A5002971415- Probiotics and Fermented Foods
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Production and Characterization
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Renal and related cancers
- Proteins in Food Systems
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Animal Diversity and Health Studies
- Meat and Animal Product Quality
- Renal cell carcinoma treatment
- Digestive system and related health
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Chemotherapy-induced organ toxicity mitigation
- Chemotherapy-induced cardiotoxicity and mitigation
- Neutropenia and Cancer Infections
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Food Industry and Aquatic Biology
- Neuroendocrine Tumor Research Advances
- Minerals Flotation and Separation Techniques
Nizhny Novgorod Regional Clinical Oncology Center
2013-2023
All-Russian Scientific Research Institute of Refrigeration Industry
2020-2021
Nizhny Novgorod Regional Clinical Hospital named after Semashko
2019
The ratio of the milk-clotting activity (MCA) and proteolytic (PA) was compared for enzyme preparations (MEP) based on recombinant chymosin, chymosin animal origin microbial origin. MCA value measured in international units (IMCU), PA determined by Anson method substrate from hemoglobin at 30 °C рН 5.3. It found that chymosins had highest level MCA/ PA: group with < ~1000 includes MEPs Chy-max® Extra 2235 Powder, 600 Liquid Renifer® 1800; 1400 M 1000, Maxiren® 1800 Chymax® Powder; > 3500 MEP...
The effect of milk-clotting enzymes (MCEs) animal origin (Naturen Extra with a mass fraction chymosins 95%, “Bovine Pepsin” chymosin 10%), as well MCEs microbial (Fromase 750 XLG) and recombinant (Chy-max Chy-max Supreme) on the duration milk coagulation processing cheese curd, composition whey fresh cheeses in manufacture semihard cheeses, at an introduction dose MCE 1,500 to 6,000 IMCU per 100 kg milk. Increasing from 2,000–3,000 IMCU/100 leads decrease by average 20 min (p<0.05). A...
The method based on the determination of amount active amino groups using o-Phthaldialdehyde (OPA method) can be applied in practice to assess accurately degree proteolysis cheeses. work establishes that OPA gives results strictly correlate (R2 > 0.80, p < 0.01) with assessing by Kjeldahl method. method, expressed absorption intensity colored sample at a wavelength 340 nm (OD340), converted content soluble nitrogenous substances cheese (WSN), calibration relationship between these...
e20593 Background: Pegfilgrastim (conjugate of filgrastim and 20 kDa polyethylene glycol (PEG) is approved for treatment chemotherapy-associated neutropenia. BCD-017 (empegfilgrastim) a covalent conjugate with 30 PEG. Increased molecular weight PEG molecule may provide additional benefits compared to pegfilgrastim. Methods: To compare efficacy safety at 3 mg 6 doses an open-label, randomized, active-comparator, non-inferiority trial was conducted. 60 patients histologically or cytologically...
A comparative test was carried out for milk-clotting enzymes (MCE) of animal origin (Naturen® Extra), microbial (Marzyme®) and MCE based on recombinant camel chymosin (Chy-max® M) in the production soft cheese “Lyubitelskiy”. By end shelf life cheeses (12 days at a temperature 3 ± 1 °C), differences were noted degree proteolysis (DP) value complex modulus G*, which following ones produced with brands: Naturen® — DP = 17.86 0.24%; G* 4164 587 Pa; Marzyme® 17.98 0.49%; 4581±786 Chy-max® M 9.85...
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The effect of the type and dose milk-clotting enzymes (Chy-max® M based on recombinant camel chymosin, Fromase® TL Rhizomucor miehei protease) physicochemical, functional properties shelf life pizza-cheeses was studied. When using a low (MCE) for milk coagulation (250–1100 IMCU per 100 kg milk), cheeses were obtained with an increased moisture content (55–57%), excessive acidity (pH 4.8–4.9) texture defects (incoherent, crumbly, separation free moisture). This is due to formation weak curd,...
e13035 Background: EMPOWER trial demonstrated the benefit of eribulin administrated post CD4/6i in patients (pts) with HR+ HER2-negative (HR+HER2-) metastatic breast cancer (MBC). There are several important limitations to this trial: > 60% pts were stage IV at time treatment initiation, used late lines (2L only 30% pts) and follow-up data immature. Current study aimed provide additional on real-world effectiveness safety monotherapy setting. Methods: Observation standard regimen enrolled...
Background: Defects in DNA damage recognition and repair has been implicated hereditary breast cancer (BC). Several studies demonstrated, that Fanconi Anemia (FA) associated genes-coding proteins products of BRCA1/2 genes cooperate a pathway which is required for resistance to interstrand crosslinks. Our aim was analyze nucleotide variants FA predisposing with an increased risk cancers. Methods: Targeted NGS performed cohort 630 BC patients strong evidence background cancer. The...
Aim. The aim of the study is to examine efficacy and safety eribulin in HER2-negative metastatic breast cancer (BC) Russian clinical practice. Materials methods. analysis included 459 patients with advanced BC from 44 federal municipal medical clinics Russia received at least 2 courses treatment accordance registered indications for drug. average age women was 56 years (between 29 81 years), 83% had tumor subtype (49.9% - luminal 33.1% triple-negative BC) HER2-positive biological 17%...
Purpose : an assessment of efficacy and safety cabozantinib in unselected patients with metastatic renal cell carcinoma the first subsequent lines therapy. Materials methods . Russian multicenter observational study included 92 consecutive morphologically verified treated (60 mg/d) 16 centers. Median age was 56 (19-79) years, a male-to-female ratio - 3:1. At start therapy 27.2 % had ECOG PS 2. Most common histological type kidney cancer clear-cell RCC (90.2 %). were diagnosed synchronous...
Тошнота — это неприятное, безболезненное, субъективное ощущение, предшествующее рвоте. Рвота рефлекторный акт выталкивания содержимого желудка через рот. и рвота являются одним из наиболее частых побочных эффектов химиотерапии (ХТ) существенно ухудшают качество жизни пациентов.
644 Background: an assessment of efficacy and safety lenvatinib in combination with everolimus unselected patients metastatic renal cell carcinoma (mRCC) progressed during or following ≥1 line antiangiogenic targeted therapy. Methods: Russian multicenter observational study included 73 consecutive morphologically verified mRCC therapy, treated (18 mg/d) (5 20 centers. Median age the was 59 (23-73) years, a male-to-female ratio - 3:1. Most common histological type kidney cancer clear-cell RCC...
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The spectrophotometric method for measuring protein content can be used to evaluate the degree of proteolysis in cheeses. At a wavelength 280 nm, tryptophan and tyrosine are absorbed, high amount them is found casein, main cheese mass. It was that value absorbance coefficient solution proteins extracted from flavoring additives with flavor (FA) cheeses depends on mass differs FA different types highest observed samples A1%1cm = 10.30, which 65 81% converted into soluble state. In cheeses, 23...
Fluoropyrimidines (5-fluorouracil, capecitabine) are the main chemotherapeutic agents in treatment of gastrointestinal oncologic pathology. However, therapy with these drugs may be associated development cardiotoxic effects. The article discusses risk factors, proven mechanisms effects development; possible measures primary and secondary prevention, peculiarities fluoropyrimidines cardiotoxicity outlined. Clinical cases presented that demonstrate complexity pathophysiological...