A5090984331- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- BRCA gene mutations in cancer
- Reproductive Health and Contraception
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Lung Cancer Diagnosis and Treatment
- Medication Adherence and Compliance
- Pain Management and Opioid Use
- Pharmaceutical industry and healthcare
- Thyroid and Parathyroid Surgery
- Cancer Risks and Factors
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Ethics in Clinical Research
- Cancer Treatment and Pharmacology
- Advanced Radiotherapy Techniques
Yale Cancer Center
2021-2025
Yale University
2021-2025
Bristol-Myers Squibb (Germany)
2024
G1 Therapeutics (United States)
2024
Duke University
2014-2023
Duke Medical Center
2006-2022
Duke University Health System
2013-2022
VA Boston Healthcare System
2022
University of Pittsburgh
2022
Duke Cancer Institute
2015-2021
To examine the association between extent of surgery and overall survival in a large contemporary cohort patients with papillary thyroid cancer (PTC).Guidelines recommend total thyroidectomy for PTC tumors >1 cm, based on older data demonstrating an advantage over lobectomy.Adult 1.0-4.0 cm undergoing National Cancer Database, 1998-2006, were included. Cox proportional hazards models applied to measure while adjusting patient demographic clinical factors, including comorbidities,...
Cervical lymph node metastases are recognized as a prognostic indicator only in patients age 45 years or older with papillary thyroid cancer (PTC); younger than perceived to have low-risk disease. The current American Joint Committee on Cancer staging for PTC does not include cervical metastases. Our objective was test the hypothesis that presence and number of an adverse impact overall survival (OS) PTC.Adult undergoing surgery stage I (no distant metastases) were identified from National...
Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The long-term prognosis generally excellent. Due to a paucity of data, debate exists regarding benefit adjuvant radioactive iodine therapy (RAI) for intermediate-risk patients.The objective study was examine impact RAI on overall survival in PTC patients.Adult patients with who underwent total thyroidectomy with/without National Cancer Database, 1998-2006, participated study.Intermediate-risk patients, as defined by...
To describe national practice patterns regarding utilization of minimally invasive pancreaticoduodenectomy (MIPD) and compare short-term outcomes with those following open for cancer.There is increasing interest in use MIPD; however, published data are limited to single institutional experiences.Adult patients undergoing were identified from the National Cancer Database, 2010-2011. Descriptive statistics multivariable modeling employed characterize MIPD (laparoscopic or robotic)...
Context Emerging technologies, changing diagnostic and treatment patterns, changes in Medicare reimbursement are contributing to increasing use of imaging cancer.Imaging is the fastest growing expense for but has not been examined among beneficiaries with cancer.Objective To examine how those contribute overall cost cancer care.Design, Setting, Patients Analysis a nationally representative 5% sample claims from US Centers & Medicaid Services 1999 through 2008.Patients were incident breast...
Purpose Patients who undergo surgery for papillary thyroid cancer with only a limited lymph node examination are thought to be at risk potentially harboring occult disease. However, this has not been objectively quantified and may have implications subsequent management surveillance. Methods Data from the National Cancer Database (1998 2012) were used characterize distribution of nodal positivity adult patients diagnosed localized ≥ 1-cm underwent thyroidectomy one or more nodes (LNs)...
Papillary thyroid cancer (PTC) patients <45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors >1.0 cm, regardless of age.
Racial disparity in the use of prostate magnetic resonance imaging (MRI) presents obstacles to closing gaps cancer diagnosis, treatment, and outcome.To identify clinical, sociodemographic, structural processes underlying racial MRI among men with a new diagnosis cancer.This population-based cohort study used mediation analysis assess claims US Surveillance, Epidemiology, End Results (SEER)-Medicare database for 39 534 patients localized from January 1, 2011, December 31, 2015. Statistical...
Previous studies have linked the use of positron emission tomography (PET) with improved outcomes among patients non-small-cell lung cancer (NSCLC). However, this association may be confounded by PET-induced stage migration and selection bias. We examined between PET overall survival Medicare beneficiaries NSCLC.Retrospective analysis Surveillance, Epidemiology, End Results (SEER) -Medicare data was used to characterize changes in survival, stage-specific distribution NSCLC 1998 2003.A total...
Importance Improvements in cancer outcomes have led to a need better understand long-term oncologic and nononcologic quantify cancer-specific vs noncancer-specific mortality risks among survivors. Objective To assess absolute relative rates survivors of cancer, as well associated risk factors. Design, Setting, Participants This cohort study included 627 702 patients the Surveillance, Epidemiology, End Results registry with breast, prostate, or colorectal who received diagnosis between...
In 2006, the Centers for Medicare & Medicaid Services approved coverage use of 21-gene recurrence score (RS) assay in women with early-stage, estrogen receptor-positive, node-negative breast cancers to help guide recommendations adjuvant chemotherapy. Use community settings has not been previously examined a nationally representative sample patients.To examine trends RS routine clinical practice cancer.Retrospective observational study beneficiaries diagnosed incident cancer between 2005 and...
<h3>Importance</h3> Guidelines recommend consideration of chemotherapy for most patients with early-stage, estrogen receptor–positive, invasive breast cancer in the absence additional prognostic information. The 21-gene recurrence score (RS) assay has been shown limited academic settings to reduce physician recommendations adjuvant chemotherapy. Associations between adoption and receipt general population have not examined. <h3>Objective</h3> To examine whether RS a nationally representative...
Oncotype DX (ODX) is a tumor gene-profiling test that aids in adjuvant chemotherapy decision-making. ODX has the potential to improve quality of care; however, if not equally accessible across racial groups, disparities cancer care may persist or worsen. We examined testing uptake.We used data from Carolina Breast Cancer Study, phase III, longitudinal, population-based study 2,998 North women who received diagnosis breast between 2008 and 2014. Our primary analysis modified Poisson...
<h3>Importance</h3> Adequate representation of demographic subgroups in premarketing and postmarketing clinical studies is necessary for understanding the safety efficacy associated with novel cancer therapeutics. <h3>Objective</h3> To characterize compare reporting data individuals by sex, age, race used Food Drug Administration (FDA) to evaluate <h3>Design, Setting, Participants</h3> In this cross-sectional study, therapeutics approved FDA from 2012 through 2016 were identified. Study...
Over the last decade, scientific discovery and technological advances have created great anticipation for capabilities to tailor individual medical decisions provide personalized healthcare. Despite some advances, adoption has been sporadic there remains a lack of consensus about what healthcare actually means. This confusion often resulted from mistake equating medicine with genomic medicine, thereby, attributing it as yet unfulfilled expectations broader application medicine. The clear...