A5041113040- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Gastroesophageal reflux and treatments
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Bariatric Surgery and Outcomes
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Hepatitis B Virus Studies
- Histone Deacetylase Inhibitors Research
- Atherosclerosis and Cardiovascular Diseases
Nanchong Central Hospital
2015-2024
Capital Medical University
2024
North Sichuan Medical University
2018-2024
Beijing Anzhen Hospital
2024
Guangzhou Medical University
2022
Tianjin First Center Hospital
2021
Tianjin Medical University
2021
Nankai University
2021
Eastern Hepatobiliary Surgery Hospital
2016-2020
Second Military Medical University
2016-2020
PurposeCancer-associated fibroblasts (CAFs) are an integral part of the tumor microenvironment (TME), which is involved in therapy resistance. This study aimed to investigate role CAFs radiosensitivity breast cancer cells.Methods and MaterialsThe were isolated from tissues, conditioned medium was collected culture cells. Radiation-induced DNA damage evaluated by immunofluorescence western blotting. Cytokine array enzyme-linked immunosorbent assay performed analyze secretion cytokines growth...
Junctional adhesion molecule-A (JAM-A) is preferentially concentrated at tight junctions and influences epithelial cell morphology migration. Epithelial-to-mesenchymal transition (EMT) the conversion process of cells into mesenchymal cells, it plays an important role in invasiveness metastasis various cancers. However, JAM-A regulating invasive behaviours human nasopharyngeal carcinoma (NPC) unknown. In this study, we found that upregulation induced EMT, whereas silencing endogenous...
Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage the course therefore carry poor prognosis. CDCA5 cell cycle regulatory protein has shown prognostic value several cancers. We retrospectively evaluated 178 patients with HCC treated curative liver resection between September 2009 2012 Nanchong Central Hospital Nanchong, Sichuan Province, China. Patients were screened for their...
Autophagy has become a promising target for cancer therapy. Fangchinoline (Fan) been shown to exert anticancer effects in some types of cancers. However, the on colorectal (CRC) and underlying mechanisms have never elucidated. More specifically, regulation autophagy CRC by Fan reported before. In present study, was found induce apoptosis autophagic flux cell lines HT29 HCT116, which reflected enhanced levels LC3-II protein p62 degradation, increased formation autophagosomes puncta LC3-II....
Aspirin has been reported to regulate lipid metabolism. However, the mechanism underlying regulation is not clear. We presently investigated aspirin's promotion of AMP-activated protein kinase (AMPK) pathway activation in human hepatoma HepG2 cells by examining AMPK expression, activation. Then we influence aspirin-promoted signaling on fatty acid oxidation cells. The results demonstrated that aspirin treatment did expression and its downstream target, Acetyl-Coenzyme A Carboxylase (ACC),...
Abstract Background Studies have shown that long noncoding RNAs and N6-methyladenosine play important roles in gastric cancer. The purpose of this study was to determine the correlation prognostic value m6A-related lncRNAs immune infiltration Methods We downloaded clinically related information RNA-Seq transcriptome data cancer patients from TCGA database. Univariate Cox regression analysis Pearson were used screen out lncRNAs. Consensus cluster divide sample into two clusters, LASSO...
Testis expression 10 (Tex10) is reported to be associated with tumorigenesis in several types of cancer types, but its role hepatocellular carcinoma (HCC) metastasis has not been investigated. In this study, the Tex10 HCC cell line and tissue microarray was determined by Western blot immunohistochemistry (IHC), respectively. RNA sequencing-based transcriptome analysis performed identify Tex10-mediated biological process. Cell Counting Kit-8, colony formation, transwell assays, xenograft...
Background: Anastomotic leakage following a radical gastrectomy is serious complication of gastric cancer and esophagogastric junction cancer. The benefit intraoperative leak testing for the prevention postoperative anastomotic has been controversial. We introduce new procedure, which combines techniques gastroscopy, air, methylene blue (GAM) testing. Our objective was to evaluate efficacy safety GAM procedure compare surgical complications patients who underwent with without using...
The impact of metabolic syndrome (MetS) on surgical outcome, mostly in patients with HBV-related hepatocellular carcinoma (HCC) who underwent hepatectomy.A propensity score matching analysis was conducted. Patients were categorized into two groups MetS-related (MetS-HCC) and 1:1 matched non-MetS-related HCC (non-MetS-HCC). Surgical outcomes compared between the groups.Seventy-four MetS-HCC 74 score-matched non-MetS-HCC selected for analysis. incidence site infection higher group than (12.16%...
The incidence of seroma and postoperative pain after Gilbert type III inguinal hernia repair is high. To reduce complications, this study investigated the clinical efficacy laparoscopic closed ring combined with a patch for indirect hernia. Through prospective randomized controlled study, total 193 patients admitted to Nanchong Central Hospital affiliated Chuanbei Medical College from May 2020 December 2021 were selected randomly divided into inner group (85 patients) non-closed (95...