A5067941155- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Neuroendocrine regulation and behavior
- Advanced NMR Techniques and Applications
- Health, Environment, Cognitive Aging
- Tryptophan and brain disorders
- Health disparities and outcomes
- Neonatal and fetal brain pathology
- Resilience and Mental Health
- Advanced Biosensing Techniques and Applications
- Early Childhood Education and Development
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Educational and Psychological Assessments
- Advanced MRI Techniques and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Fetal and Pediatric Neurological Disorders
- Advanced Fluorescence Microscopy Techniques
- Migration, Health and Trauma
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury Research
- Neuroscience of respiration and sleep
Yale University
2019-2025
Stanford University
2019-2020
Adversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account part this association. In sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N = 4006), we tested longitudinal structural equation model to examine indirect effect adversity (negative life events) on later psychopathology via changes resting-state functional (rsFC)....
Adolescence is characterized by rapid brain development in white matter (WM) that attributed part to surges gonadal hormones. To date, however, there have been few longitudinal investigations relating changes hormones and WM adolescents. We acquired diffusion-weighted MRI estimate mean fractional anisotropy (FA) from 10 tracts salivary testosterone 51 females 29 males (ages 9-14 years) who were matched on pubertal stage followed, average, for 2 years. tested whether interactions between sex...
Abstract Early life stress (ELS) is a risk factor for the development of depression in adolescence; mediating neurobiological mechanisms, however, are unknown. In this study, we examined early pubertal youth associations among ELS, cortisol responsivity, and white matter microstructure uncinate fasciculus fornix, two key frontolimbic tracts; also tested whether how these variables predicted depressive symptoms later puberty. A total 208 participants (117 females; M age = 11.37 years; Tanner...
Childhood experiences play a profound role in conferring risk and resilience for brain behavioral development. However, how different facets of the environment shape neurodevelopment remains largely unknown. Here we sought to decompose heterogeneous relationships between environmental factors structure 989 school-aged children from Adolescent Brain Cognitive Development Study. We applied cross-modal integration clustering approach called 'Similarity Network Fusion', which combined two...
Adolescence is marked by heightened stress exposure and psychopathology, but also vast potential for opportunity. We highlight how researchers can leverage both developmental individual differences in responding corticolimbic circuitry to optimize interventions during this unique period.
Abstract Exposure to socioeconomic disadvantages (SED) can have negative impacts on mental health, yet SED are a multifaceted construct and the precise processes by which confer deleterious effects less clear. Using large diverse sample of preadolescents (ages 9–10 years at baseline, n = 4038, 49% female) from Adolescent Brain Cognitive Development Study, we examined associations among both household (i.e., income–needs material hardship) neighborhood area deprivation unsafety) levels,...
Parsing heterogeneity in the nature of adversity exposure and neurobiological functioning may facilitate better understanding how shapes individual variation risk for resilience against anxiety. One putative mechanism linking with anxiety is disrupted threat safety learning. Here, we applied a person-centered approach (latent profile analysis) to characterize patterns at specific developmental stages threat/safety discrimination corticolimbic circuitry 120 young adults. We then compared...
Abstract Key theoretical frameworks have proposed that examining the impact of exposure to specific dimensions stress at developmental periods is likely yield important insight into processes risk and resilience. Utilizing a sample N = 549 young adults who provided detailed retrospective history their lifetime numerous traumatic ratings current trauma-related symptomatology via completion an online survey, here we test whether individual’s perception as either controllable or predictable...
Abstract The endocannabinoid system is an important regulator of emotional responses such as fear, and a number studies have implicated signaling in anxiety. fatty acid amide hydrolase (FAAH) C385A polymorphism, which associated with enhanced the brain, has been identified across species potential protective factor from In particular, adults variant FAAH 385A allele greater fronto‐amygdala connectivity lower anxiety symptoms. Whether broader network‐level differences exist, when during...
Neighborhood or area-level socioeconomic disadvantage is associated with neural alterations across the lifespan. Few studies, however, have examined effects of neighborhood on white matter microstructure during adolescence, an important period development that coincides increased risk for psychopathology. In 200 adolescents (ages 13-20 years; 54.5% female, 4% non-binary) recruited from two studies enriched early adversity and depression, we whether derived census tract data was related to in...
Abstract Infancy is marked by rapid neural and emotional development. The relation between brain function emotion in infancy, however, not well understood. Methods for measuring predominantly rely on the BOLD signal; interpretation of signal infancy challenging because neuronal‐hemodynamic immature. Regional cerebral blood flow (rCBF) provides a context infant can yield insight into developmental maturity regions that may support affective behaviors. This study aims to elucidate relations...
This article provides an overview of the study protocol for Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal in which we plan to recruit 60 depressed adolescents (ages 13-18 years) and 30 psychiatrically healthy controls order examine inflammatory glutamatergic pathways that contribute recurrence depression adolescents. TIGER is first effects peripheral inflammation on neurodevelopmental trajectories by assessing changes cortical glutamate Here, describe...
The motivation to approach or avoid incentives can change during adolescence. Advances in neuroimaging allow researchers characterize specific brain circuits that underlie these developmental changes. Whereas activity the nucleus accumbens (NAcc) predict toward incentive gain, anterior insula (AIns) is associated with avoidance of loss. Recent research characterized structural white-matter tract connecting two regions, but has neither been adolescence nor linked functional anticipation. In...
Abstract Early-life adversity is pervasive worldwide and represents a potent risk factor for increased mental health burden across the lifespan. However, there substantial individual heterogeneity in associations between exposure, neurobiological changes, problems. Accounting key features of such as developmental timing exposure may clarify adversity, neurodevelopment, health. The present study leverages sparse canonical correlation analysis to characterize modes covariation age integrity...
Abstract Adolescence, the transition between childhood and adulthood, is characterized by rapid brain development in white matter (WM) that attributed part to surges gonadal hormones. To date, however, there have been no longitudinal investigations of effects hormones on WM adolescents. We acquired T1-weighted diffusion-weighted MRIs at two timepoints saliva samples from 80 adolescents (52 females [11.10±1.05 years Time 1; 12.75±1.37 2] 28 males [ages 11.91±0.88 13.79±0.95 who were matched...