A5014975219- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Gastric Cancer Management and Outcomes
- Digestive system and related health
- Gastrointestinal disorders and treatments
- Infant Health and Development
- Ion channel regulation and function
- Pediatric health and respiratory diseases
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Nanoparticles: synthesis and applications
- Erythrocyte Function and Pathophysiology
- Intestinal Malrotation and Obstruction Disorders
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Veterinary medicine and infectious diseases
- Urinary Tract Infections Management
- Congenital gastrointestinal and neural anomalies
- Vasculitis and related conditions
- Congenital Diaphragmatic Hernia Studies
Children's Hospital of Zhejiang University
2016-2025
Zhejiang University
2012-2025
National Clinical Research
2020-2024
Ten Chen Hospital
2022
University of Louisville
2013-2020
Minzu University of China
2014
Lishui Central Hospital
2013
National Natural Science Foundation of China
2013
Ministry of Education of the People's Republic of China
2012
University of Fukui
2000-2004
Externally controlling the excitation of a neuronal subset through ion channels activation can modulate firing pattern an entire neural circuit in vivo. As nanovalves cell membrane, be opened by light (optogenetics) or ultrasonic (sonogenetics) means. A thoroughly analyzed force sensor is Escherichia coli mechanosensitive channel large conductance (MscL). Here we expressed MscL rat hippocampal neurons primary culture and showed that it could activated low-pressure ultrasound pulses. The...
Abstract Background The resistance of Helicobacter pylori ( H. ) to antibiotics is increasing worldwide, lowering its efficacy in current eradication therapies. This study evaluated the southeast coastal region China and suggests appropriate alternatives. Materials Methods Seventeen thousand seven hundred thirty one strains were collected from eight areas two provinces 2010 2012. these six was tested using agar dilution method. Results rates clarithromycin, metronidazole, levofloxacin,...
We and other groups have demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused oxidative stress inflammation, which been shown be strongly associated with genotoxic carcinogenic effects. However, few studies reported Nano-Co-induced effects in vivo. Here, we propose Nano-Co may high due their small size surface area, capacity for causing inflammation. gpt delta transgenic mice were used as our vivo study model. They intratracheally instilled 50 μg per mouse of Nano-Co. At day...
We and other groups have demonstrated that exposure to nickel nanoparticles (Nano-Ni) results in severe persistent lung inflammation fibrosis, but the underlying mechanisms remain unclear. Here, we propose miR-21 may play an important role Nano-Ni-induced inflammation, injury, fibrosis. Our dose- time-response studies of C57BL/6J (WT) mice Nano-Ni resulted upregulation miR-21, proinflammatory cytokines, profibrotic mediators. Histologically, caused pulmonary Based on studies, chose a dose 50...
Segmented filamentous bacteria (SFB) are commensal organisms which grow by anchoring a specialized holdfast structure to the intestinal walls of variety animals. Interaction SFB with Peyer's patches in mice promotes post-natal maturation immune system. We previously reported that colonization humans mainly occurs 36 months age, and is difficult be detected afterwards. In this study, we measured level fluids human children. were found via qPCR represent small fraction whole SFB-positive...
Previous studies have demonstrated that exposure to nickel nanoparticles (Nano-Ni) causes oxidative stress and severe, persistent lung inflammation, which are strongly associated with pulmonary toxicity. However, few investigated whether surface modification of Nano-Ni could alter Nano-Ni-induced injury, fibrosis in vivo. Here, we propose alteration physicochemical properties through may change fibrosis. At first, dose–response time-response were performed observe inflammation injury caused...
The effects of heat treatment on the antigenicity and potential allergenicity α-Lactalbumin (α-LA), β-Lactoglobulin (β-LG), α-casein (α-CN), β-casein (β-CN) in milk protein concentrates (MPCs) were investigated at temperatures range 65–100°C for times from 10 to 30 min. α-LA decreased significantly. β-LG was sharply increased throughout treatment, while significantly only 85°C 100°C 25 α-CN β-CN showed fluctuated changes, but all lower than untreated sample. when heated 65°C 70°C Compared...
Stroke is the second leading cause of death worldwide. Patients who have a stroke are susceptible to many gastrointestinal (GI) complications, such as dysphagia, GI bleeding, and fecal incontinence. However, there few studies focusing on tract after stroke. The current study investigate changes intestinal structure function in mice ischemic Ischemic was made disease model mice, which brain ileal tissues were collected for experiments 1st 7th day Intestinal motility inhibited, permeability...
Abstract The increasing rates of antibiotic resistance in Helicobacter pylori ( H. ) are a major concern the decreasing eradication rate. Large-scale and long-period studies on antimicrobial susceptibility children limited. This study aimed to describe temporal changes among southeast China. Gastric biopsies obtained from were cultured for 2015 2020. Susceptibility clarithromycin (CLA), amoxicillin (AML), metronidazole (MTZ), furazolidone (FZD), tetracycline (TET) levofloxacin (LEV) was...
This study aimed to characterize common mutations of antibiotic-resistant gene clarithromycin, metronidazole and levofloxacin in Helicobacter pylori (H. pylori) determine their association with antibiotic resistance H. for providing a strategy eradication therapy infection children.The strains isolated from children was determined by E-test. The mutation domain V 23S rRNA, rdxA frxA genes, gyrA gyrB genes performed PCR-based sequencing DNA fragments.Out the 79 examined, 66 (83.5%) were...
Helicobacter pylori infection is the main cause of chronic gastritis in children. Little known about effect on microbiota and immunity. This study was aimed at characterizing stomach immune-regulatory properties children with colonization. We studied 122 who had undergone gastric endoscopy due to gastrointestinal symptoms, 57 were diagnosed infection. Endoscopic mucosal biopsy samples obtained for DNA RNA extraction. Microbiomes analyzed by 16S rRNA profiling, differentially expressed genes...
Objective: To analyze the clinical features of postnatal cytomegalovirus (pCMV) infection in very preterm infants or low birth weight infants. Methods: This was a case-control study. A total 50 who were hospitalized and diagnosed with pCMV Neonatal Intensive Care Unit Children's Hospital, Zhejiang University School Medicine from January 2019 to June 2024, enrolled as group. Meanwhile, through propensity score matching, each infant group paired without during same period, constituting control...
Bile reflux is one of the primary factors involved in pathogenesis gastric mucosal lesions patients with chronic gastritis; however, little known about exact histological features bile and its contributions to this disease, especially children gastritis (BRG). The aim study was investigate classic changes mucosa BRG.The Bilitec 2000 used for 24 h monitoring 59 upper gastrointestinal symptoms. characteristics were examined scored.Thirteen had a helicobacter pylori infection excluded;...
Helicobacter pylori (HP) culture for diagnosing HP infection is time-consuming and technologically complex. This study evaluated the clinical significance of gastric mucosal gene chip technology in rapid diagnosis detection drug resistance children.Patients (between age 2.5 16.0 years old) manifesting gastrointestinal symptoms were enrolled this study. mucosa sensitivity test performed. A was used to detect presence infection, some single nucleotide polymorphisms genes, or associated...
Objective: To investigate the curative effect and mechanism of hyperbaric oxygen therapy on nonalcoholic fatty liver disease in mice. Methods: Twenty-one 8-week-old male C57BL/6J mice were divided into three groups: control group (normal diet), model (high-fat high-cholesterol diet + therapy), with seven each group. The changes body weight, serum enzymes, blood lipids compared after treatment between groups. Hematoxylin-eosin staining, Oil Red O Sirius red F4/80 immunohistochemical staining...
The intestinal microbiota has emerged as a critical regulator of growth and development in the early postnatal period life. Cesarean section (CS) delivery is one strongest disrupting factors normal colonization process been reported risk factor for disorders later In this study, we dynamically longitudinally evaluated impact CS on initial pattern gut by 16 healthy Chinese infants with fecal samples collected at 9 time points (day 5, day 8, 11, week 2, 4, 6, 7, month 3) during first 3 months...