A5080056034- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Cardiac Imaging and Diagnostics
- Lung Cancer Treatments and Mutations
- Chemotherapy-induced cardiotoxicity and mitigation
- Inflammatory Biomarkers in Disease Prognosis
- Head and Neck Cancer Studies
- Effects of Radiation Exposure
- Advances in Oncology and Radiotherapy
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Ultrasound and Hyperthermia Applications
- Cancer Immunotherapy and Biomarkers
- Dysphagia Assessment and Management
- Global Cancer Incidence and Screening
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- PARP inhibition in cancer therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Sarcoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
University of Manchester
2019-2025
Cancer Research UK Manchester Institute
2020-2025
The Christie NHS Foundation Trust
2019-2024
National Health Service
2022-2024
The Christie Hospital
2023
Manchester Academic Health Science Centre
2020
Oslo University Hospital
2017-2020
University of Oslo
2017-2020
Leeds Beckett University
2020
The RTOG 0617 trial presented a worse survival for patients with lung cancer treated in the high-dose (74 Gy) arm. In multivariable models, radiation level and whole-heart volumetric dose parameters were associated survival. this work, we consider heart subregions to explain observed difference between levels.
For patients with lung cancer treated radiation therapy, a dose to the heart is associated excess mortality; however, it often not feasible spare whole heart. Our aim define cardiac substructures and thresholds that optimally reduce early mortality.Fourteen were delineated on 5 template representative anatomies. One thousand one hundred sixty-one non-small cell registered nonrigidly these anatomies, their therapy doses mapped. Mean maximum each substructure extracted, means evaluated as...
Introduction Recent studies suggest that immune-related cells can be recruited for anti-tumor functions as well tumor progression and the interplay between systemic inflammation local immune response may play a major role in development of various cancers including lung cancer. Inflammatory markers, such neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII) used surrogate biomarkers host status. In this work, associations neutrophils,...
Purpose Dysphagia is a common toxicity after head and neck (HN) radiotherapy that negatively affects quality of life. We explored the relationship between dose to normal HN structures dysphagia one year treatment using image-based datamining (IBDM), voxel-based analysis technique. Materials Methods used data from 104 oropharyngeal cancer patients treated with definitive (Chemo)RT. Swallow function was assessed pre-treatment 1 three validated measures: M.D. Anderson Inventory (MDADI),...
For lung cancer patients treated with radiotherapy, radiation dose to the heart has been associated overall survival, volumetric statistics widely presented. However, critical cardiac structures are present on hearts surface, where this approach may be sub-optimal. In work we a methodology for creating surface maps and identify regions excess is in worse survival.A modified cylindrical coordinate system was implemented map patients. Validation performed by mapping chambers 55 patients,...
The European SocieTy for Radiotherapy and Oncology (ESTRO) organized a one-year pilot mentoring programme. At evaluation after one year, both mentors mentees scored the programme with median score of 9 on scale 10. All indicated that they wanted to participate again as mentors.
Lymphopenia during radiotherapy (RT) may have an adverse effect on treatment outcome. The aim of this study is to investigate associations between lymphopenia and RT parameters in patients with advanced lung cancer. Moreover, the prognostic role lymphopenia, blood protein levels, patient-related factors.Sixty-two stage non-small cell cancer (NSCLC) were retrospectively analyzed. Blood counts available prior to, during, after (3Gyx10). For each patient, a thoracic volume interest (VOI)...
PurposeOrganizational culture plays a major role in prioritizing diversity, equity, and inclusion (DEI) objectives by aligning individual values of employees with organizational values. However, effective strategies to create an inclusive culture, which these are aligned, remain unclear. The European Society for Radiotherapy Oncology (ESTRO) launched qualitative study, as follow-up the previous project on DEI that highlighted low levels work engagement among radiation oncology (RO)...
There is increasing evidence of cardiac toxicity thoracic radiotherapy however, it difficult to draw conclusions on dose constraints due the heterogeneity published studies. Moreover, few studies record data cause death. The aim this paper investigate relationship between conventional dosimetric parameters and death with causes using from UK national registry.Data cancer diagnosis, treatment following radical lung were obtained Public Health England for all patients treated at Christie NHS...
Severe radiation-induced lymphopenia (RIL) in patients undergoing chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is associated with decreased immunotherapy efficacy and survival. At The Christie MD Anderson Cancer Center (MDACC), prediction models were developed esophageal patients, respectively. aim of this study was to externally validate both stage III NSCLC.Patients who underwent concurrent CRT NSCLC 2019-2021 studied. Outcomes grade ≥3 4 during CRT. model predictors...
To investigate effects of radiotherapy (RT) and erlotinib on pulmonary glucose uptake using 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography (PET) during after treatment non-small cell lung cancer (NSCLC) to identify associations between serum cytokine levels uptake.Twenty-seven patients with advanced NSCLC, receiving RT alone or concomitant therapy, were examined by 18F-FDG PET before, during, treatment. A total 57 scans analyzed. Pulmonary dose mapping used acquire...
Radiation therapy effectively kills cancer cells and elicits local effects in the irradiated tissue. The aim of this study was to investigate kinetics cytokines serum patients with lung undergoing radiation identify associations metabolic tumor burden as determined by 2-deoxy-2-fluoro-D-glucose (18F-FDG) positron emission tomography (PET).Forty-five advanced non-small cell were included a phase 2 clinical trial randomized between fractionated thoracic alone or concurrent an epidermal growth...