A5056913094- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Spatial Neglect and Hemispheric Dysfunction
- Mental Health Research Topics
- Nutritional Studies and Diet
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Face Recognition and Perception
- Aging and Gerontology Research
- Cancer-related cognitive impairment studies
- Health disparities and outcomes
- Restless Legs Syndrome Research
- Sleep and related disorders
- Psychological Testing and Assessment
- Behavioral and Psychological Studies
- Visual perception and processing mechanisms
- Organ Donation and Transplantation
- Neuroscience and Music Perception
Brigham and Women's Hospital
2020-2025
Harvard University
2021-2025
Massachusetts General Hospital
2020-2023
Alzheimer’s Disease Neuroimaging Initiative
2022-2023
Brown University
2018-2022
Boston University
2013-2019
Massachusetts Institute of Technology
2011-2015
McGovern Institute for Brain Research
2015
Institute of Cognitive and Brain Sciences
2011
Columbia University
2009
Context: Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD).To our knowledge, this is the first study to examine neuroimaging-based prediction SAD.Objective: To measure brain activation patients with SAD as a biomarker subsequent response cognitive therapy (CBT).Design: Functional magnetic resonance imaging (fMRI) data were collected prior CBT intervention.Changes clinical status regressed on responses and tested for selectivity stimuli.Setting:...
Fluid intelligence is important for successful functioning in the modern world, but much evidence suggests that fluid largely immutable after childhood. Recently, however, researchers have reported gains multiple sessions of adaptive working memory training adults. The current study attempted to replicate and expand those results by administering a broad assessment cognitive abilities personality traits young adults who underwent 20 an dual n-back program comparing their post-training...
Parkinson’s disease (PD) is characterized by motor symptoms, but nonmotor symptoms also significantly impair daily functioning and reduce quality of life. Anxiety prevalent debilitating in PD, remains understudied undertreated. Much affective research PD focuses on depression rather than anxiety, as such, there are no evidence-based treatments for anxiety this population. Cognitive-behavioral therapy (CBT) has shown promise treating may be efficacious anxiety. This exploratory study...
We investigated differences in the intrinsic functional brain organization (functional connectivity) of human reward system between healthy control participants and patients with social anxiety disorder. Functional connectivity was measured resting-state via magnetic resonance imaging (fMRI). 53 disorder 33 underwent a 6-minute fMRI scan. analyzed by calculating whole-brain temporal correlations bilateral nucleus accumbens seed ventromedial prefrontal cortex seed. Patients disorder, relative...
Parkinson's disease (PD) has long been conceptualized as a motor disorder, but nonmotor symptoms also manifest in the and significantly reduce quality of life. Anxiety cognitive dysfunction are prevalent symptoms, even early stages, relation between these remains poorly understood. We examined self-reported anxiety neurocognitive function, indexed by measures executive function (set-shifting phonemic fluency), categorical fluency, attention/working memory. hypothesized that would correlate...
Visuospatial problems are common in Parkinson's disease (PD) and likely stem from dysfunction dopaminergic pathways consequent disruption of cortical functioning. Characterizing the motor symptoms at onset provides a method observing how these influences visuospatial cognition. We examined two types characteristics: Body side (left or right) type initial symptom (tremor other than tremor).31 non-demented patients with PD, 16 left-side (LPD) 15 right-side (RPD), as well 17 healthy control...
Background Promoting brain health depends on sustaining healthy behaviors across the lifespan. Yet, public adoption of lifestyle and knowledge cognitive decline (CD) prevention remains poor. Our multidisciplinary team developed My Healthy Brain (MHB) to promote a (e.g. diet, exercise, alcohol, sleep) build reserve memory compensatory strategies). objective was demonstrate early proof-of-concept for MHB by exploring feasibility, acceptability, improvement in primary outcomes as well secondary...
Parkinson's disease (PD) is associated with deficits in visuospatial attention. It as yet unknown whether these attentional begin at a perceptual level or instead reflect disruptions oculomotor higher-order processes. In the present study, non-demented individuals PD and matched normal control adults (NC) participated two tasks requiring sustained attention, both based on multiple object tracking paradigm. Eye was used to ensure central fixation. Experiment 1 (26 PD, 21 NC), pair of...
Background: Research on Alzheimer disease and related dementias is increasingly focused preventative strategies to target modifiable risk factors (eg, exercise, diet, cognitive stimulation) reduce of decline, though it remains difficult for adults adopt maintain these behaviors their own. Methods/Participants: In this survey study, we examined knowledge about dementia, engagement in healthy lifestyle behaviors, associated barriers/facilitators an prevention registry at-risk, cognitively...
Subjective cognitive decline (SCD) has been associated with elevated amyloid levels and increased risk of future decline, as well modifiable variables, including depression, anxiety, physical inactivity. Participants generally endorse greater earlier concerns than their close family friends (study partners [SPs]), which may reflect subtle changes at the earliest stages disease among participants underlying neurodegenerative processes. However, many individuals subjective are not Alzheimer's...
Abstract Background Research on Alzheimer’s disease (AD) and related dementias is increasingly focused prevention identification of risk factors. In order to effectively disseminate knowledge about dementia risk, there need understand gaps in (Carpenter et al., 2011, Cations 2018). For example, education level, among other factors, may be associated with reduced AD, which could impact engagement early strategies (Ayalon & Arean, 2004). We explored demographic variables a community‐based...