Pandanus tectorius fruits have been used as major food in Micronesia, but not fully exploited South East Asia. In Malaysia and Indonesia, P. fruit is wasted still utilized either a source of well for research. The aims the present study were to determine phytochemical content, antibacterial antioxidant activities, total phenolic content (TPC) cytotoxicity properties cores keys parts extracts against some normal (RAW L-6) cancer cell lines (HeLa, HepG2 MCF-7). Samples collected from Setiu...

Phytochemical studies on the rhizomes of Etlingera elatior have resulted in isolation 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), stigmast-4-en-3-one, stigmast-4-ene-3,6-dione, stigmast-4-en-6β-ol-3-one, and 5α,8α-epidioxyergosta-6,22-dien-3β-ol. Compounds 1 4 are new, their structures were elucidated by analysis spectroscopic data. Diarylheptanoids 1−3 found...

The methanol extract of the dried ripe fruits Alpinia rafflesiana was investigated for its DPPH free radical scavenger constituents. 2′,3′,4′,6′-Tetrahydroxychalcone (7), which has never been isolated from natural sources found to be most active as a with IC 50 value 55 μᴍ. Other known compounds this species include 5,6-dehydrokawain (1), flavokawin B (2), 1,7-diphenyl-5-hydroxy-6-hepten-3-one (3), (-)-pinocembrin (4), cardamonin (5) and (-)-pinostrobin (6). were detected using TLC...

This study examined the formulation of Microalgal Chloroform Extracts (MEs) and Silver nanoparticles (AgNPs) co-application for anticancer activity against MCF-7 4T1 cells, without affecting non-cancerous Vero cell-lines. The concentration, ratios duration treatments were optimized, flow cytometric cell cycle analyses carried out. metabolites based on Gas Chromatography-Mass Spectrometry (GC–MS) determined antioxidant activities evaluated. main compounds detected in Chlorella sp. N. oculata,...

Centella asiatica (CA) is a widely used traditional herb, notably for its cognitive enhancing effect and potential to increase synaptogenesis. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) N-methyl-D-aspartate (NMDARs) mediate fast excitatory neurotransmission with key roles in long-term potentiation which believed be the cellular mechanism of learning memory. Improved memory can an indication surface expression level these receptors. Our previous study...

Abstract Introduction Centella asiatica is an herbal plant that contains phytochemicals are widely believed to have positive effects on cognitive function. The adolescent stage a critical development period for the maturation of brain processes encompass changes in physical and psychological systems. However, effect C. has not been extensively studied adolescents. aim this study was therefore investigate extract enhancement learning memory rats. Methods locomotor activity, learning, were...

In vitro and in vivo studies of the activity Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against therapeutic target for hypercholesterolemia were done using HDL receptor (SR-BI) hypercholesterolemia-induced Sprague Dawley rats. The study showed that active fraction (CF6) obtained from ethyl acetate extract (EMD) its component 2',6',4-trihydroxy-4'-methoxybenzophenone increased SR-BI expression by 95% 60%, respectively. has proven effect EMD at 0.5 g/kgbw dosage reducing total...

Cardiovascular diseases (CVDs) are silent killers and hyperlipidemia is a high-risk factor. Morinda citrolia leaf (MCL), which commonly consumed by many cultural groups has high level of catechins, might exert antihyperlipidemic properties. In this study, the catechins profile MCL water extract was determined via HPLC ultraperformance liquid chromatography-traveling wave ion mobility-quadrupole time flight mass spectrometry (UPLC-TWIMS-QTOF). The major catechin in most widely studied with...

Pandanus tectorius fruit, a natural product rich in tangeretin and ethyl caffeate, has been reported to have potential as anti-hypercholesterolemia agent via Scavenger Receptor Class B type 1 (SR-B1) pathway. However, due its semi-polar properties, P. extract exhibits poor solubility when used medical remedy. The extract's can potentially be improved through synthesis of nanoparticles chitosan-P. fruit extract. This also increase the SR-B1 gene expression activity. To date, no studies...

Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a viable approach for the development new antidiabetic agents. With our ongoing interest towards inhibition, we have synthesized and screened series thiazoline derivatives (5a-k, 6a-f, 7a-1 & 8a-j) to find lead as potential agent. The bioactivity results showed thiazoline-based compound 7b having benzyl substituent nitrophenyl substituent-bearing 8e were identified most potent molecules with IC50 values 1.39...

The effects of Hydnophytum formicarum ethanolic extract towards lymphocyte, vero and T47d cells proliferation in vitroDavid Darwis, Triana Hertiani, Ediati Samito

Cancer is an uncontrolled growth of rapidly dividing cells. Decreased efficacy current anticancer drugs urges to further screening and investigation for a better alternative chemotherapeutics. Natural products marine origin are great sources potential new enhanced biological activities. Thus, the work aims investigate cytotoxic effects along with mode cell death exerted by SC-8, SC-9, HN-3, HN-4 HN-5 fractions prepared from Stichopus chloronotus Holothuria nobilis marine-sponge on human...

Gracilaria species are red marine macroalgae that found abundantly in Malaysia. changii from Morib, Selangor, G. nanilaensis and sp. Gelang Patah, Johor were used this study. Five compounds successfully isolated identified as hexadecanoic acid (1), cholest-5-en-3-ol (2), 2-hydroxymyristic (3), cholesteryl myristate (4) 1-(4'-methoxyphenyl)-3-(2",4",6"-trihydroxyphenyl)-3-hydroxypropanone (5) based on spectral data analysis (IR, UV, GC-MS, 'H NMR, "C HMQC HMBC). All tested for cytotoxicity...

Breast cancer is a malignant tumor with the highest incidence among women. Reduced chemotherapeutic efficacy of current anticancer drugs result in further screened for novel alternative agents natural origin. Marine secondary metabolites are promising sources unexploited that have wide structural diversity and shown variety biological activities. Therefore, main aim this study was to determine cytotoxic effects mode cell death exerted by three fractions, F-1, F-2 F-3 fractions prepared from...

The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten derivatives were synthesized and evaluated for inhibitory activities against acetylcholinesterase (AChE) butyrylcholinesterase (BChE) by Ellman’s method. Most tested showed higher on BChE than AChE, however, their overall activity weak. In contrast, three (compounds 3,6,9) good AChE more 50% at 10 μg/mL. Among them, compound 9bearing a ethyl substituent para position benzoyl ring...

Natural products play a crucial role in drug discovery. In the last decade, advent of marine natural product research has produced remarkable number compounds, particularly those isolated from sponges, with broad range activities for treatment human and animal diseases. this study, five known alkaloids namely aaptamine (1), 9-demethylaaptamine (2), 4- N-methylaaptamine (3), 9-methoxyaaptamine (4), 9-demethyloxyaaptamine (5), an uncommon amide sponge, 4-hydroxybenzamide (6) 3 β,5α-cholesterol...

Bamboo shoot has been used as a treatment for epilepsy in traditional Chinese medicine generations to treat neuronal disorders such convulsive, dizziness and headaches. 4-hydroxybenzoic acid (4-hba) is non-flavonoid phenol found abundantly Dendrocalamus asper shoots (bamboo), fruits (strawberries apples) flowers. Kv1.4 rapidly inactivating Shaker-related member of the voltage-gated potassium channels with two inactivation mechanisms; fast N-type slow C-type. It plays vital roles...

Atherosclerosis is a leading cause of death worldwide. The adverse side effects currently available drugs urge to find more effective and safe remedial agents. Alternative candidates from natural resources are great consequence in the emerging new drugs. Pandanus tectorius (Pandanaceae) was traditionally used Ayurvedic medicine cure certain diseases. Thus, current study conducted elucidate potency P. fruit as antiatherosclerosis antihypercholesterolemia agents through regulation high density...

Objective: This study aimed to investigate the anti-inflammatory activity of methanol extract and fractions bacteria associated with sponge (Haliclona amboinensis) evaluate their effect in reducing NO production inhibiting cyclooxygenase-1 (COX-1), cyclooxgenase-2 (COX-2) secretory phospholipase A2 (sPLA2) activity.Methods: All bacterial isolates were cultured supernatants collected for extraction secondary metabolites using diaion HP-20 obtain extracts. Evaluation cytotoxicity property was...

Excess reactive oxygen species can cause oxidative stress and lead to the progression of cardiovascular diseases. Pandanus tectorius fruit (PTF) is a promising source herbal medicine with antioxidant activity. However, oral administration hindered due semi-polar properties extract. The solubility extract be potentially improved through synthesis self-nanoemulsifying drug delivery system (SNEDDS). This study aims formulate nanoemulsion by means self-nanoemulsification approach using caprylic...