A5103077690- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Infant Development and Preterm Care
- Neural dynamics and brain function
- Birth, Development, and Health
- Anesthesia and Neurotoxicity Research
- Early Childhood Education and Development
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Child Abuse and Trauma
- Face Recognition and Perception
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Cognitive Abilities and Testing
- Heart Rate Variability and Autonomic Control
- Infant Health and Development
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
Washington University in St. Louis
2019-2025
University of Pennsylvania
2021
Virginia Tech
2021
University of Glasgow
2021
University of Pittsburgh
2018-2019
Stanford University
2016-2018
Center for the Neural Basis of Cognition
2018
Palo Alto University
2017
Exposure to stress has been causally linked changes in hippocampal volume (HV). Given that the hippocampus undergoes rapid first years of life, stressful experiences during this period may be particularly important understanding individual differences development hippocampus. One hundred seventy-eight early adolescents (ages 9-13 years; 43% male) were interviewed regarding exposure and age onset stress; severity each event was rated by an objective panel. All participants underwent...
Abstract Numerous studies have linked exposure to stress adverse health outcomes through the effects of cortisol, a product response system, on cellular aging processes. Accelerated DNA methylation age is promising epigenetic marker associated with and disease risk that may constitute link from changes in neural structures. Specifically, elevated glucocorticoid signaling likely contributes accelerating age, which signify maladaptive stress-related cascade leads hippocampal atrophy. We...
<h3>Importance</h3> Adolescence is a neurodevelopmental period during which experience-dependent plasticity in brain circuitry may confer vulnerability to depression as well resilience disorder. Little known, however, about the neural mechanisms that underlie this critical of development. <h3>Objective</h3> To examine functional connectivity correlates adolescent females at high and low familial risk for who did not develop <h3>Design, Setting, Participants</h3> A longitudinal study was...
Research to date has largely conceptualized irritability in terms of intraindividual differences. However, the role interpersonal dyadic processes received little consideration. Nevertheless, difficulties how parent-child dyads synchronize during interactions may be an important correlate irritably early childhood. Innovations developmentally sensitive neuroimaging methods now enable use measures neural synchrony quantify synchronous responses and can help clarify underpinnings these...
Stressful experiences are linked to neurodevelopment. There is growing interest in the role of stress connectivity between amygdala and medial prefrontal cortex (mPFC), a circuit that subserves automatic emotion regulation. However, specific timing mechanisms underlie association amygdala–mPFC unclear. Many factors, including variations fetal exposure maternal stress, appear affect early developing brain circuitry. few studies have examined associations life, when most plastic sensitive...
The cerebral cortex is organized into distinct but interconnected cortical areas, which can be defined by abrupt differences in patterns of resting state functional connectivity (FC) across the surface. Such parcellations have been derived adults and older infants, there no widely used surface parcellation available for neonatal brain. Here, we first demonstrate that existing parcellations, including surface-based parcels from samples as well volume-based parcels, are a poor fit data. We...
<h3>Background:</h3> Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The also associated with abnormal neural reward circuitry, particularly the basal ganglia (BG). Here we assessed BG volume both patients MDD and healthy control participants. <h3>Methods:</h3> We obtained whole-brain <i>T</i><sub>1</sub>-weighted images from controls. estimated grey matter...
Children from lower-SES families exhibit smaller hippocampal volume than do their higher-SES peers. Few studies, however, have compared developmental trajectories as a function of SES. Thus, it is unclear whether initial rank-order stability preserved, or volumes diverge/converge over the course adolescence. In sample 101 girls ages 10-24 years, we examined longitudinal association between family income and parental education, proxies for SES, changes in volume. Hippocampal was obtained...
Abstract Major depressive disorder (MDD) is characterized by the altered integration of reward histories and reduced responding striatum. We have posited that this striatal activation in MDD due to tonically decreased stimulation dopamine synapses which results decremented propagation information along cortico-striatal-pallido-thalamic (CSPT) spiral. In present investigation, we tested predictions formulation conducting concurrent functional magnetic resonance imaging (fMRI) 11 C-raclopride...
The quantity and quality of the language input that infants receive from their caregivers affects future abilities; however, it is unclear how variation in this relates to preverbal brain circuitry. current study investigated relation between naturalistic functional connectivity (FC) networks human infancy using resting-state magnetic resonance imaging (rsfMRI). We recorded environments five- eight-month-old male female Linguistic ENvironment Analysis (LENA) system measured consistency...
Parent-child synchrony-parent-child interaction patterns characterized by contingent social responding, mutual responsivity, and co-regulation-has been robustly associated with adaptive child outcomes. Synchrony has investigated in both behavioral biological frameworks. While it demonstrated that adversity can influence parent-child synchrony, the neural mechanisms which this disruption occurs are understudied. The current study examined association between adversity, synchrony across...
The field of adult neuroimaging relies on well-established principles in research design, imaging sequences, processing pipelines, as well safety and data collection protocols. infant magnetic resonance imaging, by comparison, is a young with tremendous scientific potential but continuously evolving standards. present article aims to initiate constructive dialog between researchers who grapple the challenges inherent limitations nascent reviewers evaluate their work. We address 20 questions...
Abstract Researchers are becoming increasingly interested in linking specific forms of early life stress (ELS) to neurobiological markers, including alterations the morphology stress-sensitive brain regions. We used a person-centered, multi-informant approach investigate associations constellations ELS with hippocampal and amygdala volume community sample 211 9- 13-year-old adolescents. Further, we compared this cumulative risk model ELS, which was quantified by total number stressors...
Pregnancy is a period of profound biological transformation. However, we know remarkably little about pregnancy-related brain changes. To address this gap, chart longitudinal changes in structure during pregnancy and explore potential mechanisms driving these Ten participants (Mean age = 28.97 years) are assessed 1-6 times (median 3) their pregnancy. Each visit includes anatomical diffusion-weighted MRI, assessments waking salivary hormones, hair inflammatory cytokines. Here observe...
Suicidal ideation (SI), a potent risk factor for suicide attempts, increases in adolescence. While alterations dopaminergic functioning have been implicated suicidal acts—particularly adults—we do not know whether morphological dopamine-rich regions of the brain, such as striatum, are vulnerability factors emergence SI adolescents. At baseline, community sample 152 adolescents (89 female; mean age: 11.41 ± 1.01 years) completed magnetic resonance imaging (MRI) scan that was used to estimate...
Pregnancy is a period of profound biological transformation. However, we know remarkably little about pregnancy-related brain changes. To address this gap, chart longitudinal changes in structure during pregnancy and explore potential mechanisms driving these Ten participants (Mean age = 28.97 years) are assessed 1-6 times (median 3) their pregnancy. Each visit includes anatomical diffusion-weighted MRI, assessments waking salivary hormones, hair inflammatory cytokines. Here observe...
As scientists interested in fetal, infant, and toddler (FIT) neurodevelopment, our research questions often focus on how individual children differ their neurodevelopment the predictive value of those differences for long-term neural behavioral outcomes. Measuring interpreting can present challenges: Is there a "standard" way human brain to develop? How do semantic, practical, or theoretical constraints that we place studying "development" influence measure interpret differences? While it is...