Denis Losik

ORCID: 0000-0003-4886-9648
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About
Contact & Profiles
Research Areas
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Cardiac pacing and defibrillation studies
  • Cardiac Imaging and Diagnostics
  • Cardiac electrophysiology and arrhythmias
  • Heart Rate Variability and Autonomic Control
  • Cardiovascular Disease and Adiposity
  • Blood Pressure and Hypertension Studies
  • Cardiovascular Syncope and Autonomic Disorders
  • Cardiovascular Effects of Exercise
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiovascular Function and Risk Factors
  • Medical Imaging Techniques and Applications
  • Cardiac Valve Diseases and Treatments
  • Healthcare Systems and Public Health
  • Cardiovascular Issues in Pregnancy
  • Renal and Vascular Pathologies
  • Cardiac Structural Anomalies and Repair
  • Cardiac, Anesthesia and Surgical Outcomes
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Acute Myocardial Infarction Research
  • Cardiac Health and Mental Health
  • Lipoproteins and Cardiovascular Health
  • Pain Management and Treatment
  • Pulmonary Hypertension Research and Treatments

Ministry of Health of the Russian Federation
2016-2023

Meshalkin National Medical Research Center
2013-2023

Centre Hospitalier Universitaire Brugmann
2023

Université Libre de Bruxelles
2023

Federal Almazov North-West Medical Research Centre
2021

State Research Center of the Russian Federation
2012-2018

Institute of Cardiology
2018

Summit Medical Group (United States)
2018

Heart and Stroke Foundation
2018

Valley Health System
2013-2014

<h3>Importance</h3> Renal denervation can reduce cardiac sympathetic activity that may result in an antiarrhythmic effect on atrial fibrillation. <h3>Objective</h3> To determine whether renal when added to pulmonary vein isolation enhances long-term efficacy. <h3>Design, Setting, and Participants</h3> The Evaluate Denervation Addition Catheter Ablation Eliminate Atrial Fibrillation (ERADICATE-AF) trial was investigator-initiated, multicenter, single-blind, randomized clinical conducted at 5...

10.1001/jama.2019.21187 article EN JAMA 2020-01-21

Catheter Versus Surgical Ablation Introduction The aim of this prospective randomized study was to compare the efficacy and safety catheter ablation (CA) versus surgical (SA) in treatment paroxysmal persistent AF after failed initial pulmonary vein isolation procedure. Methods Results Patients with a history symptomatic previous first procedure were eligible for study. CA (n = 32) or SA redo ablation. primary endpoint recurrence atrial tachyarrhythmia at 1 year follow‐up. At 12‐month...

10.1111/jce.12245 article EN Journal of Cardiovascular Electrophysiology 2013-07-22

Catheter ablation of paroxysmal atrial fibrillation (PAF) is associated with an important risk early and late recurrence, necessitating repeat procedures. The aim this prospective randomized patient-blind study was to compare the efficacy safety cryoballoon (Cryo) versus radiofrequency (RF) PAF after failed initial RF procedure.Patients a history symptomatic previous first procedure were eligible for study. Patients Cryo or redo ablation. primary endpoint recurrence tachyarrhythmia,...

10.1111/jce.12038 article EN Journal of Cardiovascular Electrophysiology 2012-10-18

Background— The aim of this prospective randomized study was to assess whether an early reablation superior antiarrhythmic drug (AAD) therapy in patients with previous failed pulmonary vein isolation. Methods and Results— Patients paroxysmal atrial fibrillation (AF) eligible for AAD or after a previously initial isolation procedure were followed up 3 years rhythm by means implanted cardiac monitor. After the blanking period postablation, 154 had symptomatic AF recurrences (n=77) repulmonary...

10.1161/circep.113.000495 article EN Circulation Arrhythmia and Electrophysiology 2013-06-08

Summary Background Renal artery denervation ( RDN ) has provided incremental atrial fibrillation AF suppression after pulmonary vein isolation PVI in patients with the setting of drug‐resistant hypertension. Objective To assess relationship between changes mean blood pressure BP and recurrences/ burden combined . Methods All from two randomized studies symptomatic paroxysmal and/or persistent resistant hypertension who underwent ‐only (n=37) or (n=39), implantable cardiac monitor ICM...

10.1111/1755-5922.12264 article EN Cardiovascular Therapeutics 2017-04-19

AimsCardiac arrhythmias following acute myocardial infarction (AMI) can be associated with major adverse cardiovascular events. Data on the "real incidence" of post-MI are limited. We aimed to determine rate and burden cardiac by use insertable monitors (ICM) in patients preserved left ventricular ejection fraction (LVEF) after AMI.

10.1093/europace/euw344 article EN EP Europace 2016-10-11

Abstract Introduction The PREVENT AF I study demonstrated that prophylactic pulmonary vein isolation (PVI) in patients with pure typical atrial flutter (AFL) resulted substantial reduction of new‐onset fibrillation (AF) during 1‐year follow‐up as assessed by continuous implantable cardiac monitor (ICM). objective this was to assess 3‐year outcomes. Methods and results Fifty documented AFL were randomized either cavotricuspid isthmus (CTI) ablation alone (n = 25) or CTI concomitant PVI 25)....

10.1111/jce.13485 article EN Journal of Cardiovascular Electrophysiology 2018-03-23

Remote magnetic navigation (RMN) can be safely and effectively utilized in patients with difficult cardiac arrhythmias complex anatomy. Interruption of the inferior vena cava (IVC) is a rare congenital abnormality that results inability to use conventional femoral access require interventional procedures. The present case demonstrates feasibility left atrial flutter ablation using RMN via jugular approach patient interruption IVC.

10.1111/pace.14078 article EN Pacing and Clinical Electrophysiology 2020-09-24

Aim . To evaluate the relationship between clinical decision support system use (CDSS) and adherence to guidelines. Materials methods Medical records of 300 patients with atrial fibrillation hypertension from electronic medical database Almazov National Research Center were analyzed. Demographic data, as well information on anticoagulant, antiarrhythmic antihypertensive prescriptions The primary endpoint was prescribed treatment current guidelines for each three therapies. Firstly, a group...

10.15829/1560-4071-2021-4406 article EN cc-by Russian Journal of Cardiology 2021-05-22

At the present time there are a lot of implantable pacemakers, which able to replace function physiological pacemakers (sinoatrial and atrioventricular nodes). These systems currently imperfect have number limitations. They require constant monitoring maintenance due limited battery life. There risks infection system, may cause pacemaker reimplantation. Implantable devices often incompatible with other electric (metal detectors magnets in MRI scanners, as well power lines), affect operation...

10.23868/201707020 article EN Genes and Cells 2017-06-15

Objective: To evaluate the model of atrial fibrillation (AF) in mini-pigs with endocardial approach implantation CRT-P using bi-electrodes pacing through RV/LV connectors.Methods: All surgical interventions were minimally invasive and conducted under general anaesthesia. was implanted endocardially, X-ray. First electrode fixed right appendage. The second one — interatrial septum or free wall. Both them connected RV/LV. Bi-electrode stimulation realized during a week basic heart rate 150 bpm...

10.21688/1681-3472-2023-1-47-53 article EN cc-by Patologiya krovoobrashcheniya i kardiokhirurgiya 2023-03-30

Introduction : A novel cardiac gamma camera utilizes the radiopharmaceutical Iodine-123-Meta-iodobenzylguanidine ( 123 I-MIBG) to visualize sympathetic innervation. Physiological accumulation of I-mIBG provides an anatomical quantitative determination structures autonomic nervous system (ANS) with discrete uptake areas (DUA) activity located in left atrium (LA) corresponding main ganglionic plexi (GP) clusters that could not previously be visualized. Aim DUA heart patients paroxysmal atrial...

10.18087/cardio.2019.4.10249 article EN cc-by Kardiologiia 2019-04-18

Background ― Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in the field of nuclear medicine cardiology. The aim current study was to investigate scintigraphic patterns total uptake and regional distribution iodine-123 metaiodobenzylguanidine (123I-mIBG) healthy volunteers patients with atrial fibrillation (AF) using a gamma camera equipped CZT detectors. Material Methods number included subjects 30 (15 paroxysmal form AF 15 volunteers). Using novel...

10.15275/rusomj.2018.0308 article EN cc-by-nc Russian Open Medical Journal 2018-07-29
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