A5012121442- Health disparities and outcomes
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Technology Use by Older Adults
- Aging and Gerontology Research
- Chronic Disease Management Strategies
- Hearing, Cochlea, Tinnitus, Genetics
- Prion Diseases and Protein Misfolding
- Healthcare Systems and Public Health
- Impact of Technology on Adolescents
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Anesthesia and Neurotoxicity Research
- Dementia and Cognitive Impairment Research
- Retirement, Disability, and Employment
- Pharmacological Effects and Toxicity Studies
- COVID-19 and Mental Health
- Geriatric Care and Nursing Homes
- RNA Research and Splicing
- Social and Behavioral Studies
- Health, psychology, and well-being
- Neurogenetic and Muscular Disorders Research
- Noise Effects and Management
Johns Hopkins University
2022-2025
Johns Hopkins Medicine
2022-2025
University of Michigan
2024
Emory University
2016-2018
University of Massachusetts Chan Medical School
2016
University of Pennsylvania
2012
Institute on Aging
2012
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a common histopathological hallmark the amyotrophic lateral sclerosis frontotemporal dementia disease spectrum (ALS/FTD). However, composition aggregates their contribution to process remain unknown. Here we used proximity-dependent biotin identification (BioID) interrogate interactome detergent-insoluble TDP-43 found them enriched for components nuclear pore complex nucleocytoplasmic transport...
Research Article30 November 2017Open Access Transparent process A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain Mfon E Umoh Department of Neurology, Emory University School Medicine, Atlanta, GA, USA Center for Neurodegenerative Diseases, Search more papers by this author Eric B Dammer Biochemistry, Jingting Dai Duc M Duong James J Lah Allan I Levey Marla Gearing Pathology Laboratory Jonathan D Glass...
We investigated whether the C9orf72 expansion mutation in patients with amyotrophic lateral sclerosis (ALS) is associated unique demographic and clinical features.Between 2001 2015, approximately half of all attending Emory ALS Clinic agreed to donate DNA for research. This research cohort 781 was screened expansion, data were compared between those without mutation. For carriers a family history ALS, we sought further dementia other non-ALS neurodegenerative diseases first-degree...
Abstract Background Social isolation is a key public health concern and has been associated with numerous negative consequences. Technology increasingly thought of as solution to address social isolation. This study examines the longitudinal association between access use technology in older adults 65 older, living United States. Methods observational cohort included community‐dwelling ( N = 6704) who participated National Health Aging Trends Study. Regression analyses were conducted using...
Abstract Background Social isolation is a well-known risk factor for poor health outcomes, including incident dementia, yet its associations with outcomes among persons living dementia are understudied. We examined the association between social and hospitalization nationally representative sample of older adults without dementia. Methods This observational cohort study included 5 533 community-dwelling Medicare beneficiaries from 2015 2016 National Health Aging Trends Study (NHATS). Using...
Purpose: Experiencing difficulty with activities of daily living (ADLs) and instrumental ADLs (IADLs) and/or the consequences unmet ADL/IADL-related needs is associated adverse health-related outcomes. The association hearing loss (HL) experiencing not well understood. We investigated associations HL ADL/IADL difficulties in older adults. Method: cross-sectional between audiometric HL, number ADL IADL difficulties, among adults aged 65 years National Health Aging Trends Study. Results: In...
The therapeutic landscape of Alzheimer's disease (AD) is rapidly changing. Disease-modifying medications for AD that target amyloid-beta (Aß) deposits in the brain have been approved by Food and Drug Administration (FDA) recent years. However, there remain many questions about which patients are most appropriate these medications. One group particular with unique considerations includes older adults a prior history seizures. seizures represent an important, bidirectional relationship. This...
The authors declare no conflicts of interest.
Abstract A growing body of literature demonstrates a strong association between social isolation and the risk incident dementia. However, research examining objective among persons living with dementia (PLWD) has been limited. The behavioral psychological symptoms may reduce connection. Research that uses population-based, national surveys to examine this issue PLWD must consider missing data proxy interview responses. We report new evidence on prevalence sample community-dwelling offer...
Abstract Social isolation is linked to adverse health outcomes; 25% of older adults in the United States are socially isolated. However, episodic social may carry different implications for outcomes compared chronic isolation. Many studies examine at a single point rather than considering it as circumstance that intermittent or persistent. This study examined dynamics using nationally representative cohort data from 11 rounds National Health and Aging Trends Study (N=6,913) describe...
The cytoplasmic mislocalization and aggregation of the RNA-binding protein TAR DNA binding protein-43 (TDP-43) is a histopathological hallmark amyotrophic lateral sclerosis frontotemporal dementia disease spectrum (ALS-FTD), other neurodegenerative disorders. A key feature TDP-43 pathology formation detergent-insoluble aggregates hyper-phosphorylation, ubiquitination cleaved C-terminal fragment (CTF). Although inclusions may sequester interacting proteins impair RNA homeostasis, nature...