A5056788601- Antimicrobial Peptides and Activities
- Marine Sponges and Natural Products
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Antioxidant Activity and Oxidative Stress
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Aquaculture Nutrition and Growth
- Fatty Acid Research and Health
- Protein Hydrolysis and Bioactive Peptides
- Vibrio bacteria research studies
- Eosinophilic Disorders and Syndromes
UiT The Arctic University of Norway
2008-2025
Turgencin A, a potent antimicrobial peptide isolated from the Arctic sea squirt Synoicum turgens, consists of 36 amino acid residues and three disulfide bridges, making it challenging to synthesize. The aim present study was develop truncated with an drug lead potential based on turgencin A. experiments consisted of: (1) sequence analysis prediction 10-mer sequences; (2) synthesis screening devoid cysteine residues; (3) optimization in vitro activity using replacement strategy; (4)...
ABSTRACT We have synthesised a series of 12‐residue analogues previously reported lead peptide ( P6 ) developed from the heavy chain marine EeCentrocin 1, isolated sea urchin Echinus esculentus . optimised by increasing its net positive charge, lipophilicity through N ‐terminal fatty acid acylation or incorporation Trp residue, and synthesising head‐to‐tail cyclic peptides under pseudo–high‐dilution conditions. All were screened for antimicrobial antifungal activity, toxicity was determined...
A Gram-stain-negative, facultatively anaerobic Vibrio strain, designated NFH.MB010T, was isolated from an epidermal lesion on the test (hard shell skeleton) of a green sea urchin (Strongylocentrotus droebachiensis) collected northern Norway. Cells strain NFH.MB010T were rod shaped and motile by means single, long polar flagellum. Growth observed at 1–5% NaCl (w/v) 4 °C, but not above 28 °C. Phylogenetic analyses based eight-gene multilocus sequence analysis (16S rRNA, atpA, gyrB, mreB, pyrH,...