A5072547245- Pharmacogenetics and Drug Metabolism
- Plant-based Medicinal Research
- Tryptophan and brain disorders
- DNA Repair Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Plant Diversity and Evolution
- Ecology and Vegetation Dynamics Studies
- Meta-analysis and systematic reviews
- Reproductive Physiology in Livestock
- Reproductive tract infections research
- Plant Pathogens and Fungal Diseases
- Plant Virus Research Studies
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Inflammatory mediators and NSAID effects
- Forensic Toxicology and Drug Analysis
- Bacteriophages and microbial interactions
- Reproductive System and Pregnancy
- Alkaloids: synthesis and pharmacology
- Cannabis and Cannabinoid Research
- HIV Research and Treatment
University of Arkansas for Medical Sciences
2014-2022
Hendrix College
2014-2021
Conway School of Landscape Design
2014-2021
University of Central Arkansas
2017
Arkansas Children's Hospital
2016
Arkansas Children's Nutrition Center
2016
Objective: Although bone marrow, liver, thymus (BLT)-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most develop graft versus host disease (GVHD), limiting their utility extended HIV studies. This study aimed to: evaluate the GVHD-resistant C57 black 6 (C57BL/6) recombination activating gene 2 (Rag2)−/−γc−/−CD47−/− triple knockout (TKO)-BLT mouse as to establish latency. Determine whether TKO-BLT...
Overexpression of the translesion synthesis polymerase hpol κ in glioblastomas has been linked to poor patient prognosis; however, mechanism promoting higher expression these tumors remains unknown. We determined that activation aryl hydrocarbon receptor (AhR) pathway glioblastoma cells leads increased mRNA and protein levels. blocked nuclear translocation DNA binding by AhR using a small-molecule observed decreased expression. Pharmacological inhibition tryptophan-2,3-dioxygenase (TDO),...
ABSTRACT Not all women infected with chlamydiae develop upper genital tract disease, but the reason(s) for this remains undefined. Host genetics and hormonal changes associated menstrual cycle are possible explanations variable infection outcomes. It is also that disease severity depends on virulence of chlamydial inoculum. likely inoculum contains multiple genetic variants, differing in virulence. If virulent variants dominate, then individual more to severe disease. Based our previous...
Coumadin (rac-warfarin) is the most commonly used anticoagulant in world; however, its clinical use often challenging because of narrow therapeutic range and interindividual variations response. A critical contributor to uncertainty variability warfarin metabolism, which includes mostly oxidative but also reductive pathways. Reduction each enantiomer yields two alcohol isomers, corresponding four alcohols retain varying levels activity. Studies on kinetics reduction have lacked resolution...
Abstract— We sampled 130 individuals (2 to 25 per taxon) of Pinus subsections Ponderosae and Sabinianae . Nucleotide sequences were obtained by targeting 703 low copy nuclear genes. From the unenriched portion short reads, we assembled nearly complete plastome nucleotide sequences. used 600 genes create phylogenies species trees that compared evaluate cytonuclear concordance reticulation. found jeffreyi belongs with subsect. based on morphological synapomorphies as well strong molecular...
: For this pilot study, we leveraged metabolite patterns for warfarin patients to more accurately assess clinically relevant differences in drug metabolism. We tested our hypothesis that plasma levels correlate with the influence of clinical factors on R-warfarin and S-warfarin metabolism (warfarin metabolic phenotype). recruited 29 receiving a maintenance dose testing within targeted therapeutic range. determined their CYP2C9 vitamin K epoxide reductase genotype profiled 14 isomeric forms...
In 2020, nearly one-third of new drugs on the global market were synthetic cannabinoids including drug abuse N-(1-adamantyl)-1-(5-pentyl)-1H-indazole-3-carboxamide (5F-APINACA, 5F-AKB48). Knowledge 5F-APINACA metabolism provides a critical mechanistic basis to interpret and predict abuser outcomes. Prior qualitative studies identified which metabolic processes occur but not order extent them often relied problematic “semi-quantitative” mass spectroscopic (MS) approaches. We capitalized...
Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual variations response risks over or under dosing resulting adverse bleeding events ineffective therapy, respectively. Levels pharmacologically active forms drug and metabolites depend on a diversity metabolic pathways. Cytochromes P450 play major role oxidizing R- S-warfarin to 6-, 7-, 8-, 10-, 4′-hydroxywarfarin, warfarin alcohols form through...
Coumadin (R/S‐warfarin) anticoagulation therapy remains challenging due to a narrow therapeutic range and high inter‐individual variations in response. We hypothesize that plasma metabolite profiles capture clinically relevant warfarin metabolism as resource improve strategies minimize risk. profiled R‐ S‐warfarin ten oxidized metabolites from fifty‐nine patient samples using novel LC‐MS method. Profiles included S‐6‐, 7‐, 4′‐hydroxywarfarin plus four 10‐hydroxywarfarin diastereomers, yet...
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor and has a median survival time of 12 months, due in large part to poor responses chemo‐ radio‐therapy. These tumors exhibit high levels DNA damage response activation before treatment this likely plays role inherent radio‐resistance GBM. Y‐family polymerases aid cells bypassing genotoxic damage, but they are mis‐regulated many cancers. Over‐expression enzyme human polymerase kappa (hpol κ), which up‐regulated GBM...