A5056938077- Enzyme function and inhibition
- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Microbial Applications in Construction Materials
- Streptococcal Infections and Treatments
- Impact of Technology on Adolescents
- Synthesis and Characterization of Heterocyclic Compounds
- Child Development and Digital Technology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vibrio bacteria research studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Technology Use by Older Adults
- Medicinal Plants and Neuroprotection
- Global Financial Crisis and Policies
- Multicomponent Synthesis of Heterocycles
- Legionella and Acanthamoeba research
- Luminescence and Fluorescent Materials
- Health and Wellbeing Research
- Carbohydrate Chemistry and Synthesis
- Otolaryngology and Infectious Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Molecular Sensors and Ion Detection
- Natural Antidiabetic Agents Studies
University of Windsor
2022-2025
The Women University Multan
2020-2022
Liaquat National Hospital
2021-2022
National Institute of Cardiovascular Diseases
2021
Bahauddin Zakariya University
2020-2021
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2018
Government College University, Faisalabad
2017
Jinnah Medical & Dental College
2017
Fatima Jinnah Women University
2016
Jamia Millia Islamia
2016
Fluorescent-small molecules offer an excellent source of chemosensors when optimized for detection anions with sensitivity and selectivity, low-cost robust synthesis.
Smartphone use is being investigated as a potential behavioral addiction. Most of the studies opt for subjective questionnaire-based method. This study evaluates psychological correlates excessive smartphone use. It uses telemetric approach to quantitatively and objectively measure participants' use.One hundred forty consenting undergraduate postgraduate students using an Android at tertiary care teaching hospital were recruited by serial sampling. They pre-tested with Addiction Scale-Short...
Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. When is non-functional may also be undergoing uncontrolled cell growth (due to other mutations), cancer readily emerges. Consequently, restoring the function misregulated and mutated an incredibly important goal therapeutic oncology. mutations often induce conformational changes inhibit protein’s ability engage its...
Pakistan has depended much on foreign debt to manage its balance of payments deficit. The heavy dependence became uncontrollable in the late 1980’s. main aims this paper are explore impact economic growth Pakistan. To achieve objective, data was collected from different sources for period 1980-2021. variables selected study included GDP per capita as dependent variable while debt, direct investment, gross capital formation and trade openness independent variables. This used statistical...
Aim: Indole is an important component of many drug molecules, and its conjugation with thiosemicarbazone moiety would be advantageous in finding lead compounds for the development diabetic complications. Methodology: We have designed, synthesized evaluated a series 17 indole-thiosemicarbazones (3a-q) as aldose reductase (ALR2) aldehyde (ALR1) inhibitors. Results: After vitro evaluation, all showed significant inhibition against both enzyme ALR1 ALR2 IC50 range 0.42-20.7 1.02-19.1 μM,...
This study delineates the design and synthesis of a series xanthene-based thiosemicarbazones that show low μM inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE), crucial enzymes associated with, among others, Alzheimer’s Disease (AD) pathology. Despite FDA-approved AChE inhibitors being frontline treatments for AD, there remains need agents exhibiting improved efficacy selectivity. Our synthesized demonstrate meaningful against (IC50 ranging from 4.2 to 62 μM). These...
Objectives: The objective of this study was to determine the level adherence and possible barriers secondary prophylaxis among patients with Rheumatic heart disease (RHD).
 Methodology: It is a cross-sectional conducted at largest tertiary care cardiac center Karachi, Pakistan. We included RHD, based on transthoracic echocardiography were assessed using structured questionnaire.
 Results: Among total 195 66.7% (130) female, mean age 32.25 ± 13.78 years. Rural residents 51.3% (100)...
Background: Since 2005 Neagleria Flowri infection appeared as a major health issue in Karachi, Pakistan.Most infections were acquired due to swimming fresh water, ablution with stagnant water.Our objective was assess the knowledge of medical students regarding this important and highlight any deficiencies education system.Material methods: It prospective cross sectional study conducted at college Pakistan.The sample size calculated sampling technique randomized stratified sampling.Knowledge...
Purpose: To investigate the antibacterial and α-glucosidase inhibitory activities of hydrazone derivatives (8a-h) ethyl isonipecotate.Methods: The reaction isonipecotate (2) with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (1) in an aqueous basic medium yielded 1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]piperidin-4- carboxylate (3). Compound 3 was subsequently converted to 1-[(3,5-dichloro-2-ethoxyphenyl) sulfonyl]piperidin-4-carboxylate (5) via O-alkylation. 5 on hydrated hydrazine...
Background Hypothyroidism can be a cause of sinus bradycardia. However, thyroid laboratory evaluation is often performed routinely in patients with complete heart block (CHB) though there little data to support this practice. This study aimed assess the frequency dysfunction presenting CHB without clinical features hypothyroidism. Methodology All referred for permanent pacemaker implantation were included cross-sectional study. Patients known disorder or excluded. Demographic,...
Objectives: The objective of this study was to determine the demographic profile and clinical characteristics newly diagnosed mitral stenosis (MS) patients. Methodology: In descriptive cross-sectional study, patients between 15 65 years age with MS were included. Data regarding characteristics, presentation, risk factors, predisposing echocardiographic findings obtained. Results: A total 125 included, overall mean 34.12±12.33 years, 61.6% (77) from rural areas, 66.4% (83) females. Only 18.4%...