A5037698851- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Oral Health Pathology and Treatment
- Experimental Learning in Engineering
- Mechatronics Education and Applications
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- PARP inhibition in cancer therapy
- Innovative Teaching Methods
Hungarian Academy of Sciences
2023
University of Debrecen
2019-2023
University of Szeged
2019
Abstract The existence of a gut‐skin axis is supported by increasing evidence, but its translational potential not widely recognized. Studies linked inflammatory skin diseases to an imbalanced gut microbiome; hence, the modulation microbiota improve condition seems be feasible approach. Today, there growing interest in natural products as alternatives synthetic drugs. In this respect, oral probiotics could simple, safe and cheap modality therapeutic management inflammation. Unfortunately,...
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players development lesions. APCs include dendritic cells, Langerhans and monocytes/macrophages. In addition, epidermal keratinocytes dermal mast also endowed with capacity. Skin have central role maintenance cutaneous immune homeostasis, well...
Poly(ADP-ribose) polymerase-1 (PARP1) is a pro-inflammatory protein, whose properties were demonstrated in human. The of PARP1 shown Th1- and Th2-mediated inflammatory pathologies, but not Th17-mediated inflammation. Thus, we studied the role imiquimod-induced model psoriasis. To our surprise, psoriasis, acted as an anti-inflammatory factor its genetic deletion exacerbated symptoms. We showed that absence PARP1, epidermis thickened number TUNEL-positive cells decreased epidermis. These data...
Poly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity, and they were first described as DNA repair factors. However, research in past decades implicated PARPs biological functions diverse regulation energetics, lipid homeostasis, cell death, inflammation. activation was Th2-mediated inflammatory processes, but studies focused on role PARP1, while we have little information PARP2 regulation. In this study, assessed a Th17-mediated skin...
More and more of today’s devices are electronic software operated. Since they measure the signals real world act as a result processing, informatics is getting closer to interdisciplinary fields. The technology everyday devices, automotive industry, Industry 4.0, Internet Things (IoT) based al-so on engineering, physics, electronics, biology other fields besides informatics. Accordingly, in-terdisciplinarity important in education too, it essential teach related solutions for teacher...
Abstract Poly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity and they were first described as DNA repair factors. However, research in past decades implicated PARPs biological functions diverse regulation energetics, lipid homeostasis, cell death inflammation. activation was Th2-mediated inflammatory processes, but studies focused on role PARP1, while we have little information PARP2 regulation. In this study assessed a Th17-mediated...