A5079098596- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- Infective Endocarditis Diagnosis and Management
- Dialysis and Renal Disease Management
- Nuclear Structure and Function
- Cardiac Structural Anomalies and Repair
- Chronic Kidney Disease and Diabetes
- MRI in cancer diagnosis
- Congenital Heart Disease Studies
- Cardiovascular Health and Disease Prevention
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Genetic and Kidney Cyst Diseases
- Organ Transplantation Techniques and Outcomes
- Medical Imaging and Pathology Studies
Queen Elizabeth Hospital Birmingham
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2011-2025
University of Birmingham
2016-2025
Queen Elizabeth Hospital
2019-2024
Hutchison/MRC Research Centre
2024
MRC Cancer Unit
2023-2024
University of Cambridge
2023-2024
NIHR Surgical Reconstruction and Microbiology Research Centre
2013-2023
University Hospitals of North Midlands NHS Trust
2023
Queen Elizabeth University Hospital
2022
AimsMyocardial deformation is a key to clinical decision-making. Feature-tracking cardiovascular magnetic resonance (FT-CMR) provides quantification of motion and strain using standard steady-state in free-precession (SSFP) imaging, which part routine CMR left ventricular (LV) study protocol. An accepted definition normal range essential if this technique enter the arena.
Serum phosphate independently predicts cardiovascular mortality in the general population and CKD, even when levels are normal range. Associations between serum phosphate, arterial stiffness, left ventricular (LV) mass suggest a possible pathophysiological mechanism, potentially mediated by phosphaturic hormone fibroblast growth factor-23 (FGF-23). To what extent binder sevelamer modulates these effects is not well understood. In this single-center, randomized, double-blind,...
Background— The optimum timing of surgery in asymptomatic patients with chronic severe primary degenerative mitral regurgitation (MR) remains controversial, and further markers are needed to improve decision-making. There limited data that wall stress is increased MR may result ventricular fibrosis. We investigated the hypothesis volume overload a stimulus for myocardial fibrosis using T1-mapping cardiac MRI. Methods Results— A cross-sectional study 35 (age 60±14 years) moderate (mean...
Purpose To compare cardiovascular magnetic resonance‐feature tracking (CMR‐FT) with spatial modulation of magnetization (SPAMM) tagged imaging for the calculation short and long axis Lagrangian strain measures in systole diastole. Materials Methods Healthy controls ( n = 35) patients dilated cardiomyopathy 10) were identified prospectively underwent steady‐state free precession (SSFP) cine SPAMM using a gradient‐echo sequence. A timed offline analysis images acquired at identical horizontal...
There is a robust inverse graded association between glomerular filtration rate (GFR) and cardiovascular risk, but proof of causality lacking. Emerging data suggest living kidney donation may be associated with increased mortality although the mechanisms are unclear. We hypothesized that reduction in GFR donors left ventricular mass, impaired function, aortic stiffness. This was multicenter, parallel group, blinded end point study healthy controls (n=124), conducted from March 2011 to August...
Abnormalities in cardiac structure and function are common patients hospitalized with severe COVID-19 pneumonia who have evidence of myocardial injury based on elevated high-sensitivity troponin (HScTn).1Kim J. Volodarskiy A. Sultana R. Pollie M.P. Yum B. Nambiar L. et al.Prognostic utility right ventricular remodeling over conventional risk stratification COVID-19.J Am Coll Cardiol. 2020; 76: 1965-1977Crossref PubMed Scopus (79) Google Scholar Studies performing transthoracic...
The 6-minute walk test (6MWT) represents a comprehensive functional assessment that is commonly used in patients with heart failure; however, data are lacking transthyretin cardiac amyloidosis (ATTR-CA).
Lamin (LMNA) heart disease is a lethal form of dilated cardiomyopathy (DCM). The authors explored its cardiovascular magnetic resonance (CMR) phenotype to discover prognostically useful and subclinical biomarkers. This prospective multicenter study recruited 4 groups: LMNA carriers with left ventricular ejection fraction ≥55% (Lamin+EF), <50% (Lamin-EF), individuals DCM wild-type (DCMwt), healthy volunteers. Phantom-calibrated CMR comprising cines, late gadolinium enhancement,...
Myocardial deformation is a sensitive marker of sub-clinical myocardial dysfunction that carries independent prognostic significance across broad range cardiovascular diseases. It now possible to perform 3D feature tracking SSFP cines on cardiac magnetic resonance imaging (FT-CMR). This study provides reference ranges for FT-CMR and assesses its reproducibility compared 2D FT-CMR. One hundred healthy individuals with 10 men women in each 5 age deciles from 20 70 years, underwent left...
Abstract These guidelines form an update of the BSE guideline protocol for assessment restrictive cardiomyopathy (Knight et al. in Echo Res Prac, 2013). Since original recommendations were conceived 2013, there has been exponential rise diagnosis cardiac amyloidosis fuelled by increased clinician awareness, improvements cardiovascular imaging as well availability new and effective disease modifying therapies. The initial can be challenging is often not clear-cut on basis echocardiography,...
<h3>Objective</h3> To explore the relationship between serum phosphate, arterial stiffness and left ventricular mass (LVM) in patients with early-stage chronic kidney disease (CKD). <h3>Design</h3> A cross-sectional observational study. <h3>Setting</h3> Single centre. <h3>Patients</h3> 208 stage 2 to 4 non-diabetic CKD. <h3>Interventions</h3> Arterial was determined through measurement of aortic pulse wave velocity (PWV). Cardiac magnetic resonance used determine LVM. <h3>Main outcome...
BackgroundEpidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study sought to investigate relationship between findings on echocardiography, mortality, race in COVID-19 pneumonia.MethodsThis was a multicentre, retrospective, observational including 164 adults (aged 61 ± 13 years; 78% male; 36% BAME) hospitalized...
Hereditary transthyretin-mediated amyloidosis (hATTR) is challenging to diagnose early owing the heterogeneity of clinical presentation, which differs according TTR gene variant and its penetrance in each individual. The variants seen most frequently UK Ireland (T80A, V142I V50M) differ those commonly occurring other geographic locations warrant a specific consideration for diagnosis genetic testing. In addition, recent availability treatment this condition has reinforced need more...
Aims Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to transplantation (CT). Despite case series demonstrating comparable outcomes CT between non-amyloid cardiomyopathies, considered be contraindication some centers, partly due perceived risk of amyloid recurrence the allograft. We report long-term at two tertiary centers. Materials methods Results retrospectively evaluated across centers...
BackgroundReproducible and repeatable assessment of right heart function is vital for monitoring congenital acquired disease. There increasing evidence the additional value myocardial deformation (strain strain rate) in determining prognosis. This study aims to determine reproducibility analyses using cardiovascular magnetic resonance feature tracking (FT-CMR); establish normal ranges within an adult population.MethodsA cohort 100 healthy subjects containing 10 males females from each decade...