A5017613671- Cardiac electrophysiology and arrhythmias
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Hypothalamic control of reproductive hormones
- Hedgehog Signaling Pathway Studies
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
University of Bonn
2018-2019
Transient brain insults, including status epilepticus (SE), can trigger a period of epileptogenesis during which functional and structural reorganization neuronal networks occurs resulting in the onset focal epileptic seizures. In recent years, mechanisms that regulate dynamic transcription individual genes thereby contribute to development hyperexcitable network have been elucidated. Our own results shown early growth response 1 (Egr1) transiently increase expression T-type...
Thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH<sub>2</sub>) has multiple, but transient, homeostatic functions in the brain. It is hydrolyzed vitro by pyroglutamyl peptidase II (PPII), a narrow specificity ectoenzyme with preferential localization brain, evidence that PPII controls TRH communication brain vivo scarce. We therefore studied male Wistar rats distribution of mRNA septum and consequence inhibition on analeptic effect injected into medial septum. Twelve to 14% cell profiles...
ABSTRACT Hindbrain precerebellar neurons arise from progenitor pools at the dorsal edge of embryonic hindbrain: caudal rhombic lip. These follow distinct migratory routes to establish nuclei that provide climbing or mossy fiber inputs cerebellum. Gli3, a zinc-finger transcription factor in Sonic hedgehog signaling pathway, is an important regulator brain development. We demonstrate Gli3-null mutant mice, disrupted neuronal streams lead disorganization nuclei. Precerebellar progenitors are...