A5050027169- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Elasticity and Material Modeling
- Medical Image Segmentation Techniques
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiomyopathy and Myosin Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- 3D Shape Modeling and Analysis
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Medical Imaging and Analysis
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
University of Auckland
2016-2025
King's College London
2019-2025
St Thomas' Hospital
2021-2024
Leeds Teaching Hospitals NHS Trust
2022-2024
Auckland City Hospital
2008-2023
University of Michigan
2023
Linköping University
2023
Massachusetts Institute of Technology
2023
King's College School
2023
King's College Hospital
2023
This paper reviews state-of-the-art research solutions across the spectrum of medical imaging informatics, discusses clinical translation, and provides future directions for advancing practice. More specifically, it summarizes advances in acquisition technologies different modalities, highlighting necessity efficient data management strategies context AI big healthcare analytics. It then a synopsis contemporary emerging algorithmic methods disease classification organ/ tissue segmentation,...
BACKGROUND In hypertrophic cardiomyopathy, ejection fraction is normal or increased, and force-length relations are reduced. However, three-dimensional (3D) motion deformation in vivo have not been assessed this condition. We reconstructed the 3D of left ventricle (LV) during systole 7 patients with cardiomyopathy (HCM) 12 volunteers by use magnetic resonance tagging. METHODS AND RESULTS Transmural tagging stripes were automatically tracked to subpixel resolution an active contour model. A...
Background: UK Biobank's ambitious aim is to perform cardiovascular magnetic resonance (CMR) in 100,000 people previously recruited into this prospective cohort study of half a million 40-69 year-olds.Methods/design: We describe the CMR protocol applied pilot phase, which will be extended main phase with three centres using same equipment and protocols.The includes white blood (sagittal anatomy, coronary transverse anatomy), cine (long axis cines, short cines ventricles, coronal LVOT cine),...
Abstract Motivation: Integrative mathematical and statistical models of cardiac anatomy physiology can play a vital role in understanding disease phenotype planning therapeutic strategies. However, the accuracy predictive power such is dependent upon breadth depth noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established large-scale database examinations associated clinical data order to develop shareable, web-accessible, structural functional atlas normal pathological...
UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging received funding. Cardiovascular magnetic resonance (CMR) will be part of multi-organ, multi-modality visit in 3-4 dedicated centres that acquire and store data from 100,000 (subject successful piloting). In each Biobank's bespoke centres, it proposed 15-20 undergo 2 3 hour per day, seven days week over period 5-6 years. The modalities include brain MRI at Tesla, CMR abdominal 1.5...
We examined the shear properties of passive ventricular myocardium in six pig hearts. Samples (3 × 3 mm) were cut from adjacent regions lateral left midwall, with sides aligned principal material axes. Four cycles sinusoidal simple (maximum displacements 0.1–0.5) applied separately to each specimen two orthogonal directions. Resulting forces along three axes measured. Three specimens heart tested different orientations cover all modes deformation. Passive has nonlinear viscoelastic...
A method for in vivo estimation of the three-dimensional (3D) motion and deformation heart from tagged magnetic resonance images myocardium is presented. The based on a 3D deformable model fitted to points two views (short long axes), which results comprehensive kinematic dynamic geometry left ventricle. was applied data obtained four healthy volunteers, were pooled according position within model. Analytic modeling demonstrated that calculated strain field relatively invariant type...
Magnetic resonance tissue tagging allows noninvasive in vivo measurement of soft deformation. Planes magnetic saturation are created, orthogonal to the imaging plane, which form dark lines (stripes) image. The authors describe a method for tracking stripe motion image and show how this information can be incorporated into finite element model underlying Human heart data were acquired from several planes different orientations combined using deformable left ventricle wall. Each tracked point...
The authors describe a fast method for calculating left ventricle (LV) mass and volumes from multiplanar magnetic resonance (MR) images. Mathematic models were fitted to small number of user-selected guide points in 15 healthy volunteers, 13 patients after myocardial infarction, canine model mitral regurgitation eight dogs. Errors between manual contours (LV mass, 1.8 g ± 4.9 [mean SD]; end-diastolic volume, 2.2 mL 4.6; end-systolic 2.3 3.8). Estimates global function could be obtained 6...
BACKGROUND Myocardial tissue tagging with the use of magnetic resonance imaging allows noninvasive regional analysis heart wall motion and deformation. However, any evaluation effect disease or treatment requires a baseline reference normal values variation. We studied two-dimensional material points imaged within left ventricular using spatial modulation magnetization (SPAMM) in 12 human volunteers. METHODS AND RESULTS Five parallel short-axis five long-axis slices were acquired at times...
Myocardial tagging with magnetic resonance imaging is useful for non-invasive estimation of in vivo heart wall deformation. To validate the method strain and quantify error deformation estimates, a deformable silicone gel phantom shape cylindrical anulus was built imaged. Four observers digitized displacement tags two modes: axial shear, caused by 45 degrees rotation inner cylinder, azimuthal 13.5-mm longitudinal translation cylinder. In good agreement found between angular stripes painted...
High reproducibility of LV mass and volume measurement from cine cardiovascular magnetic resonance (CMR) has been shown within single centers. However, the extent to which contours may vary center center, due different training protocols, is unknown. We aimed quantify sources variation between many centers, provide a multi-center consensus ground truth dataset for benchmarking automated processing tools facilitating new readers in CMR analysis. Seven independent expert readers, representing...
Purpose Public private partnership (PPP), which has been operating in China for over 20 years. In addition, an increased focus on value money the public sector led to a need improve efficiency of management, delivery and effectiveness services, especially at local level. This paper aims examines PPP system problems yet be overcome time when is seeking widen use sectors as not open it. Design/methodology/approach The current identifies constraints facing it context several models bureaucracy...
With aging, structural and functional changes occur in the myocardium without obvious impairment of systolic left ventricular (LV) function. Transmural differences myocardial vulnerability for these may result increase transmural inhomogeneity contractile myofiber Subendocardial fibrosis subendocardial perfusion due to hypertension might change distribution The ratio LV torsion endocardial circumferential shortening (torsion-to-shortening ratio; TSR) during systole reflects We investigated...
Public health surveillance systems provide valuable data for reliable predication of future epidemic events. This paper describes a study that used nine types infectious disease collected through national public system in mainland China to evaluate and compare the performances four time series methods, namely, two decomposition methods (regression exponential smoothing), autoregressive integrated moving average (ARIMA) support vector machine (SVM). The obtained from 2005 2011 2012 were as...
Accurate incidence forecasting of infectious disease is critical for early prevention and better government strategic planning. In this paper, we present a comprehensive study different methods based on the monthly typhoid fever. The seasonal autoregressive integrated moving average (SARIMA) model three models inspired by neural networks, namely, back propagation networks (BPNN), radial basis function (RBFNN), Elman recurrent (ERNN) were compared. differences as well advantages...
4D-flow magnetic resonance imaging (MRI) is an emerging technique where spatiotemporal 3D blood velocity can be captured with full volumetric coverage in a single non-invasive examination. This enables qualitative and quantitative analysis of hemodynamic flow parameters the heart great vessels. An increase image resolution would provide more accuracy allow better assessment flow, especially for patients abnormal flows. However, this must balanced increasing time. The recent success deep...
Purpose To compare cardiovascular magnetic resonance‐feature tracking (CMR‐FT) with spatial modulation of magnetization (SPAMM) tagged imaging for the calculation short and long axis Lagrangian strain measures in systole diastole. Materials Methods Healthy controls ( n = 35) patients dilated cardiomyopathy 10) were identified prospectively underwent steady‐state free precession (SSFP) cine SPAMM using a gradient‐echo sequence. A timed offline analysis images acquired at identical horizontal...