A5006197750- Microbial Natural Products and Biosynthesis
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Retinal and Optic Conditions
- Antimicrobial Resistance in Staphylococcus
- Eicosanoids and Hypertension Pharmacology
- Natural product bioactivities and synthesis
- Enzyme Structure and Function
- Tea Polyphenols and Effects
- Microbial Metabolism and Applications
- Biochemical and biochemical processes
- Synthesis of Indole Derivatives
- Polyamine Metabolism and Applications
- Hormonal Regulation and Hypertension
- Plant Gene Expression Analysis
- Retinal Imaging and Analysis
- Pharmacogenetics and Drug Metabolism
- Retinal Diseases and Treatments
- Crystal structures of chemical compounds
- Enzyme Catalysis and Immobilization
University of Oklahoma
2020-2024
The University of Texas Southwestern Medical Center
2023
Southwestern Medical Center
2023
University of Central Arkansas
2017
University of Arkansas for Medical Sciences
2017
Hendrix College
2017
Daptomycin is a last resort antibiotic for the treatment of infections caused by many Gram-positive bacterial strains, including vancomycin-resistant Enterococcus (VRE) and methicillin- Staphylococcus aureus (MRSA VRSA). However, emergence daptomycin-resistant strains S. in recent years has renewed interest synthesizing daptomycin analogs to overcome resistance mechanisms. Within this context, three aromatic prenyltransferases have been shown accept as substrate, resulting prenylated analog...
Abstract Aromatic prenyltransferases are known for their extensive promiscuity toward aromatic acceptor substrates and ability to form various carbon-carbon carbon-heteroatom bonds. Of particular interest among the is NphB, whose geranylate cannabinoid precursors has been utilized in several vivo vitro systems. It therefore established that can be as biocatalysts generation of useful compounds. However, recent observations non-native alkyl-donor indicate role NphB biocatalysis could expanded...
Coumadin (rac-warfarin) is the most commonly used anticoagulant in world; however, its clinical use often challenging because of narrow therapeutic range and interindividual variations response. A critical contributor to uncertainty variability warfarin metabolism, which includes mostly oxidative but also reductive pathways. Reduction each enantiomer yields two alcohol isomers, corresponding four alcohols retain varying levels activity. Studies on kinetics reduction have lacked resolution...
Abstract The widespread utility of isoprenoids has recently sparked interest in efficient synthesis isoprene‐diphosphate precursors. Current efforts have focused on evaluating two‐step “isoprenol pathways,” which phosphorylate prenyl alcohols using promiscuous kinases/phosphatases. convergence isopentenyl phosphate kinases (IPKs) these schemes prompted further speculation about the class's synthesizing non‐natural isoprenoids. However, substrate promiscuity IPKs general been largely...
Abstract Isopentenyl phosphate kinases (IPKs) have recently garnered attention for their central role in biocatalytic “isoprenol pathways,” which seek to reduce the synthesis of isoprenoid precursors two enzymatic steps. Furthermore, natural promiscuity IPKs toward non‐natural alkyl‐monophosphates (alkyl‐Ps) as substrates has hinted at isoprenol pathways' potential access novel isoprenoids with potentially useful activities. However, only a handful IPK crystal structures been solved date,...
Isopentenyl phosphate kinases (IPKs) catalyze the ATP-dependent phosphorylation of isopentenyl monophosphate (IP) to diphosphate (IPP) in alternate mevalonate pathways archaea and plant cytoplasm. In recent years, IPKs have also been employed artificial biosynthetic called "(iso) prenol pathways" that utilize promiscuous sequentially phosphorylate (iso) generate isoprenoid precursors IPP dimethylallyl (DMAPP). Furthermore, garnered attention for their impressive substrate promiscuity toward...
Abstract Aza‐substitution, the replacement of aromatic CH groups with nitrogen atoms, is an established medicinal chemistry strategy for increasing solubility, but current methods accessing functionalized azaindoles are limited. In this work, indole‐alkylating prenyltransferases (PTs) were explored as a to directly functionalize azaindole‐substituted analogs natural products. For this, series aza‐L‐tryptophans (Aza‐Trp) featuring N ‐substitution every position indole ring and their...
To assess diabetic macular edema (DME) progression during the early phases of COVID-19 pandemic, when severe societal restrictions raised concern possible deterioration health in patients with systemic conditions, particularly those requiring frequent office visits.
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