A5068464735- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Sepsis Diagnosis and Treatment
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Hip disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Shoulder and Clavicle Injuries
- Cancer and Skin Lesions
- Erythrocyte Function and Pathophysiology
- Machine Learning in Healthcare
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Atrial Fibrillation Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Blood groups and transfusion
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Nutrition and Health in Aging
Mass General Brigham
2020-2025
Massachusetts General Hospital
2020-2025
Center for Systems Biology
2020-2025
Melbourne Clinic
2019-2024
Harvard University
2020-2023
Stanford Medicine
1999-2021
Melbourne Health
2021
Stanford University
1998-2013
Charles River Analytics (United States)
2011
Box Hill Hospital
1999-2008
Background: Primary total hip replacement performed through an incision that is ≤10 cm in length has been advocated as a minimally invasive technique. Proponents have claimed mini-incision techniques reduce blood loss, transfusion requirements, postoperative pain, and the of hospital stay compared with standard longer incision. However, we are aware no well-designed comparison study supports these claims. The purpose present was to compare short-term results technique for replacement....
<h3>Importance</h3> Coronavirus disease 2019 (COVID-19) is an acute respiratory illness with a high rate of hospitalization and mortality. Biomarkers are urgently needed for patient risk stratification. Red blood cell distribution width (RDW), component complete counts that reflects cellular volume variation, has been shown to be associated elevated morbidity mortality in wide range diseases. <h3>Objective</h3> To investigate whether association between RDW at hospital admission during...
Fourteen patients in whom open reduction and internal fixation could not be achieved satisfactorily had a total elbow arthroplasty for non-union of supracondylar humeral fracture. All an established non-union, ten from one to four previous attempts at fixation. The average age the time operation was sixty-five years. duration follow-up five years, with minimum two preoperative score 17 points, both pain functional disability present. postoperative 84 points; there were eight good or...
Sixteen patients who received nineteen semiconstrained total elbow replacements for complete ankylosis of the were followed an average five and three-quarters years (range, two to twelve years). The preoperative score was 23 points postoperative 84 points. Postoperatively, flexion 115 degrees; extension, 35 pronation supination, 95 degrees. There fifteen excellent or good results. one failure due a deep infection, but after removal prosthesis satisfactory fascial arthroplasty achieved in...
OBJECTIVE To examine the accuracy of different periods continuous glucose monitoring (CGM), hemoglobin A1c (HbA1c), and their combination for estimating mean glycemia over 90 days (AG90). RESEARCH DESIGN AND METHODS We retrospectively studied 985 CGM with &lt;10% missing data from 315 adults (86% whom had type 1 diabetes) paired HbA1c measurements. The impact red blood cell age as a proxy nonglycemic effects on was estimated using published theoretical models in comparison empirical...
Patients with rheumatoid arthritis who had undergone total ankle arthroplasty and a minimum of 2 yr follow-up were studied. Of the original 21 patients 17 available for review. Twenty-three replacements an average 5.6 On ankles rated excellent, 13 good, 4 fair, poor. Thus, 83% satisfactory on follow-up. Radiographic analysis revealed migration settling talar component in 14 15 cases. Bone cement radiolucencies found tibial components tilting 12 these components. The postoperative position...
Abstract Objective To identify the genetic abnormality responsible for osteoarthritis (OA), avascular necrosis (AVN) of femoral head, and Legg‐Calvé‐Perthes disease in a single family, to determine factors distinct phenotypes manifested by different family members. Methods Forty‐two members 5‐generation were recruited investigated. Diagnosis was made independent orthopedic surgeons radiologists. Histopathologic changes diseased tissue examined. Linkage analysis performed with markers...
Scar cosmesis is one of the proposed benefits mini-incision total hip replacement as opposed to standard-incision procedures; however, there has been no scientific proof this clinical outcome. The cosmetic appearances healed incisions 34 primary procedures done by surgeon using either a (20 procedures) or standard-length incision (14 were compared at an average 2 years postoperatively. Each scar's appearance was graded independently two plastic surgeons standardized rating system. Patients...
Failure of total elbow arthroplasty leads to difficult and complicated surgical reconstruction. This study evaluates the results reconstruction after implant removal with respect pain, motion, functional ability. Between 1978 1985, 11 patients required removal. Indications for were infection seven, fracture three, recurrent dislocation one. The original diagnosis was rheumatoid arthritis in six elbows traumatic five. average length follow-up period 5.5 years (minimum, two years). Treatment...
Abstract Background Coronavirus disease 2019 (COVID-19) is an acute respiratory illness with a high rate of hospitalization and mortality. Prognostic biomarkers are urgently needed. Red blood cell distribution width (RDW), component complete counts that reflects cellular volume variation, has been shown to be associated elevated risk for morbidity mortality in wide range diseases. Methods We retrospectively studied the relationship between RDW COVID-19 1198 adult patients diagnosed...
Abstract Examination of red blood cell (RBC) morphology in peripheral smears can help diagnose hematologic diseases, even resource-limited settings, but this analysis remains subjective and semiquantitative with low throughput. Prior attempts to develop automated tools have been hampered by their poor reproducibility limited clinical validation. Here, we present a novel, open-source machine-learning approach (denoted as RBC-diff) quantify abnormal RBCs smear images generate an RBC...
Pregnancy alters hematologic state as measured by complete blood counts (CBC), but the longitudinal changes in CBC indices that define healthy pregnancies are not well established. Our objectives were (1) to gestational age-specific reference intervals for CBCs and their a large United States-based cohort (2) use these examine associations between extreme values risk of obstetric complications. Retrospective study including electronic health record-based discovery validation cohorts....
Echocardiography and Pulmonary Vein Ablation . Introduction : We sought to evaluate the utility of a phased‐array intracardiac echocardiography (ICE) device identify left atrial (LA) pulmonary vein (PV) anatomy; accurately guide radiofrequency ablation (RFA) right or PV ostium LA appendage (LAA); blood flow before after RFA using Doppler parameters. Methods Results Twelve adult sheep were anesthetized an Acuson 10–French, 7–MHz ICE transducer introduced via internal jugular into atrium. The...
The clinical results of semiconstrained total elbow arthroplasty have been encouraging, especially in rheumatoid arthritis. This article presents medium-term results, revision rates, and reasons for a linked device (Solar Total Elbow; Stryker, Mahwah, New Jersey). We retrospectively reviewed 17 consecutive patients operated on between February 1994 March 2001. Thirteen were available evaluation with an average follow-up 8.4 years (range, 4–12.6 years). presenting diagnosis was post-traumatic...
Background: Researchers routinely evaluate novel biomarkers for incorporation into clinical risk models, weighing tradeoffs between cost, availability, and ease of deployment. For assessment in population health initiatives, ideal inputs would be those already available most patients. We hypothesized that common hematologic markers (eg, hematocrit), an outpatient complete blood count without differential, useful to develop models cardiovascular events. Methods: developed Cox proportional...