A5040012683- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Alzheimer's disease research and treatments
- Neurological Complications and Syndromes
- Protein Structure and Dynamics
- Boron Compounds in Chemistry
- Graphene and Nanomaterials Applications
- Quantum Dots Synthesis And Properties
- Pharmacological Effects and Toxicity Studies
- Advanced biosensing and bioanalysis techniques
- Medical Imaging Techniques and Applications
- Graphene research and applications
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- Middle East Politics and Society
- S100 Proteins and Annexins
- Machine Learning in Materials Science
- Diamond and Carbon-based Materials Research
- Nuclear Physics and Applications
- Jewish and Middle Eastern Studies
- Middle East and Rwanda Conflicts
Centre National de la Recherche Scientifique
2019-2025
Université de Montpellier
2025
Institut de Chimie Séparative de Marcoule
2025
École Nationale Supérieure de Chimie de Montpellier
2025
CEA Marcoule
2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2025
Université Claude Bernard Lyon 1
2019-2023
Institut Lumière Matière
2019-2023
University of Split
2020-2022
Forum Réfugiés - Cosi
2019-2021
Atomically precise gold nanoclusters are a fascinating class of nanomaterials that exhibit molecule-like properties and have outstanding photoluminescence (PL). Their ultrasmall size, molecular chemistry, biocompatibility make them extremely appealing for selective biomolecule labeling in investigations biological mechanisms at the cellular anatomical levels. In this work, we report simple route to incorporate preformed Au25 nanocluster into model bovine serum albumin (BSA) protein. A new...
In photodynamic therapy (PDT), light-sensitive photosensitizers produce reactive oxygen species (ROS) after irradiation in the presence of oxygen. Atomically-precise thiolate-protected gold nanoclusters are molecule-like nanostructures with discrete energy levels presenting long lifetimes, surface biofunctionality, and strong near-infrared excitation ideal for ROS generation PDT. We directly compare thiolate-gold macromolecular complexes (Au10) atomically-precise (Au25), investigate...
We report the second harmonic scattering and its orientation-averaged hyperpolarizability from mass characterized 2D graphene oxide sheets dispersed in an aqueous suspension.
The properties of atomically precise noble metal nanoclusters can be modified by the addition other metals, which may offer augmented characteristics, making them more suitable for real-life applications. In this work, we report effects single platinum atom doping a class silver protected dithiolated ligands on their optical both in linear and nonlinear (NLO) regimes stability over time. Pt Ag29 preserves NLO (in particular two-photon excited photoluminescence).
Gold nanoclusters (Au NCs) are an emerging class of luminescent nanomaterials but still suffer from moderate photoluminescence quantum yields. Recent efforts have focused on tailoring their emission properties. Introducing zwitterionic ligands to cap the metallic kernel is efficient approach enhance one-photon excitation fluorescence intensity. In this work, we extend concept nonlinear optical regime, i.e., two-photon fluorescence. For a proper comparison between theory and experiment, both...
Templating mechanism of S100A9 amyloids on Aβ fibrillar surfaces during amyloid co-aggregation process was revealed by synergy biophysical methods including charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
Four orders-of-magnitude enhancement in two-photon excited photoluminescence of gold nanoclusters has been observed following complexation with zinc ions.
Abstract The self-assembly of the cobalta bis(dicarbollide) (COSAN) anionic boron clusters into micelles above a critical micelle concentration (cmc) 10 - 20 mM and its behavior as “sticky nano-ions” facilitating controlled protein aggregation have been previously investigated using scattering techniques, particularly small-angle neutron X-ray scattering. These techniques effectively provide average structural parameters but, when applied to colloidal systems, often rely on models assuming...
Unique physicochemical features place gold nanoclusters at the forefront of nanotechnology for biological and biomedical applications. To date, information on interactions with macromolecules is limited restricts their use in living cells. Methods: Our multidisciplinary study begins to fill current knowledge gap by focusing lysosomes associated pathways U251N human glioblastoma We concentrated lysosomes, because they are intracellular destination many nanoparticles, regulate cellular...
Atomically precise, ligand-protected gold nanoclusters (AuNCs) attract considerable attention as contrast agents in the biosensing field. However, control of their optical properties and functionalization surface ligands remain challenging. Here we report a strategy to tailor AuNCs for precise detection protein carbonylation-a causal biomarker ageing. We produce Au15SG13 (SG glutathione) with atomic precision functionalize it thiolated aminooxy moiety impart carbonyl-binding properties. Mass...
The ability of gold(<sc>i</sc>) thiolates to self-assemble into supramolecular architectures opens the route for a new class nanomaterials with unique structure–optical property relationship.
Ultra-small gold nanoclusters are atomically precise structures that modulate organelles and redox-responsive transcription factors in human primary astrocytes.
We report the chemical substitution-mediated doping of silver atoms into Au10SG10 (SG: glutathione) catenane nanoclusters (NCs) in a controllable manner. Two levels were conducted leading to two silver-doped Au10–xAgxSG10 (with x = 0–2 and 1–4). Optical studies reveal that with high level (x 1–4) show blue shift absorption significant red ∼50 nm two-photon-excited emission spectrum respect pristine Au10SG10. The preservation structure is confirmed by comparing experimental computational...
Abstract This paper describes the development of a novel method producing nanocomposites consisting gold nanoclusters anchored on graphene oxide nanosheets in cost-effective and reproducible manner. The novelty technique hinges covalent functionalization atomically precise subnanometer clusters protected by glutathione (Au 15 SG 13 Au 25 18 ) to (GO) according 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride crosslinking method, using existing carboxylic groups present both at...
Abstract Atomically precise gold nanoclusters (Au NCs) are a fascinating class of nanomaterials that exhibit molecule-like properties and have outstanding photoluminescence (PL), which is highly dependent on their structure chemical environment. Their ultrasmall size, molecular chemistry, biocompatibility make them extremely appealing for selective biomolecule labeling in investigations biological mechanisms at the cellular anatomical levels. In this work, we report simple route to...
The mechanism of amyloid co-aggregation and its nucleation process are not fully understood in spite extensive studies. Deciphering the interactions between proinflammatory S100A9 protein Aβ 42 peptide Alzheimer’s disease is fundamental since inflammation plays a central role onset. Here we use innovative charge detection mass spectrometry (CDMS) together with biophysical techniques to provide mechanistic insight into differentiate complexes at single particle level. Combination...