A5074020781- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Plant-Microbe Interactions and Immunity
- Sirtuins and Resveratrol in Medicine
- Plant Pathogenic Bacteria Studies
- Banana Cultivation and Research
North Sichuan Medical University
2023
Abstract In previous studies Lysobacter enzymogenes isolate LEC exhibited broad biocontrol activity against microbial phytopathogens on different crops. The aim of the present study was to identify metabolites responsible for antimicrobial and disease-suppressive activities this isolate. Fermentation broth fractionated by preparative HPLC resulting single fractions were analyzed HPLC-ESI-MS. vitro growth suppression apparent in agar diffusion microtiter plate assays Fusarium culmorum ,...
Discovery of novel antibiotics is crucial to counteract bacterial resistance spread. Aiming expand the available arsenal last-resort glycopeptide (GPAs), we mined actinobacterial genomes Pseudonocardiales. We thus identified a biosynthetic gene cluster (BGC) encoding for GPA with peptide scaffold, not fitting into existing classification types. By cultivating producer strain, Actinokineospora auranticolor DSM 44650, an antibiotic complex-named kineomicins (Kmc)-was and characterized by...
Abstract A series of 2‐hydroxy‐4‐benzyloxylimine resveratrol derivatives was designed, synthesized and evaluated as multifunctional agents for the treatment Parkinson's disease. The results revealed that most possessed good activities. Among them, representative compound ( E )‐5‐[(4‐fluorobenzyl)oxy]‐2‐{[(4‐hydroxyphenyl)imino]methyl}phenol 7 h ) exhibited excellent MAO‐B inhibition (IC 50 =8.43×10 −3 μM) high antioxidant activity (ORAC=3.45 Trolox equivalent). Additionally, displayed metal...