A5011445343- Graphene research and applications
- X-ray Diffraction in Crystallography
- Single-cell and spatial transcriptomics
- Chromosomal and Genetic Variations
- Crystallization and Solubility Studies
- Carbon Nanotubes in Composites
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Metal-Organic Frameworks: Synthesis and Applications
- Graphene and Nanomaterials Applications
- Plant Reproductive Biology
- Gene expression and cancer classification
- Cancer Genomics and Diagnostics
- Boron and Carbon Nanomaterials Research
- Genetic Mapping and Diversity in Plants and Animals
- Wireless Power Transfer Systems
- Genomics and Phylogenetic Studies
- Pancreatitis Pathology and Treatment
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Genomic variations and chromosomal abnormalities
- Pancreatic and Hepatic Oncology Research
- Circadian rhythm and melatonin
- Molecular Biology Techniques and Applications
Dalian Medical University
2025
University of Cambridge
2025
Beihang University
2023-2025
Inner Mongolia Agricultural University
2025
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2025
Harvard University
2022-2025
Hubei University of Medicine
2019-2024
National Jewish Health
2024
Beijing Forestry University
2022-2024
Taihe Hospital
2020-2024
The advent of single-cell RNA sequencing (scRNA-seq) technologies has revolutionized transcriptomic studies. However, large-scale integrative analysis scRNA-seq data remains a challenge largely due to unwanted batch effects and the limited transferabilty, interpretability, scalability existing computational methods. We present Embedded Topic Model (scETM). Our key contribution is utilization transferable neural-network-based encoder while having an interpretable linear decoder via matrix...
The formation of diploid gametes through chromosome doubling is a major mechanism polyploidization, diversification, and speciation in plants. Unfavorable climate conditions can induce or stimulate the production during meiosis. Here, we demonstrated that heat shock stress (38°C for 3 6 h) induced 2n pollen formation, generated 42 triploids derived from shock-induced Populus canescens. Meiotic analysis treated mother cells revealed originated complete loss meiosis II (MII). Among triploids,...
Macrophages are required for healthy repair of the lungs following injury, but they also implicated in driving dysregulated with fibrosis. How these two distinct outcomes lung injury mediated by different macrophage subsets is unknown. To assess this, single-cell RNA sequencing was performed on macrophages isolated from mice treated lipopolysaccharide or bleomycin. were categorized based anatomic location (airspace versus interstitium), developmental origin (embryonic recruited...
High-frequency inductive power transfer (IPT) has garnered significant attention in recent years due to its long transmission distance and high efficiency. The inductance values L quality factors Q of the transmitting receiving coils greatly influence system's operation. Traditional methods involved impedance analyzers or network for measurement, which required bulky costly equipment. Moreover, disassembling it re-measurement is impractical once product packaged. Alternatively, simulation...
This study aimed to develop an effective tail typing detection technology based on the TaqMan probe for genotyping different sheep types. A total of 122 Hulun Buir short-tailed and 50 Hu were enrolled in compare their morphologies, lengths, widths. Through Sanger sequencing loci 333 334 second exon T gene, distinct genotypes various types identified. In addition, was employed genotype two SNP gene sheep. It observed that at exhibited genotypes, CT/CT CT/GG, but this feature not detected The...
Gastric cancer (GC) remains one of the leading causes cancer-related mortality worldwide. Accurate prognostic assessment, which is essential for enhancing overall survival (OS), currently depends on pathologic and clinical staging. This underscores urgent need reliable real-time biomarkers. The triglyceride-glucose (TyG) index, a readily available marker insulin resistance, has recently emerged as potential tool in GC. Numerous studies have consistently shown significant association between...
This paper reviews the recent advancements of III–V semiconductor wires as optical switches in solid-state lasers, while addressing impact factors such strain and diameter on their electronic structure thermal conductivity.
This study designed three sgRNAs (sgRNA139, sgRNA128, and sgRNA109) targeting the prolactin gene receptor (PRLR) in fetal cattle, utilized Cas9 to cleave endogenous DNA, screened stable cell lines for somatic nuclear transfer experiments investigate impact of different editing sites on embryonic development. The results showed that sgRNA139 had highest cleavage efficiency (Fcut = 0.65, Indels 42.19%), while sgRNA109 lowest 0.45, 35.31%). No significant differences were observed growth status...
Tb<sup>3+</sup>-Doped Eu<sup>3+</sup> MOFs exhibit efficient white light emission and Tb-MOF displays a highly sensitive response toward Fe<sup>3+</sup> ions.
The aim was to investigate the independent prognostic factors and construct a risk prediction model facilitate formulation of oral squamous cell carcinoma (OSCC) clinical treatment plan. We constructed using univariate COX, Lasso, multivariate COX regression analysis conducted statistical analysis. In this study, 195 randomly obtained sample sets were defined as training set, while 390 samples constituted validation set for testing. A based on nine survival-associated metabolic genes, among...
Improvements in single-cell whole-genome sequencing (scWGS) assays have enabled detailed characterization of somatic copy number alterations (CNAs) at the level. Yet, current computational methods are mostly designed for detecting chromosome-scale changes cancer samples with low coverage. Here, we introduce HiScanner (High-resolution Single-Cell Allelic Number callER), which combines read depth, B-allele frequency, and haplotype phasing to identify CNAs high resolution. In simulated data,...
A new structure of 2D films woven with single-walled CNTs was studied by molecular simulation. The presents obvious anisotropy high impacting strength and percentage absorbed energy. This work broadens the applications CNT-based nanomaterials.
Graphene, as the representative of two-dimensional materials, has varous novel physical properties and potential applications. The intrinsic zero band gap graphene limits its application in semiconductor devices, thus search for new semiconducting alternative materials become a current research hotspot. Phosphorene is monolayer black phosphorus puckered honeycomb structure. Its advanced properties, such adjustable direct gap, high carrier mobility in-plane anisotropy so on, have recently...
The plant hormone gibberellin (GA) regulates many physiological processes, such as cell differentiation, elongation, seed germination, and the response to abiotic stress. Here, we found that injecting male flower buds with exogenous gibberellic acid (GA3) caused defects in meiotic cytokinesis by interfering radial microtubule array formation resulting restitution 2n pollen production Populus. A protocol for inducing Populus GA3 was established investigating effects of dominant stage,...