A5079332540- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Magnesium in Health and Disease
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Otitis Media and Relapsing Polychondritis
- Vaccine Coverage and Hesitancy
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis Viruses Studies and Epidemiology
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- COVID-19 Impact on Reproduction
- Atherosclerosis and Cardiovascular Diseases
- Diabetes and associated disorders
- Escherichia coli research studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 detection and testing
- Electrolyte and hormonal disorders
- Immunotherapy and Immune Responses
- Clostridium difficile and Clostridium perfringens research
- Immune responses and vaccinations
University of Birmingham
2012-2024
University Hospitals Birmingham NHS Foundation Trust
2022-2024
National Health Service
2022
Institute of Immunology
2021
Queen Elizabeth Hospital Birmingham
2013
Serum phosphate independently predicts cardiovascular mortality in the general population and CKD, even when levels are normal range. Associations between serum phosphate, arterial stiffness, left ventricular (LV) mass suggest a possible pathophysiological mechanism, potentially mediated by phosphaturic hormone fibroblast growth factor-23 (FGF-23). To what extent binder sevelamer modulates these effects is not well understood. In this single-center, randomized, double-blind,...
Background Patients with chronic kidney disease have an increased cardiovascular risk that is not fully explained by traditional factors but appears to be related arterial stiffness. Cytomegalovirus (CMV) infection associated although the mechanisms for this are unknown. We examined whether CMV seropositivity was stiffness in patients disease. Methodology and Principal Findings In 215 non-diabetic disease, determined using anti-CMV IgG ELISA. Pulse wave velocity measured aortic...
Summary Objective Patients with chronic kidney disease (CKD) have dysregulated cortisol metabolism secondary to changes in 11β‐hydroxysteroid dehydrogenase (11β‐HSD) enzymes. The determinants of this and its clinical implications are poorly defined. Methods We performed a cross‐sectional study characterize shifts relation renal function, inflammation glycaemic control. Systemic activation by 11β‐HSD was measured as the metabolite ratio (tetrahydrocortisol [THF]+5α‐tetrahydrocortisol...
Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral left ventricular mass patients with stage 3 non-diabetic a cross-sectional observational study. Methodology Principal Findings A total of 120 were recruited (54% male, mean age 55±14 years, glomerular filtration rate 50±13 ml/min/1.73 m2). Abdominal aortic was...
Abstract Background Patients with chronic kidney disease (CKD) are more prone to severe infection. Vaccination is a key strategy reduce this risk. Some studies suggest vaccine efficacy may be reduced in patients CKD, despite preserved maintenance of long-term responses some pathogens and vaccines. Here, we investigated immune 2 vaccines CKD identify predictors immunological responsiveness. Methods Individuals >65 years old, or without nondialysis (n = 36 29, respectively), were...
Background: B cell chronic lymphocytic leukaemia (CLL) is associated with immune suppression and patients are at increased clinical risk following SARS-CoV-2 infection. Covid-19 vaccines offer the potential for protection against severe infection but relatively little known regarding profile of antibody response first or second vaccination.Methods: We studied spike-specific responses and/or vaccination in 299 CLL compared healthy donors. 13 underwent a standard interval (3-week) vaccine...
Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients impaired responsiveness all antigens, even those first encountered before onset. To examine this we evaluated antibody against two childhood vaccine tetanus (TT) diphtheria toxoids (DT) common pathogens, cytomegalovirus (CMV) Salmonella enterica serovar Enteritidis (SEn) in independent cohorts consisting age-matched individuals without CKD. Sera...
Abstract Variants of SARS-CoV-2 may evade natural and vaccine induced immunity monoclonal antibody immunotherapeutics. There is an urgent need to know how well antibodies, by healthy Clinically Extremely Vulnerable (CEV) patients, will bind thus help reduce transmission severity infection from variants concern (VOC). This study determines the cross-reactive binding serum antibodies obtained prior 28 days after a third vaccination in three cohorts; health care worker cohort who received doses...
Background/Objectives: Generalised immune dysfunction in chronic kidney disease, especially patients requiring haemodialysis (HD), significantly enhances the risk of severe infections. Vaccine-induced immunity is typically reduced HD populations. The SARS-CoV-2 pandemic provided an opportunity to examine magnitude and functionality antibody responses a previously unencountered antigen—Spike (S)-glycoprotein—after vaccination with different vaccine platforms (viral vector (VV); mRNA (mRV))....