A5101433175- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Chemokine receptors and signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Renal function and acid-base balance
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Pharmacy and Medical Practices
- Healthcare and Venom Research
- Erythrocyte Function and Pathophysiology
- Respiratory Support and Mechanisms
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- Kidney Stones and Urolithiasis Treatments
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
Guiyang Medical University
2023-2025
Affiliated Hospital of Guizhou Medical University
2023-2025
The First Hospital of Changsha
2021
Sun Yat-sen University Cancer Center
2005-2020
Sun Yat-sen University
2001-2020
State Key Laboratory of Oncology in South China
2013-2019
Creative Commons
2016
Christie's
2016
Objective: To investigate the role of programmed death-1 (PD-1), death-ligand 1 (PD-L1), and P16 in patients with head neck squamous cell carcinoma (HNSCC). Methods: A total 95 paraffin-embedded samples tumorous tissue HNSCC were collected. Expression levels PD-1, PD-L1, determined by immunohistochemistry. Results: significantly higher proportion PD-1 among infected human papillomavirus was found. PD-L1 expression is closely associated primary site tumor, postoperative recurrence, survival,...
Abstract Purpose Whether or not young patients with squamous cell carcinoma of oral cavity (OC-SCC) have a difference in prognosis remains controversy. This study aimed to analyze the clinical characteristics and survival rates between adult less than 40 years age those older. Methods A retrospective analysis was conducted using database diagnosed OC-SCC 1990 2013 Sun Yat-sen University Cancer Center, but older 85 years, younger 18 died within 6 months diagnosis were excluded. Patients...
Pinato prognostic nutritional index (PNI) adequately predicts long-term outcomes of various malignancies. However, its value in predicting laryngeal squamous cell carcinoma (LSCC) is unknown. All patients newly diagnosed with LSCC presenting to the Department Head and Neck Oncology at Sun Yat-sen University Cancer Center between January 1, 1990 July 31, 2010 were eligible. The PNI was calculated as serum albumin (g/L) + 5 × total lymphocyte count/L. Cutoff Finder software program used...
Aim: The aim of the study was to describe clinical characteristics patients with or without respiratory alkalosis, and analyze relationship alkalosis outcome adult coronavirus disease 2019 (COVID-19) patients. Methods: Clinical laboratory data COVID-19 in a single center China, were retrospectively collected analyzed. Kaplan-Meier (KM) curve cox regression adopted association between prognosis Results: Of 230 patients, 66 (28.7%) had on admission. median age 53 years old (range, 21–84...
CXC chemokine ligand 13 (CXCL13) serves as the for receptor 5 (CXCR5), The CXCL13/CXCR5 signaling axis plays a crucial role in pathogenesis and progression of various malignancies. This study aimed to assess expression serum CXCL13 patients with hepatocellular carcinoma (HCC) explore its clinical significance diagnosis, treatment, prognosis evaluation HCC. Serum samples data were collected from 74 HCC patients, 51 cirrhosis 53 healthy controls. level was measured using enzyme-linked...
To explore the efficacy and side effects of icotinib hydrochloride in treatment patients with advanced non-small cell lung cancer (NSCLC).The 59 cases stage IV NSCIC followed-up from March 2009 to January 2012 were retrospectively analyzed.Twenty seven (45.8%) showed partial response (PR), 17 (28.8%) achieved SD, 15 (25.4%) had progressive disease. The objective rate (ORR) was 45.8% (27/59), disease control (DCR) 74.6% (44/59). Among 23 EGFR mutation, ORR 73.9% (17/23), DCR 95.7% (22/23)....
Abstract Background The purpose of this study was to investigate the clinicopathologic characteristics and prognostic factors second primary tumors (SPTs) in oral cavity patients with nasopharyngeal carcinoma (NPC) after definitive radiation, determine an optimal treatment strategy for these patients. Methods This retrospective enrolled consecutive who were admitted Sun Yat–Sen University Cancer Center between 1990 2005. Results key influencing survival age when NPC diagnosed, TNM stage,...
Pyruvate Kinase Deficiency (PKD) and Crigler-Najjar syndrome are rare autosomal recessive liver diseases. PKD is caused by homozygous or compound heterozygous mutations in the PKLR gene, leading to non-spherocytic hereditary hemolytic anemia. On other hand, (CNS-II) characterized loss reduced activity of UDP-glucuronosyltransferase, resulting elevated levels unconjugated bilirubin, which primary cause disease manifestation. To date, there have been no reported cases patients with both...