A5081970545- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Virus-based gene therapy research
- Pelvic and Acetabular Injuries
- Cancer Research and Treatments
- Hernia repair and management
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Diverticular Disease and Complications
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Endometriosis Research and Treatment
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Animal Virus Infections Studies
- Urinary Tract Infections Management
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
Tongji Hospital
2013-2024
Tongji University
2013-2024
Shanghai Tenth People's Hospital
2009-2010
University Medical Center Freiburg
2001-2002
Baylor College of Medicine
1996-2001
Universitäts Frauenklinik
1994
Universität Ulm
1993
Increasing evidence suggests that the long non-coding RNA, HOX transcript antisense intergenic RNA (HOTAIR) is widely involved in progression and metastasis of cancer. However, specific role HOTAIR ovarian carcinogenesis remains to be fully elucidated. In present study, levels were detected 30 paired cancer noncancer tissues using reverse transcription-quantitative polymerase chain reaction analysis. The effect on cells was examined by overexpression or small interfering interference...
Abstract Background Anti-angiogenic therapy has become one of the effective treatment methods for tumors. Long noncoding RNAs (lncRNAs) are emerging as important regulators tumorigenesis and angiogenesis in EC. However, underlying mechanisms lncRNA TRPM2-AS EC still not clear. Methods We screened differently expressed lncRNAs that were highly associated with poor prognosis by bioinformatics analysis, constructed a ceRNA network based on prognostic lncRNAs. The subcellular localization was...
Targeted nanocarriers may offer a new approach to improve the efficacy and tolerability of cisplatin, which are commonly used treat cancers as first line chemotherapy for most types cancer. In present study, we have developed EGFR-targeted albumin-cisplatin nanoparticles tumor targeted delivery cisplatin. The cisplatin NPs were conjugated with EGFR aptamer, binded Hela cells specifically, then taken up by through receptor mediated endocytosis. aptamers accumulate in interact on surface...
Circular RNAs (circRNAs) play a role in various types of cancer. The present study suggested that hsa_circ_0026123 expression was upregulated ovarian cancer (OVA), which associated with its OVA. However, the OVA cell invasion and proliferation remains unclear. In study, tissues lines were used to investigate functions hsa_circ_0026123. associations between hsa_circ_0026123, miR‑124‑3p enhancer zeste homolog 2 (EZH2) examined using luciferase reporter assay. RT‑qPCR western blot analysis for...
Although the neutrophil membrane (NM)-based nanoparticulate delivery system has exhibited rapid advances in tumor targeting stemmed from inherited instinct, antitumor effect requires further improvement due to inefficient cellular internalization absence of specific interactions between NM-coated nanoparticles and cells.Herein, we fabricated drug-paclitaxel loaded NM camouflaging (TNM-PN) modified with necrosis factor-related apoptosis-inducing ligand (TRAIL), favorable for...
Transdermal drug delivery provides a desirable alternative method of penetrating the skin for psoriasis treatment, by virtue its ability to dampen overactivation immune cells and inflammation, while attenuating detrimental effects systemic administration. Lymph nodes (LNs), as critical organ lymphatic acquired system, are suitable sites homing suppress cells.In this context, we developed microneedle (MN) patch that delivers nanodrugs locally LNs improving antipsoriatic treatment. In study,...
In Brief Objective: Breast cancer risk is still an important topic regarding hormone therapy as well oral contraception. Evidence that progestogens may play a crucial role accumulating. Progesterone receptor membrane component 1 (PGRMC1) expressed in breast be tumorigenesis and thus increase risk. The aim of this project was to investigate the influence different estradiol (E2) concentrations addition two on MCF-7 cells overexpressing PGRMC1. Methods: were stably transfected with PGRMC1...
<b><i>Background/Aim:</i></b> We aimed to assess the value of early laparoscopic therapy in management tubo-ovarian abscess (TOA) or pelvic abscess. <b><i>Methods:</i></b> This was a retrospective study all consecutive patients who were initially diagnosed with TOA at local hospital between January 2010 and December 2014. The risks operation recurrence analyzed using logistic analyses. <b><i>Results:</i></b> durations...
Efficient delivery of small interfering RNAs (siRNAs) to the targeted cells has remained a significant challenge in clinical applications. In present study, we developed novel aptamer–siRNA chimera system mediated by cationic Au-Fe3O4 nanoparticles (NPs). The constructed VEGF RNA aptamer and Notch3 siRNA was bonded with heterogeneous electrostatic interaction. obtained complex exhibited much higher silencing efficiency against gene compared alone lipofectamine-siRNA complex, improved...
Abstract: Synthetic and biological materials are commonly used for pelvic floor reconstruction. In this study, host tissue response biomechanical properties of mesh fabricated from co-electrospun poly(L-lactide-co-caprolactone) (PLCL) fibrinogen (Fg) were compared with those polypropylene (PPM) in a canine abdominal defect model. Macroscopic, microscopic, histological, evaluations performed over 24-week period. The results showed that PLCL/Fg had similar responses but better initial...
The application of polypropylene mesh (PPM) in pelvic organ prolapse (POP) treatment was severely limited by the complications associated with PPM, such as exposure, chronic inflammatory reactions and postoperative hematoma. This study applied a method fabricating hydrogel-mesh complex (PPM + TA@GelMA) to cross-link tannic acid (TA) directly Methacrylate Gelatin (GelMA) hydrogel thus form coating for PPM. one-step modification improved hydrophilicity cyto-compatibility hemostatic effect...
The effect of androgens on the prevention or promotion cell cycle progression in ovarian and breast cancer is controversial. This determines basic rules how to treat postmenopausal patients properly after surgery. In present study, we investigated effects different androgens, namely dihydrotestosterone (DHT), testosterone dehydroepiandrosterone (DHEA) MCF-7 OVCAR-3 cells. We found that DHT could down-regulate p27, but not p21, within 4 h. Further studies proved induced p27 degradation...
Secondary infertility remains a major complication of endometrial fibrosis in women. The use exosomes from adipose-derived mesenchymal stem cells (ADSCs) has shown promising results for the treatment fibrosis. However, mechanisms action ADSC-exosome (ADSC-Exo) therapy remain unclear.An model was established mice treated with alcohol and epithelial (ESCs) TGF-β1. ADSCs were isolated Sprague Dawley (SD) rats, using ExoQuick reagent. Exosomes identified by transmission electron microscopy...
Abstract Objective and design Database screening indicated that tubulin polymerization‐promoting protein 3 (TPPP3) was involved in pathogenesis of multiple cancer types. miR‐1827 has a potential role variety human cancers. However, the TPPP3 its underlying molecular mechanism endometrial (EC) not been investigated. Herein, we aimed to reveal TPPP3/miR‐1827 EC progression. Methods Tumour tissue whole blood samples were collected for detection expression. shRNAs pcDNA‐TPPP3 applied knockdown...
Importance Standard postpartum pelvic floor muscle training (PFMT) can effectively reduce the incidence of dysfunction diseases. Objective This study aimed to evaluate adherence PFMT with smartphone application reminders on women in period. Study Design We conducted a randomized controlled trial. single-center (1:1) included primiparous admitted Tongji Hospital between March 2022 and June (ChiCTR2200059157). Every puerpera was given (PFM) assessment guidance at 6 weeks after delivery. After...