A5001741661- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Mycobacterium research and diagnosis
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Endometriosis Research and Treatment
- Glioma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Liver physiology and pathology
- Gynecological conditions and treatments
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Polydiacetylene-based materials and applications
Southern Medical University
2014-2025
Nanfang Hospital
2023-2025
National Medical Products Administration
2023-2025
Guangzhou Medical University
2018-2024
Guangzhou Medical University Cancer Hospital
2024
State Key Laboratory of Respiratory Disease
2020-2023
Zhujiang Hospital
2014-2021
First Affiliated Hospital of Guangzhou Medical University
2021
Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions cerebral ischemia remain largely unknown. Through an lncRNA array analysis rat model focal ischemia/reperfusion (I/R), we have identified CAMK2D-associated transcript 1 (C2dat1) as novel I/R-induced that regulated the expression CaMKIIδ murine models ischemia. C2dat1 mRNA was upregulated time-dependent manner mouse cortical penumbra after...
Transforming growth factor (TGF)‑β1 has a key role in the regulation of fibrosis and organ dysfunction. During pathogenesis progression vital fibrosis, microRNA (miR)‑29 family is irregularly downregulated exogenous supplementation miR‑29b strong anti‑fibrotic capacity. However, whether TGF‑β1 able to provoke endometrial miR‑29 remain unclear. In present study, RT‑qPCR, immunocytochemistry, western blot analysis, scanning electron microscopy, immunofluorescence staining, cell proliferation...
PurposeCancer-associated fibroblasts (CAFs) are an integral part of the tumor microenvironment (TME), which is involved in therapy resistance. This study aimed to investigate role CAFs radiosensitivity breast cancer cells.Methods and MaterialsThe were isolated from tissues, conditioned medium was collected culture cells. Radiation-induced DNA damage evaluated by immunofluorescence western blotting. Cytokine array enzyme-linked immunosorbent assay performed analyze secretion cytokines growth...
Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions various survival pathways. However, the mechanisms of regulation cancer remain unknown. present study, we performed a comprehensive characterization regulators 9125 tumor samples across 33 types using multi-omic data from The Cancer Genome Atlas Cell Line Encyclopedia. genomic landscape, identified heterozygous amplification...
The epidermal growth factor receptor (EGFR) is an important anti-tumor target. development of novel molecular-targeted drugs that can target the interior tumor cells and specifically silence EGFR expression valuable promising. In this work, a promising conjugate comprising methoxy-modified siRNA cyclic arginine-glycine-aspartic acid (cRGD) peptides, which selectively bind to αvβ3 integrins, was synthesized examined. To prepare cRGD-EGFR (cRGD-siEGFR), cRGD covalently conjugated 5′-end sense...
The PI3K-AKT-mTOR-signaling pathway is frequently activated in glioblastoma (GBM). Inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB)/p110β (a PI3K isoform) by RNAi substantially suppresses GBM growth with less toxicity to normal astrocytes. However, insufficient and non-specific small interfering RNA (siRNA) delivery may limit the efficacy RNAi-based therapies against GBM. Here we prepared a novel methoxy-modified PIK3CB siRNA molecule (siPIK3CB)...
Cisplatin (DDP)-based concurrent chemo-radiotherapy is a standard approach to treat locoregionally advanced nasopharyngeal carcinoma (NPC).However, many patients eventually develop recurrence and/or distant metastasis due chemoresistance.In this study, we aimed elucidate the effects of melatonin on DDP chemoresistance in NPC cell lines vitro and vivo, explored potential mechanisms.We found that cells mediated through Wnt/β-catenin signaling pathway.Melatonin not only reversed...
To develop a novel approach for increasing radiosensitivity in glioblastoma (GBM) by using targeted nanoparticles to deliver siRNA aimed at silencing the EGFR and RELA/P65 genes, which are implicated radioresistance.
Neutrophils play a key role in the tumor microenvironment (TME); however, their functions glioblastoma (GBM) are overlooked and insufficiently studied. A detailed analysis of GBM-associated neutrophil (GBMAN) subpopulations may offer new insights opportunities for GBM immunotherapy. We analyzed single-cell RNA sequencing (scRNA-seq) data from 127 isocitrate dehydrogenase (IDH) wild-type samples to characterize GBMAN subgroups, emphasizing developmental trajectories, cellular communication,...
Melanoma, a highly aggressive skin cancer, is characterized by its strong metastatic potential and resistance to standard treatments. Recent cancer research has emphasized the significance of exosomes, type extracellular vesicle particle, in mediating cell-to-cell communication driving tumor progression. Melanoma-derived exosomes contribute metastasis facilitating immune evasion, modulating microenvironment, inducing epithelial-to-mesenchymal transition. The exosomal cargos, including...
Dapagliflozin is a widely used sodium-glucose cotransporter 2 inhibitor that has been approved for the treatment of Type diabetes. In this study, we present simple and sensitive high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method simultaneous quantification dapagliflozin its metabolite, 3-O-glucuronide (D3OG). The experiments were conducted using an Agilent G6495B triple quadrupole spectrometer coupled with 1290 Infinity II HPLC system, featuring Poroshell 120...
Abstract The inherent heterogeneity of tumor cells impedes the development targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate mesenchymal subtype GBM uncover detailed characteristics, potential therapeutic strategies, and improve precision treatment patients. We integrated single-cell RNA sequencing (scRNA-seq), single-nucleus assay transposase-accessible chromatin (snATAC-seq), bulk datasets identify core gene modules, candidate drugs, key...
Hepatocellular carcinoma (HCC) is an aggressive form of cancer characterized by a high recurrence rate following resection. Studies have implicated stromal and immune cells, which part the tumor microenvironment, as significant contributors to poor prognoses HCC patients. In present study, we first downloaded gene expression datasets for patients from The Cancer Genome Atlas database categorized into low or score groups. By comparing those groups, identified differentially expressed genes...
Long non-coding RNAs (lncRNAs) have been to regulate tumor progression and therapy resistance through various molecular mechanisms.In this study, we investigated the role of lncRNAs in nasopharyngeal carcinoma (NPC) underlying mechanism.Using lncRNA arrays analyze profiles NPC para-tumor tissues, detected novel lnc-MRPL39-2:1, which was validated by situ hybridization 5' 3' rapid amplification cDNA ends.Further, its cell growth metastasis verified vitro vivo.The researchers conducted RNA...
The vascular endothelial growth factor receptor 2 (VEGFR2) is considered to be a pivotal target for anti-tumor therapy against angiogenesis of non-small cell lung cancer (NSCLC). However, effective and low-toxicity targeted therapies inhibit VEGFR2 are still lacking. Here, biRGD-siVEGFR2 conjugate comprising murine siRNA [cyclo(Arg-Gly-Asp-D-Phe-Lys)-Ahx]2-Glu-PEG-MAL (biRGD) peptide which selectively binds integrin αvβ3 receptors expressing on neovascularization was synthesized. activity...
Background: Lung cancer is the leading cause of cancer-related death globally. Hypoxia can suppress activation tumor microenvironment (TME), which contributes to distant metastasis. However, role hypoxia-mediated TME in predicting diagnosis and prognosis lung adenocarcinoma (LUAD) patients remains unclear. Methods: Both RNA clinical data from LUAD cohort were downloaded Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. univariate multivariate Cox regression analyses used...