A5019312897- Synthesis and biological activity
- Synthesis of Organic Compounds
- Neuroscience and Neural Engineering
- Biological Stains and Phytochemicals
- Synthesis and Characterization of Heterocyclic Compounds
- GABA and Rice Research
- Bioactive natural compounds
- Quinazolinone synthesis and applications
- Bamboo properties and applications
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Morinda citrifolia extract uses
- Plant chemical constituents analysis
- Biological and pharmacological studies of plants
Universiti Sains Malaysia
2018-2022
Hospital Universiti Sains Malaysia
2017-2021
University of Technology Malaysia
2012
A total of fourteen pyrazoline derivatives were synthesized through cyclo-condensation reactions by chalcone with different types semicarbazide. These compounds characterized IR, 1D-NMR (1H, 13C and Distortionless Enhancement Polarization Transfer - DEPT-135) 2D-NMR (COSY, HSQC HMBC) as well mass spectroscopy analysis (HRMS). The tested for their antituberculosis activity against Mycobacterium tuberculosis H37Ra in vitro. Based on this activity, compound 4a showed the most potent inhibitory...
Bamboo shoot has been used as a treatment for epilepsy in traditional Chinese medicine generations to treat neuronal disorders such convulsive, dizziness and headaches. 4-hydroxybenzoic acid (4-hba) is non-flavonoid phenol found abundantly Dendrocalamus asper shoots (bamboo), fruits (strawberries apples) flowers. Kv1.4 rapidly inactivating Shaker-related member of the voltage-gated potassium channels with two inactivation mechanisms; fast N-type slow C-type. It plays vital roles...
Knoevenagel condensation reaction (KCR) and Pechmann are the simplest most widely used method to synthesize various substituted coumarins. The compounds such as 3–acetylcoumarin, 3–acetyl–7–(diethylamino)coumarin, 7–(diethylamino)–3–(1–oxobutyl)coumarin were synthesized by KCR which involved of salicylaldehyde or 4–(diethylamino)salicylaldehyde with ethyl acetoacetate, 4–(diethylamino)– butyrylacetate in presence dimethylamine a catalyst. Meanwhile, 7–hydroxy–4–methylcoumarin,...
Bamboo shoots of Dendrocalamus asper is very important for human health because its high content dietary fiber, low sugar, negligible amount fat, rich in vitamins and minerals. In search new potential antimalarial agents, the chemical constituents bamboo were evaluated againts P. falciparum strain 3D7. One metabolite, (11E,13E,17E,19E)-dimethyl-15,16-dibutoxytriconta-11,13,17,19-tetraenedioate (1) along with four known compounds; β-sitosterol (2), methyl-4-hydroxybenzoate (3),...
Two series of new 3,5-disubstituted-pyrazole-1-carbothioamides (4a-f and 5a-e) were designed synthesized through condensation reaction between chalcones thiosemicarbazides under alkaline condition via cyclocondensation reaction. The structures have been elucidated by Fourier-transform infrared (FTIR), High-resolution mass spectrometry (HRMS), one- two-dimensional nuclear magnetic resonance (NMR) analyses. These compounds assayed for in vitro anti-tuberculosis activity against Mycobacterium...