A5049452068- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Medical Image Segmentation Techniques
- Coronary Artery Anomalies
- MRI in cancer diagnosis
- Elasticity and Material Modeling
- Atomic and Subatomic Physics Research
- Renal and Vascular Pathologies
- Vascular anomalies and interventions
- Diabetes Treatment and Management
- Coronary Interventions and Diagnostics
- Medical Imaging Techniques and Applications
- Medical Imaging and Analysis
Leiden University Medical Center
2016-2025
Federico II University Hospital
2025
Leiden University
2012-2023
Erasmus University Rotterdam
2022
Erasmus MC
2022
University Medical Center Utrecht
2020
Northwestern University
2019
Ramathibodi Hospital
2018
Philips (United Kingdom)
2017
Norwood Hospital
2017
The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, study purpose was to evaluate predictive value assessed with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate in patients previous myocardial infarction.Ninety-one (age, 65+/-11 years) infarction scheduled for ICD implantation underwent cine left function volumes characterization scar...
Abstract Purpose To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWV MRI ) with PWV determined from invasive intra‐aortic pressure measurements INV and to test the reproducibility measurement by MRI. Materials Methods was compared in 18 nonconsecutive patients scheduled for catheterization suspected coronary artery disease. Reproducibility tested 10 healthy volunteers who underwent repeated at a single occasion. Velocity‐encoded performed on all...
To validate flow assessment performed with three-dimensional (3D) three-directional velocity-encoded (VE) magnetic resonance (MR) imaging retrospective valve tracking and to compare this modality conventional two-dimensional (2D) one-directional VE MR in healthy subjects patients regurgitation.Patients volunteers gave informed consent, local medical ethics committee approval was obtained. Patient data were selected retrospectively randomly from a database of studies obtained between July...
High reproducibility of LV mass and volume measurement from cine cardiovascular magnetic resonance (CMR) has been shown within single centers. However, the extent to which contours may vary center center, due different training protocols, is unknown. We aimed quantify sources variation between many centers, provide a multi-center consensus ground truth dataset for benchmarking automated processing tools facilitating new readers in CMR analysis. Seven independent expert readers, representing...
To validate 3-dimensional (3D) 3-directional velocity-encoded (VE) magnetic resonance imaging (MRI) for flow assessment through all 4 heart valves simultaneously with retrospective valve-tracking during off-line analysis in healthy volunteers and patients valvular regurgitation.Three-dimensional VE MRI was performed 22 29 ischemic cardiomyopathy who were suspected of regurgitation net volumes the compared. Furthermore, repeated each valve 10 regurgitant to assess intra- interobserver...
quantification of mitral regurgitation severity with 2-dimensional (2D) imaging techniques remains challenging. The present study compared the accuracy 2D transesophageal echocardiography (TEE) and 3-dimensional (3D) TEE for regurgitation, using MRI as reference method.two-dimensional 3D cardiac were performed in 30 patients regurgitation. Mitral effective regurgitant orifice area (EROA) volume (Rvol) estimated TEE. With TEE, EROA was calculated planimetry color Doppler flow from en face...
LV diastolic vortex formation has been suggested to critically contribute efficient blood pumping function, while altered associated with pathologies. Therefore, quantitative characterization of flow might provide a novel objective tool for evaluating function. The objectives this study were 1) assess feasibility analysis during both early and late filling in vivo normal subjects using 4D Flow cardiovascular magnetic resonance (CMR) retrospective cardiac gating 3D core 2) establish...
Abstract Background Liraglutide is an antidiabetic agent with cardioprotective effect. The purpose of this study to test efficacy liraglutide improve diabetic cardiomyopathy in patients diabetes mellitus type 2 (DM2) without cardiovascular disease. Methods Patients DM2 were randomly assigned receive 1.8 mg/day or placebo double-blind trial 26 weeks. Primary outcome measures LV diastolic function (early (E) and late (A) transmitral peak flow rate, E/A ratio, early deceleration (Edec), mitral...
Purpose To evaluate viscous energy loss and the association with three‐dimensional (3D) vortex ring formation in left ventricular (LV) blood flow during diastolic filling. Theory Methods Thirty healthy volunteers were compared 32 patients corrected atrioventricular septal defect as unnatural mitral valve morphology inflow are common these patients. 4DFlow MRI was acquired from which 3D identified LV at peak early (E)‐filling late (A)‐filling characterized by its presence/absence,...
Myocardial infarction (MI) leads to complex changes in left ventricular (LV) haemodynamics that are linked clinical outcomes. We hypothesize LV blood flow kinetic energy (KE) is altered MI and associated with function infarct characteristics. This study aimed investigate the intra-cavity KE controls patients, using cardiovascular magnetic resonance (CMR) four-dimensional (4D) assessment.
To assess the relative value of a novel measure left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and extent scar tissue for prediction response to cardiac resynchronization therapy (CRT).Thirty-five heart failure patients scheduled CRT were included. Left was defined as standard deviation 16 segment time-to-maximum radial wall thickness (SDt-16) obtained cine-set short-axis slices. Delayed-enhanced MRI performed analysis. Echocardiography used determine...
Background Accurate assessment of mechanical properties the proximal aorta is a requisite first step for elucidating pathophysiology isolated systolic hypertension. During systole, substantial aortic axial displacement produces longitudinal strain, which we hypothesize causes variable underestimation ascending circumferential strain compared to values in longitudinally constrained descending aorta. Methods and Results To assess effects performed magnetic resonance imaging 375 participants...
The main aim of this study was to characterize changes in the left ventricular (LV) blood flow kinetic energy (KE) using four-dimensional (4D) cardiovascular magnetic resonance imaging (CMR) patients with myocardial infarction (MI) with/without LV thrombus (LVT).