Longitudinal intrafascicular electrodes (LIFEs) are designed to be placed inside the peripheral nerve improve stimulation selectivity and increase recording signal-to-noise ratio. We evaluated functional morphological effects of either Pt wire LIFEs or polyimide-based thin-film implanted in rat sciatic for 3 mo. The newly more flexible, can micromachined allow placement active electrode sites than conventional LIFEs. Functional results at 1 mo indicated an initial decline conduction velocity...

We present the results of a 5-year patient follow-up after implantation an original neuroprosthesis. The system is able to stimulate both epimysial and neural electrodes in such way that complete flexor–extensor chain lower limb can be activated without using withdrawal reflex. demonstrate standing assisted walking are possible, have remained stable for 5 years. Nevertheless, some problems were noted, particularly regarding muscle response on channels. Analysis electrical behaviour...

It is currently not possible to record electromyographic (EMG) signals from many locations concurrently inside the muscle in a single wire electrode system. We developed thin-film system for multichannel intramuscular EMG recordings. The was fabricated using micromachining process, with silicon wafer as production platform polyimide-based electrodes. In current prototype, flexible polymer structure 220 microm wide, 10 thick, and 1.5 cm long, it has eight circular platinum-platinum chloride...

Electroencephalography (EEG) is a standard tool for monitoring brain states in humans. Understanding the molecular and cellular mechanisms underlying diverse EEG rhythms can be facilitated by using mouse models under molecular, pharmacological, or electrophysiological manipulations. The small size of brain, however, poses severe limitation spatial information EEG. To overcome this limitation, we devised polyimide based microelectrode array (PBM array) with nanofabrication technologies....

Existing nerve monitoring devices in thyroid surgery are ‐ except for one mainly intermittently working identification tools. We present a new vagal electrode which allows true continuous of the recurrent laryngeal (RLN). The was designed as tripolar hybrid cuff consisting polyimide, gold and platinum layers embedded flexible silicon can be opened at long side introducing nerve. It is fully implantable atraumatic. evoked potentials sensed by standard electrodes. Real‐time signal analysis...

The fiber volume fraction significantly influences the mechanical properties of fiber-reinforced composites. However, accurate measurements can be particularly challenging in natural polymers. This study compares indirect methods using gravimetric and volumetric with a U-Net-based direct method micro-CT images for flax polymers made via compression molding at 2.33–13.5 bar. A notable discrepancy was observed between methods, latter yielding approximately 25% lower than what...

The fiber volume fraction significantly influences the mechanical properties of fiber-reinforced composites. However, accurate measurements can be particularly challenging in natural-fiber-reinforced polymers. This study compared indirect methods using gravimetric and volumetric with a U-Net-based direct method micro-CT images for flax-fiber-reinforced polymers made via compression molding at 2.33–13.5 bar. A notable discrepancy was observed between methods, latter yielding approximately 25%...

This paper reports on the design, in vitro and vivo investigation of a flexible, lightweight, polyimide based implantable sieve electrode with hybrid assembly multiplexers polymer encapsulation. The integration enables us to connect large number electrodes using few input connections. implant electronic circuitry was verified by impedance measurement. 27 platinum were coated black reduce impedance. magnitude sites (geometric surface area 2,200 microm(2)) |Z(f=1kHz)| = 5.7 kOmega. electrodes,...

Longitudinal intrafascicular electrodes (LIFEs) designed to be placed inside a peripheral nerve seem adequate devices for constituting nerve-prosthesis interface. In this study we evaluated the functional and morphological effects of newly polyimide-based thin-film (tf-)LIFEs implanted in rat sciatic 3 months. The tf-LIFEs used are highly flexible, have 8 regularly spaced contacts, 4 at each side folded structure. Functional results 1 month showed mild decline conduction velocity amplitude...

Parylene C is a biocompatible polymer that has been investigated as an encapsulation material for implantable microsystems. Since parylene deposited directly on the substrate from vapor phase it can conform to wide range of geometries. However, thickness layer tends decrease in microscale gaps, which might lead insulation failure. To ensure more robustness coating, changes coating have experimentally using simple gaps known dimensions. In attempt better understand these experimental...

Implantable microelectrodes represent the direct interface between biological tissue and technical systems. Different designs like cuff, shaft, sieve, needle electrodes were developed. The results of different compared discussed. Microfabrication methods enable design novel kinds including active electronics. Integrated electronic circuitry can reduce number connection lines to electrode increase signal quality. This paper presents some examples production technology neural prostheses for...

In this paper, a new approach aimed at improving the performance of intraneural longitudinal interfaces (tf-LIFEs) with peripheral nervous system (PNS) is presented. Our goal to develop movable interface by embedding microactuators into flexible tf-LIFEs structure. way, optimal position electrical contacts can be searched inside PNS and lost connections neural cells could replaced. For purpose thin film shape memory alloy (tf-SMA) was selected. A multisegmented SMA realized embedded between...

Introduction. Continuous intraoperative neuromonitoring (CIONM) via vagal nerve stimulation allows real-time surveillance of the recurrent laryngeal during thyroid surgery. However, for effective CIONM, subtle changes in conductivity have to be detected. A newly developed electrode that provides stable and safe application is presented. Methods. For validation, current distribution was simulated with finite element method. Mechanical characteristics were assessed through bench testing....

Vibrational emission (around 4.8 \ensuremath{\mu}m) of C${\mathrm{N}}^{\ensuremath{-}}$ defects was detected and studied at 80 K in 12 different alkali halide hosts. By pumping the weak overtone absorption (at \ensuremath{\sim} 2.4 intracavity a tunable ${F}_{B}(\mathrm{II})$ center laser, excitation spectra, relative intensities, lifetime values vibrational were measured all Variation defect concentration showed existence strong nonradiative luminescence quenching processes concentrations...

Intra-operative neuromonitoring is increasingly applied in several surgical disciplines and has been introduced to facilitate pelvic autonomic nerve preservation. Nevertheless, it considered a questionable tool for the minimization of risk, as results are variable might be misleading. The aim present experimental study was develop an intra-operative system with improved reliability monitoring function.Fifteen pigs underwent low anterior rectal resection performed under stimulation...

The development of interfaces that link the human nervous system with robotic devices or man-made has been a main area research for several groups in world. These focus on restoration motor and sensory function to those degenerative diseases, injury amputees. A key component is these systems fast, intuitive, bidirectional interface between biological mechatronic allows limb be controlled as if it were natural part body. Current hand prostheses use electromyographic (EMG) signals, but are...

Cervical (c) and ocular (o) vestibular evoked myogenic potentials (VEMPs) provide important tools for measuring otolith function. However, two major drawbacks of this method are encountered in clinical practice. First, recording oVEMPs is compromised by small n10 amplitudes. Second, VEMP analysis currently based on the averaging technique, resulting a loss information compared to single sweep analysis. Here, we: 1) developed novel electromotive trigger mechanism evoking VEMPs bone-conducted...