A5068033367- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Dietary Effects on Health
- Lymphatic Disorders and Treatments
- Ethics in medical practice
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
- Pharmacological Effects and Toxicity Studies
- Childhood Cancer Survivors' Quality of Life
- Inhalation and Respiratory Drug Delivery
- COVID-19 and Mental Health
- FOXO transcription factor regulation
- Medical Malpractice and Liability Issues
- Diabetes and associated disorders
- Diabetes Management and Research
- Intensive Care Unit Cognitive Disorders
- Bariatric Surgery and Outcomes
- Organ and Tissue Transplantation Research
Columbia University
2011-2024
Columbia University Irving Medical Center
2012-2024
Presbyterian Hospital
2014-2020
New York Hospital Queens
2020
NewYork–Presbyterian Hospital
2020
Associação Paulista de Medicina
1993
Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to progenitor-like stage, and partly converting other endocrine cell types.To determine whether similar processes occur human type 2 we surveyed pancreatic islets from 15 diabetic nondiabetic organ donors.We scored dedifferentiation using markers lineage, β-cell-specific transcription factors, newly identified progenitor marker, aldehyde...
Half of the recovered expanded criteria donor (ECD) kidneys are discarded in United States. A new kidney allocation system offers at higher risk discard, Kidney Donor Profile Index (KDPI)>85%, to a wider geographic area promote broader sharing and expedite utilization. Dual transplantation (DKT) based on KDPI is potential option streamline which otherwise would have been discarded. To assess clinical utility we analyzed OPTN/UNOS Registry that included deceased between 2002 2012. The primary...
Biopsies taken at deceased donor kidney procurement continue to be cited as a leading reason for discard; however, the reproducibility and prognostic capability of these biopsies are controversial.We compiled retrospective, single-institution, continuous cohort transplants performed from 2006 2009. Procurement biopsy information-percentage glomerulosclerosis, interstitial fibrosis/tubular atrophy, vascular disease-was obtained national transplant database. Using univariable, multivariable,...
Biopsy findings at the time of procurement deceased donor kidneys remain most common reason cited for kidney discard. To determine value renal allograft histology in predicting outcomes, we evaluated significance histologic findings, read by experienced pathologists, 975 postreperfusion biopsy specimens collected from 2005 to 2009 after living ( n =427) or =548) transplant. We degree glomerulosclerosis, interstitial fibrosis and tubular atrophy, vascular disease; with a score 0 1 (scale,...
Donor safety is of paramount importance in living donor transplantation. Yet, deaths occur. We believe that problems exist our system live transplantation can be summarized a series simple statements: (1) mortality never completely eliminated; (2) Live risk has not been mitigated so it as low possible; (3) After death, systematic reviews are routinely performed to identify correctable causes; (4) The lessons learned from any death adequately communicated other programs and (5) administrative...
Abdominal tumors involving both roots of the celiac and superior mesenteric artery are deemed unresectable by conventional surgical methods. We performed three cases multivisceral ex vivo surgery temporary removal entire abdominal viscera followed vascular reconstruction, tumor resection autotransplantation excised organs. achieved a complete with negative margins in all cases. All patients have survived no recurrence to date at 17-, 27- 38-month follow-up. Postoperative complications...
The factors that influence deceased donor kidney procurement biopsy reliability are not well established. We examined the impact of technique and pathologist training on accuracy.We retrospectively identified all kidney-only transplants at our center from 2006 to 2016 with both reperfusion biopsies performed information available (n = 392). Biopsies were scored using a previously validated system, classifying "suboptimal" histology as presence least 1 following: glomerulosclerosis ≥11%,...
BACKGROUND AND OBJECTIVES Kidney transplantation with minimal or no dialysis exposure provides optimal outcomes for children end-stage kidney disease. We sought to understand disparities in timely access transplant waitlisting. METHODS conducted a retrospective, registry-based cohort study of candidates ages 3 17 added the US waitlist 2015 2019. defined “preemptive waitlisting” as addition before receiving and compared demographics based on preemptive status. used competing risk regression...
Abstract Prolonged warm (WIT) and cold (CIT) ischemia times are often important considerations in the discard of DCD kidneys, but their impact on post‐transplant outcomes post‐KAS era is unclear. We examined association time delayed graft function (DGF) death‐censored failure for kidneys. The 2018 SRTR SAF was utilized to identify kidney transplants occurring from 2015 2018. Relative risk Cox regression were used calculate hazard failure, respectively. identified 4,680 kidneys donors...
Abstract Background Discard rate of Public Health Service Increased Risk (PHS‐IR) organs is high despite the absence worse kidney transplant outcomes. Methods We conducted a retrospective, single‐center study PHS‐IR offers made to transplant‐only potential recipients from 6/2004 5/2015. Overall mortality and outcomes between were stratified by response offers. Cox regression Kaplan‐Meier analyses allograft failure performed. Results A total 2423 offered kidney, with 1502 transplanted, or...
Coronavirus disease 2019 (COVID-19) has become a pandemic since first being described in January 2020. Clinical manifestations non-transplant patients range from asymptomatic infection to severe pneumonia with acute respiratory distress syndrome, multiorgan system failure, and death. Limited reports kidney transplant recipients suggest similar characteristics that population. We report here the case series of COVID-19 occurring pancreas recipients.
Optimal dosing of rabbit antithymocyte globulin (rATG) induction therapy in kidney transplantation is not well defined. The impact from variations dose rounding or single limits has been studied.This retrospective study 242 adult renal transplant recipients receiving rATG and steroid-sparing maintenance evaluates the effect small changes dosing. local protocol calls for four doses 1.5 mg/kg, approximated to nearest 25 mg limited a max 150 mg. Patients were stratified by total received 5 6...
BACKGROUND: Increased pulmonary epithelial permeability evaluated by the rate of clearance from lung to blood radioaerosol solute technetium-99m labelled diethylenetriamine pentaacetate (99mTc-DTPA) has been reported in smokers and workers exposed silica dust. A study was carried out determine whether there are additive effects cigarette smoke exposure dust on rates 99mTc-DTPA ceramic workers. METHODS: Thirty one subjects with silicosis were studied, whom 18 smoked cigarettes 13 non-smokers....
Chylous ascites is a difficult, albeit uncommon complication of laparoscopic live donor nephrectomy (LLDN). Lymphatic leak believed to be result injury the cisterna chyli, regional lymph nodes, or other peri-aortic lymphatics intraoperatively. Recommended management with dietary modifications can in malnutrition and immunodeficiency. We present four patients who developed chylous following LLDN. Approach these evolved over time. Our initial two were successfully treated combination surgical...
Abstract Therapeutic living donor nephrectomy is defined as a that performed therapy for an underlying medical condition. The patient directly benefits from having their kidney removed, but the deemed transplantable. subsequently used allograft individual with advanced renal disease. can be successfully utilized heterogenous cohort of disease processes both treatment and to increase number suitable organs available transplantation. We describe four cases therapeutic were at our institution....
Abstract Introduction Incidental kidneys cysts are typically considered benign, but the presence of is more frequent in individuals with other early markers kidney disease. We studied association donor and recipient outcomes after living transplantation. Methods retrospective identified 860 transplants at our center (1/1/2011–7/31/2022) without missing data. Donor were by review pre‐donation CT scan reports. used linear regression to study between 6‐month single‐kidney estimated glomerular...
Peritoneal dialysis for acute kidney injury is not typically a first-line option mechanically ventilated patients in the intensive care unit. This series investigates technical feasibility and clinical implications of bedside peritoneal catheter placement utilization COVID-19 patients. Patient data was retrospectively collected on patient characteristics, hospital course, fluid balance, ventilatory mechanics associated morbidity mortality qualifying at single center from March to April 2020....
Kidney transplantation is the optimal treatment for children with kidney failure, improving survival and development compared dialysis.1Amaral S. Sayed B.A. Kutner N. Patzer R.E. Preemptive associated benefits among pediatric patients end-stage renal disease.Kidney Int. 2016; 90: 1100-1108Abstract Full Text PDF PubMed Scopus (111) Google Scholar,2Franke D. Thomas L. Steffens R. et al.Patterns of growth after ESRD.Clin J Am Soc Nephrol. 2015; 10: 127-134Crossref (57) Scholar However,...
Medullary sponge kidney (MSK) disease predisposes patients to recurrent nephrolithiasis, which affects one in every 5000 people the United States.We report a rare case of pediatric recipient living donor MSK transplant and discuss considerations when discussing risks benefits accepting allografts for this population.The was admitted due concerns hydronephrosis, urinary tract infection at 1-month post-transplant. The hydronephrosis resolved by surgical removal an encrusted ureteral stent;...
Advances in surgery have made laparoscopic donor nephrectomy (LapNx) a common practice for organ procurement living renal transplantation. While this is minimally invasive procedure, patients experience post-operative pain. This study evaluates analgesic requirements, as morphine equivalents, undergoing LapNx. Methods: Retrospective of 274 adult donors who underwent LapNx from July 2011 to Dec 2013. Post-operative pain management included ketorolac and needed hydromorphone, hydrocodone,...