A5030450558- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Circadian rhythm and melatonin
- Lipid metabolism and disorders
- Muscle Physiology and Disorders
- Cardiovascular and Diving-Related Complications
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Obstructive Sleep Apnea Research
- Cholesterol and Lipid Metabolism
- Muscle activation and electromyography studies
- Prosthetics and Rehabilitation Robotics
- Atrial Fibrillation Management and Outcomes
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Muscle metabolism and nutrition
- Cardiac Imaging and Diagnostics
- Peroxisome Proliferator-Activated Receptors
Humboldt-Universität zu Berlin
2018-2023
Freie Universität Berlin
2018-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018-2023
Charité - Universitätsmedizin Berlin
2018-2023
Max Delbrück Center
2023
German Centre for Cardiovascular Research
2019-2020
Heart and Diabetes Center North Rhine-Westphalia
2017
Preeclampsia is associated with increased cardiovascular long-term risk; however, the underlying functional and structural mechanisms are unknown. We investigated maternal cardiac alterations after preeclampsia. Female rats harboring human angiotensinogen gene [TGR(hAogen)L1623] develop a preeclamptic phenotype hypertension albuminuria during pregnancy when mated male bearing renin [TGR(hRen)L10J] but behave physiologically normal before pregnancy. Furthermore, were treated pravastatin....
Diabetic pregnancy is correlated with increased risk of metabolic and neurological disorders in the offspring putatively mediated epigenetically. Little known about epigenetic changes already present fetuses diabetic pregnancies. We aimed at characterizing perinatal environment after preexisting maternal diabetes mellitus identifying relevant fetus. focused on transcription factor Srebf2 (sterol regulatory element binding 2), a master gene regulation cholesterol metabolism. tested whether...
Echocardiography is the most commonly applied technique for non-invasive assessment of cardiac function in small animals. Manual tracing endocardial borders time consuming and varies with operator experience. Therefore, we aimed to evaluate a novel automated two-dimensional software algorithm (Auto2DE) animals compare it standard use manual 2D-echocardiographic (2DE). We hypothesized that Auto2DE will provide rapid robust data sets, which are agreement manually assessed animals.2DE were...
Several studies have shown that women with a preeclamptic pregnancy exhibit an increased risk of cardiovascular disease. However, the underlying molecular mechanisms are unknown. Animal models essential to investigate causes this and ability assess possible preventive therapeutic interventions. Using latest technologies such as speckle tracking echocardiography (STE), it is feasible map subclinical changes in cardiac diastolic systolic function well structural maternal heart. The aim work...
Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux downstream pathways
Diabetes in pregnancy is a major burden with acute and long-term consequences. Its treatment requires adequate diagnosis monitoring of therapy. Many experimental research on diabetes during has been performed rats. Recently, continuous blood glucose non-pregnant diabetic rats revealed an increased circadian variability that made single measurement per day inappropriate to reflect glycemic status. Continuous never pregnant We wanted perform decipher the influence normoglycemic used transgenic...
Abstract Aims/hypothesis The impact of diabetic pregnancy has been investigated extensively regarding offspring metabolism; however, little is known about the influence on heart. We aimed to characterise effects a male adult cardiac health after feeding high-fat diet in an established transgenic rat model. Methods applied our model for maternal type 2 diabetes characterised by insulin resistance with hyperglycaemia and hyperinsulinaemia. Diabetes was induced preconceptionally via...
Objective: In the field of non-treatable muscular dystrophies, promising new gene and cell therapies are being developed entering clinical trials. Objective assessment therapeutic effects on motor function is mandatory for economical ethical reasons. Main shortcomings existing measurements discontinuous data collection in artificial settings as well a major focus walking, neglecting importance hand arm movements patients' independence. We aimed to create digital tool measure muscle with an...
Several studies show an association of maternal diabetes during pregnancy with adverse offspring metabolic health. Other studies, however, suggest that this effect might be biased by obesity, which is independently associated disease and often coexistent to diabetes. We performed a prospective study in rat model test the hypothesis burden diabetic without obesity deteriorates health male offspring. generated type 2 before conception persisted knockdown insulin receptor small hairpin...
Abstract Purpose We present a methodological overview of respiration chamber at the Experimental and Clinical Research Center in Berlin, Germany. Since 2010, we investigated 750 healthy subjects patients with various diseases. routinely measure resting energy expenditure (REE), dietary-induced thermogenesis, activity expenditure. Methods The is pull calorimeter total volume 11,000 L. majority measurements done flow rate 120 L/min, yielding favorable time constant 1.53 h. gas analysis system...
<p class="first" dir="auto" id="d11340942e119">Preeclampsia (PE), the most common pregnancy disease, is main cause for maternal and fetal mortality morbidity worldwide. It characterized by a sudden increase in blood pressure combination with signs of end organ damage, e.g. proteinuria. The mechanisms how pathological leads to future cardiovascular are poorly understood, while there lack comprehensive animal models describing more nuanced biological processes heart connected immune...
Sleep-disordered breathing (SDB) represents a highly prevalent co-morbidity in patients with atrial fibrillation (Afib). Previous studies differentiate OSA from central sleep apnea (CSA) by classification of apneas only. Hence, hypopneas usually represent great proportion nocturnal respiratory events. This study investigates the impact differentiating and instead only on differentiation predominant vs. CSA.