A5002364383- Advanced MRI Techniques and Applications
- Medical Image Segmentation Techniques
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Advanced Neuroimaging Techniques and Applications
- Elasticity and Material Modeling
- Hemodynamic Monitoring and Therapy
- Aortic aneurysm repair treatments
- Image and Object Detection Techniques
- Advanced X-ray and CT Imaging
- Ultrasound in Clinical Applications
- Medical Imaging Techniques and Applications
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Advanced Vision and Imaging
- Medical Imaging and Analysis
- Non-Invasive Vital Sign Monitoring
- Image and Signal Denoising Methods
- Ultrasound Imaging and Elastography
- Renal and Vascular Pathologies
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Mathematical Analysis and Transform Methods
Leiden University Medical Center
2004-2024
Eindhoven University of Technology
2009-2020
Signal Processing (United States)
2012-2018
Catharina Ziekenhuis
2016
Radboud University Nijmegen
2016
University of Florida
2005
Leiden University
2002-2003
We advocate the use of an alternative calculus in biomedical image analysis, known as multiplicative (a.k.a. non-Newtonian) calculus. It provides a natural framework problems which positive images or definite matrix fields and positivity preserving operators are interest. Indeed, its merit lies fact that preservation under basic but important operations, such differentiation, is manifest. In case scalar functions, general any set functions with commutative codomain, it convenient, albeit...
Identification of flow patterns within the heart has long been recognized as a potential contribution to understanding physiological and pathophysiological processes cardiovascular diseases. Although pulsatile itself is multi-dimensional multi-directional, current available non-invasive imaging modalities in clinical practice provide calculation only 1-direction lack 3-dimensional volumetric velocity information. Four-dimensional magnetic resonance (4D CMR) emerged novel tool that enables...
This study explores the relationship between in vivo 4D flow cardiovascular magnetic resonance (CMR) derived blood energetics total cavopulmonary connection (TCPC), exercise capacity and CMR-derived liver fibrosis/congestion. The Fontan circulation, which both caval veins are directly connected with pulmonary arteries (i.e. TCPC) is palliative approach for single ventricle patients. Blood efficiency TCPC has been associated fibrosis using computational fluid dynamic modelling. CMR allows...
Manual quantitative analysis of cardiac left ventricular function using multislice CT and MR is arduous because the large data volume. In this paper, we present a 3-D active shape model (ASM) for semiautomatic segmentation volumes, without requirement retraining underlying statistical model. A fuzzy c-means based inference system was incorporated into Thus, relative gray-level differences instead absolute gray values were used classification regions interest (ROIs), removing necessity...
Load-bearing soft tissues predominantly consist of collagen and exhibit anisotropic, non-linear visco-elastic behavior, coupled to the organization fibers. Mimicking native mechanical behavior forms a major goal in cardiovascular tissue engineering. Engineered often lack properly organized consequently do not meet vivo demands. To improve architecture properties, stimulation during vitro growth is crucial. This study describes evolution fiber orientation with culture time engineered...
A widely used subpixel precision estimate of an object center is the weighted gravity (COG). We derive three maximum-likelihood estimators for variance two-dimensional (2-D) COG as a function noise in image. assume that additive, Gaussian distributed and independent between neighboring pixels. Repeated experiments using 2500 generated 2-D bell-shaped markers superimposed with increasing amount were performed, to compare approximations. The error most exact approximative respect true was...
Skeletal muscle tissue engineering has major promise for regenerative treatment of patients suffering from loss due to, example, traumatic injury, but faces considerable challenges to progress toward clinical application. In the present study creation an aligned prevascularized was addressed. We hypothesized that vascularized three-dimensional (3D) can be induced in vitro by merely using uniaxial stress. The showed not only do endothelial cells and independently align direction stress a...
Hemodynamic aorta parameters can be derived from 4D flow MRI, but this requires lumen segmentation. In both commercially available and research MRI software tools, segmentation is mostly (semi-)automatically performed subsequently manually improved by an observer. Since the variability, together with data image processing algorithms, will contribute to reproducibility of patient-specific properties, observer's repeatability needs assessed.To determine interexamination, interobserver...
In this paper a contour detection method is described and evaluated on the evaluation data sets of Cardiac MR Left Ventricle Segmentation Challenge as part MICCAI 2009’s 3D for Clinical Applications. The proposed method, using 2D AAM ASM, performs fully automated myocardial contours, not requiring any user interaction. algorithm’s performance reported metrics provided by LV organization. Endocardial was classified successful in 86% images epicardial contours 94%. average perpendicular...
Background Left ventricular (LV) and right (RV) function have an important impact on symptom occurrence, disease progression exercise tolerance in pressure overload-induced heart failure, but particularly RV functional changes are not well described the relevant aortic banding mouse model. Therefore, we quantified time-dependent alterations morphology two models of hypertrophy failure studied relationship between LV during transition from to failure. Methods MRI was used quantify healthy (n...
The aim of this study is to investigate the inter and intra-rater reliability, repeatability, reproducibility pulmonary transit time (PTT) measurement in patients using contrast enhanced ultrasound (CEUS), as an indirect measure preload left ventricular function.Mean times (MTT) were measured by drawing a region interest (ROI) right cardiac ventricle CEUS loops. Acoustic intensity dilution curves obtained from ROIs. MTTs calculated applying model-based fitting on curves. PTT was difference...
Degenerative thoracic aortic aneurysm (TAA) patients are known to be at risk of life-threatening acute events. Guidelines recommend preemptive surgery diameters greater than 55 mm, although many with small aneurysms show only mild growth rates and more half complications occur in below this threshold. Thus, assessment hemodynamics using 4-dimensional flow magnetic resonance has been interest obtain insights development. Nonetheless, the role aberrant patterns TAA is not yet fully...
Contrast-enhanced ultrasound (CEUS) has recently been proposed as a minimally- invasive, alternative method for blood volume measurement. This study aims at comparing the accuracy of CEUS and classical thermodilution techniques assessment in an in-vitro set-up. The set-up consisted variable network between inflow outflow tube roller pump. tubes were insonified with array transducer thermistor was placed each tube. Indicator dilution curves made by injecting indicator which...
To study flow-related energetics in multiple anatomical segments of the total cavopulmonary connection (TCPC) Fontan patients from four-dimensional (4D) flow magnetic resonance imaging (MRI), and to relationship between adverse patterns segment-specific energetics.Twenty-six extracardiac underwent 4D MRI TCPC. A segmentation TCPC was automatically divided into five [conduit, superior vena cava (SVC), right/left pulmonary artery (LPA), confluence]. The presence vortical arteries or confluence...
Abstract Background: Pulmonary transit time (PTT) is an indirect measure of preload and left ventricular function, which can be estimated using the indicator dilution theory by contrast-enhanced ultrasound (CEUS). In this study, we first assessed accuracy PTT-CEUS comparing it with dynamic magnetic resonance imaging (DCE-MRI). Secondly, tested hypothesis that correlates severity heart failure, MRI N-terminal pro-B-type natriuretic peptide (NT-proBNP). Methods results: Twenty patients...