A5090975321- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Pediatric Urology and Nephrology Studies
- Intracranial Aneurysms: Treatment and Complications
- Gastric Cancer Management and Outcomes
- Acute Myocardial Infarction Research
- Kidney Stones and Urolithiasis Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- MRI in cancer diagnosis
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Ultrasound in Clinical Applications
- Lung Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Renal and related cancers
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Medical Imaging Techniques and Applications
- Peripheral Artery Disease Management
University of Leeds
2019-2024
Cancer Research UK
2024
Leeds Teaching Hospitals NHS Trust
2020-2022
University of Basel
2018
Columbia University
2007-2017
New York Hospital Queens
2012-2017
Columbia University Irving Medical Center
2011-2017
NewYork–Presbyterian Hospital
2012-2017
Cardiovascular Research Foundation
2012-2017
University Hospital of Basel
2014-2015
<b>Objective</b> To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events patients with diabetes mellitus asymptomatic peripheral arterial disease. <b>Design</b> Multicentre, randomised, double blind, 2×2 factorial, controlled trial. <b>Setting</b> 16 hospital centres Scotland, supported by 188 primary care groups. <b>Participants</b> 1276 adults aged 40 type 1 2 an ankle brachial pressure...
Copeptin is a stable surrogate marker of vasopressin release; the peptides are stoichiometrically secreted from neurohypophysis due to elevated plasma osmolality or nonosmotic stress. We hypothesized that following stress pituitary surgery, patients with neurohypophyseal damage and eventual diabetes insipidus (DI) would not exhibit expected pronounced copeptin elevation.The objective was evaluate copeptin's accuracy predict DI surgery.This prospective multicenter observational cohort...
Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) is predictive of clinical decline, however underlying mechanisms remain unclear. Cardiac diffusion tensor imaging (cDTI) allows vivo characterization myocardial microstructure by quantifying mean diffusivity (MD), fractional anisotropy (FA) diffusion, and secondary eigenvector angle (E2A). In this cardiac magnetic resonance (CMR) study, we examine associations between perfusion cDTI parameters to understand the sequence...
Accurate 3D modelling of cardiac chambers is essential for clinical assessment volume and function, including structural, motion analysis. Furthermore, to study the correlation between morphology other patient information within a large population, it necessary automatically generate mesh models each subject population. In this study, we introduce MCSI-Net (Multi-Cue Shape Inference Network), where embed statistical shape model inside convolutional neural network leverage both phenotypic...
Background Cardiac diffusion tensor imaging (cDTI) allows for in vivo characterization of myocardial microstructure. In cDTI, mean diffusivity and fractional anisotropy (FA)—markers magnitude water molecules—are known to change after infarction. However, little is about regional changes helix angle (HA) secondary eigenvector (E2A), which reflects orientations laminar sheetlets, their association with long-term recovery left ventricular ejection fraction (LVEF). Purpose To assess serial cDTI...
Motion is a major confound in diffusion‐weighted imaging (DWI) the body, and it common cause of image artefacts. The effects are particularly severe cardiac applications, due to nonrigid cyclical deformation myocardium. Spin echo‐based DWI commonly employs gradient moment‐nulling techniques desensitise acquisition velocity acceleration, ie, nulling moments up 2nd order (M2‐nulled). However, current M2‐nulled scans limited encode diffusion along single direction at time. We propose method for...
Adverse LV remodeling post–ST-segment elevation myocardial infarction (STEMI) is associated with a poor prognosis, but the underlying mechanisms are not fully understood. Diffusion tensor (DT)-cardiac magnetic resonance (CMR) allows in vivo characterization of architecture and provides unique mechanistic insight into pathophysiologic changes following infarction. This study evaluated potential associations between DT-CMR performed soon after STEMI long-term adverse left ventricular (LV)...
BackgroundMedia depictions of violence, although often claimed to induce viewer aggression, have not been shown affect the cortical networks that regulate behavior.Methodology/Principal FindingsUsing functional magnetic resonance imaging (fMRI), we found repeated exposure violent media, but other equally arousing led both diminished response in right lateral orbitofrontal cortex (right ltOFC) and a decrease ltOFC-amygdala interaction. Reduced function this network has previously associated...
Cardiac diffusion tensor imaging (cDTI) using cardiovascular magnetic resonance (CMR) is a novel technique for the non-invasive assessment of myocardial microstructure. Previous studies have shown infarction to result in loss sheetlet angularity, derived by reduced secondary eigenvector (E2A) and reduction subendocardial cardiomyocytes, evidenced myocytes with right-handed orientation (RHM) on helix angle (HA) maps. Myocardial strain assessed feature tracking-CMR (FT-CMR) sensitive marker...
Excessively increased peripheral vasoconstriction is a hallmark of heart failure (HF). Here, we show that in mice with systolic HF post–myocardial infarction, the myogenic tone third-order mesenteric resistance vessels increased, vascular smooth muscle (VSM) membrane potential depolarized by ~20 mV, and vessel wall intracellular [Ca2+] elevated relative to sham-operated control mice. Despite [Ca2+], frequency amplitude spontaneous transient outward currents (STOCs), mediated large...
Observational studies have shown that dressings containing chlorhexidine gluconate (CHX) lower the incidence external ventricular drain (EVD)-associated infections (EVDAIs). This prospective, randomized controlled trial (RCT) efficacy of CHX-containing in reducing bacterial colonization.In this RCT, patients aged ≥18 years undergoing emergency EVD placement were randomly given either a or an otherwise identical control dressing at skin exit wound. The primary end-point was regrowth cultured...
Background The posterior communicating artery (PComA) is among the most common intracranial aneurysm locations, but flow diverter (FD) treatment with widely used pipeline embolization device (PED) remains an off-label that not well understood. PComA diversion complicated by presence of fetal circulation (FPC), which has estimated prevalence 4–29% and more in people black (11.5%) than white (4.9%) race. We present FD-PComA in-silico trial (IST) into FD performance aneurysms. ISTs use...
This video demonstrates noninvasive positive-pressure ventilation. In certain conditions, this technique offers the benefits of invasive ventilation with fewer risks that are associated intubation.
How prevalent is spontaneous thrombosis in a population containing all sizes of intracranial aneurysms? can we calibrate computational models based on published data? does differ normo- and hypertensive subjects? We address the first question through thorough analysis datasets that provide rates across different aneurysm characteristics. This provides data for subgroup general aneurysms, namely, those large giant size (>10 mm). Based these observed rates, our modeling platform enables silico...
To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous biopsy.Biopsies were performed facilitated ultrasound targeting (FUT) technology, incorporates a needle guide and onscreen beam-steered technology to permit highly precise deployment. Patient tumour characteristics, procedure time, complications biopsy efficacy documented. Wong-Baker pain levels obtained before, during 1 h after the procedure.Seven patients...
Background Intramyocardial hemorrhage (IMH) following ST‐elevation myocardial infarction (STEMI) is associated with poor prognosis. In cardiac magnetic resonance (MR), T2* mapping the reference standard for detecting IMH while diffusion tensor imaging (cDTI) can characterize architecture via fractional anisotropy (FA) and mean diffusivity (MD) of water molecules. The value cDTI in detection not currently known. Hypothesis detect post‐STEMI. Study Type Prospective. Subjects A total 50...
Abstract Percutaneous nephrolithotomy is now the gold standard for treatment of large renal stones. In this article, we describe indications use antegrade flexible nephroscopy during percutaneous nephrolithotomy, as well infundibular stenosis. We also discuss various new technologies to help in these endeavors, including digital cystoscopes and ureteroscopes our preferred baskets, particular techniques improving stone-free rates. The stenosis through access reviewed.
Background— We sought to determine inter-rater reliability of the 2009 Appropriate Use Criteria for radionuclide imaging and whether physicians at various levels training can effectively identify nuclear stress tests with inappropriate indications. Methods Results— Four hundred patients were randomly selected from a consecutive cohort undergoing testing an academic medical center. Raters different (including cardiology attending physicians, fellows, internal medicine hospitalists, interns)...