A5033943325- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Medical Coding and Health Information
- Cardiovascular Effects of Exercise
- Atomic and Subatomic Physics Research
- Pericarditis and Cardiac Tamponade
- Viral Infections and Immunology Research
- Healthcare cost, quality, practices
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- Radiation Dose and Imaging
- Cardiac and Coronary Surgery Techniques
- Adrenal and Paraganglionic Tumors
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Aortic Disease and Treatment Approaches
- Systemic Lupus Erythematosus Research
University of Leeds
2016-2024
Leeds Teaching Hospitals NHS Trust
2020-2024
University of Liverpool
2014-2021
Liverpool Heart and Chest Hospital
2015-2021
Philips (Spain)
2020
Aintree University Hospital
2014-2020
Aintree University Hospitals NHS Foundation Trust
2016-2020
Hollywood Private Hospital
1994
Myocardial infarction (MI) leads to complex changes in left ventricular (LV) haemodynamics that are linked clinical outcomes. We hypothesize LV blood flow kinetic energy (KE) is altered MI and associated with function infarct characteristics. This study aimed investigate the intra-cavity KE controls patients, using cardiovascular magnetic resonance (CMR) four-dimensional (4D) assessment.
Non-invasive assessment of myocardial ischaemia is a cornerstone the diagnosis coronary artery disease. Measurement blood flow (MBF) using positron emission tomography (PET) current reference standard for non-invasive quantification ischaemia. Dynamic perfusion cardiovascular magnetic resonance (CMR) offers an alternative to PET and recently developed method with automated inline mapping has shown good correlation MBF values between CMR PET. This study assessed repeatability by in healthy...
The main aim of this study was to characterize changes in the left ventricular (LV) blood flow kinetic energy (KE) using four-dimensional (4D) cardiovascular magnetic resonance imaging (CMR) patients with myocardial infarction (MI) with/without LV thrombus (LVT).
Two-dimensional (2D) methods of assessing mitral inflow velocities are pre-load dependent, limiting their reliability for evaluating diastolic function. Left ventricular (LV) blood flow kinetic energy (KE) derived from four-dimensional cardiovascular magnetic resonance imaging (4D CMR) may offer improvements. It remains unclear whether 4D LV KE parameters associated with physiological factors, such as age when compared to 2D velocities. Fifty-three healthy volunteers underwent standard CMR,...
Expansion of the myocardial extracellular volume (ECV) is a surrogate measure focal/diffuse fibrosis and an independent marker prognosis in chronic heart disease. Changes ECV may also occur after infarction, acutely because oedema convalescence as part ventricular remodelling. The objective this study was to investigate changes pattern distribution regional (normal, infarcted oedematous segments) global left (LV) using semi-automated methods early late reperfused ST-elevation infarction...
Background Cardiac diffusion tensor imaging (cDTI) allows for in vivo characterization of myocardial microstructure. In cDTI, mean diffusivity and fractional anisotropy (FA)—markers magnitude water molecules—are known to change after infarction. However, little is about regional changes helix angle (HA) secondary eigenvector (E2A), which reflects orientations laminar sheetlets, their association with long-term recovery left ventricular ejection fraction (LVEF). Purpose To assess serial cDTI...
Background: Athletic cardiac remodeling can occasionally be difficult to differentiate from pathological hypertrophy. Detraining is a commonly used diagnostic test identify physiological hypertrophy, which diagnosed if hypertrophy regresses. We aimed establish whether athletic assessed by cardiovascular magnetic resonance mediated changes in intracellular or extracellular compartments and this occurs 1 3 months of detraining. Methods: Twenty-eight athletes about embark on period forced...
Background Four‐dimensional‐flow cardiac MR (4DF‐MR) offers advantages in primary mitral regurgitation. The relationship between 4DF‐MR‐derived regurgitant volume (MR‐Rvol) and the post‐operative left ventricular (LV) reverse remodeling has not yet been established. Purpose To ascertain if MR‐Rvol correlates with LV Study Type Prospective, single‐center, two arm, interventional vs. nonintervention observational study. Population Forty‐four patients (male N = 30; median age 68 [59–75]) at...
Background: We tested the hypothesis that a single high sensitivity troponin at limits of detection (LOD HSTnT) (<5 ng/l) combined with presentation non-ischaemic electrocardiogram is superior to low-risk Global Registry Acute Coronary Events (GRACE) (<75), Thrombolysis in Myocardial Infarction (TIMI) (≤1) and History, ECG, Age, Risk factors Troponin (HEART) score (≤3) as an aid early, safe discharge for suspected acute coronary syndrome. Methods: In prospective cohort study, risk...
Background Late gadolinium enhancement (LGE) imaging was validated for diagnosis and quantification of myocardial infarction (MI). Despite good contrast between scar normal myocardium, blood pool can be limited. Dark LGE sequences attempt to overcome this issue. Purpose To evaluate T 1 rho (T ρ)‐prepared dark sequence compare nulled (BN) phase sensitive inversion recovery (PSIR) standard myocardium (MN) PSIR detection scar. Study Type Prospective. Population Thirty patients with prior MI....
Current echocardiographic data reporting the impact of concomitant mitral regurgitation (MR) on outcome in patients who undergo transcatheter aortic valve replacement (TAVR) are conflicting. Using cardiovascular magnetic resonance (CMR) imaging, this study aimed to assess MR severity cardiac reverse remodeling and patient outcome. 85 undergoing TAVR with CMR pre- 6 m post-TAVR were evaluated. The protocol included cines for left (LV) right ventricular (RV) volumes, flow assessment,...
Background Late gadolinium enhancement (LGE) imaging is well validated for the diagnosis and quantification of myocardial infarction (MI). 2D LGE involves multiple breath‐holds acquisition short‐axis slices to cover left ventricle (LV). 3D methods LV in a single breath‐hold; however, breath‐hold duration typically long with images susceptible motion artifacts. Purpose/Hypothesis To assess mDIXON pulse sequence image quality quantitation MI. Study Type Prospective. Population Ninety‐ two...
Objectives: We sought to determine the relationship between changes in natriuretic peptides and symptoms as a consequence of introducing beta-blocker therapy, patients with chronic heart failure (CHF) persistent atrial fibrillation (AF). Methods: In randomised, double-blind, placebo-controlled study involving 47 CHF AF (mean age 68 years 62% men), we analysed individual change (Δ) B-type peptide (BNP) level introduction carvedilol (titrated target dose 25 mg twice daily, group A) or placebo...
When feasible, guidelines recommend mitral valve repair (MVr) over replacement (MVR) to treat primary regurgitation (MR), based upon historic outcome studies and transthoracic echocardiography (TTE) reverse remodeling studies. Cardiovascular magnetic resonance (CMR) offers reference standard biventricular assessment with superior MR quantification compared TTE. Using serial CMR in patients, we aimed investigate cardiac residual post-MVr vs MVR chordal preservation. 83 patients ≥...
Exercise cardiovascular magnetic resonance (Ex-CMR) typically requires complex post-processing or transient exercise cessation, decreasing clinical utility. We aimed to demonstrate the feasibility of assessing biventricular volumes and great vessel flow during continuous in-scanner Ex-CMR, using vendor provided Compressed SENSE (C-SENSE) sequences commercial analysis software (Cvi42).12 healthy volunteers (8-male, age: 35 ± 9 years) underwent supine cycle ergometer (Lode-BV) Ex-CMR (1.5T...
Cardiovascular magnetic resonance (CMR) image acquisition techniques during exercise typically requires either transient cessation of or complex post-processing, potentially compromising clinical utility. We evaluated the feasibility and reproducibility a navigated method for ventricular volumes assessment continuous physical exercise.Ten healthy volunteers underwent supine cycle ergometer (Lode) CMR on two separate occasions using free-breathing, multi-shot, navigated, balanced steady-state...
Background: Long-term right ventricular (RV) pacing leads to heart failure or a decline in left (LV) function up fifth of patients. We aimed establish whether patients with focal fibrosis detected on late gadolinium enhancement cardiovascular magnetic resonance (CMR) have deterioration LV after RV pacing. Methods: recruited 84 ejection fraction ≥40% into 2 observational CMR studies. Patients (n=34) dual-chamber device and preserved atrioventricular conduction underwent asynchronous modes...
Objectives Early access to invasive coronary angiography and revascularisation for high-risk non-ST elevation myocardial infarction (NSTEMI) improves outcomes is supported by current guidelines. We sought determine the most effective criteria at presentation emergency department (ED) identify NSTEMI. Setting Secondary care centre northwest England with national follow-up. Participants 1642 consecutive patients (median age 59, 52% male) presenting ED a primary symptom of chest pain in whom...
In cardiac magnetic resonance imaging, hyperenhancement of the pericardium post gadolinium administration in acute chest pain often signifies pericarditis with an inflammatory response and neovascularization. context constrictive pericarditis, case series have indicated that intensity thickness imply reversibility physiology pericarditis. We present a intense marked thickening patient antecedent pain. Surgical resection microscopy revealed chronic fibrotic state no evidence inflammation or...