camptothecin. also showed Cdc25A blocked constitutive checkpoint kinase 1 activity under basal conditions in neurons....
Objective To investigate the expression of 5-lipoxygenase (5-LOX) in endometriosis and analyze relationship 5-LOX angionesis endometriosis. Methods Immunochemical method was used to determine 5-LOX, VEGF, value MVD ectopic endometrium (ec-topic group) eutopic (eutopic 32 patients with EMs ( control 25 without EMs. Result The expressions VECF groups were 0. 43 ± 0.09,0. 39 ±0.07 0.40 0.09, respectively, which higher than that group group. VEGF 35 08, 0.30 06 33 P <0.05). In group, stage...