A5049885486- Surgical Simulation and Training
- Anatomy and Medical Technology
- Renal Transplantation Outcomes and Treatments
- Augmented Reality Applications
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Simulation-Based Education in Healthcare
- Complement system in diseases
- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Minimally Invasive Surgical Techniques
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Urinary Bladder and Prostate Research
- Genetic and Kidney Cyst Diseases
- Medical Imaging and Pathology Studies
- Renal and related cancers
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Hematopoietic Stem Cell Transplantation
- Peripheral Nerve Disorders
- Urinary Tract Infections Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
Hokkaido University
2019-2025
Hokkaido University Hospital
2020-2024
To seek insights into the pathogenesis of chronic active antibody-mediated rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic component scores graft outcomes.We utilized NanoString nCounter platform Banff Human Organ Transplant gene panel to quantify on 326 archived renal allograft biopsy samples. This system allowed correlation pathology from same tissue block long-term outcomes.The only score that AMR pathways in CAMR was peritubular capillaritis (ptc)....
Abstract Background Our aim was to characterize the motions of multiple laparoscopic surgical instruments among participants with different levels experience in a series wet-lab training drills, which need perform range procedures including grasping tissue, tissue traction and dissection, applying Hem-o-lok clip, suturing/knotting, digitize level competency. Methods Participants performed dissection around aorta, dividing encountered vessels after (Task 1), renal parenchymal closure 2:...
Our aim was to build a skill assessment system, providing objective feedback trainees based on the motion metrics of laparoscopic surgical instruments.Participants performed tissue dissection around aorta (tissue task) and renal parenchymal closure (parenchymal-suturing task), using swine organs in box trainer under capture (Mocap) system. Two experts assessed recorded movies, according formula global operative skills (GOALS: score range, 5-25), mean scores were utilized as variables...
Abstract Chronic active antibody-mediated rejection (CAAMR) is a particular problem in kidney transplantation (KTx), and ~25% of grafts are lost by CAAMR. Further, the pathogenesis remains unclear, there no effective cure or marker. We previously found that hyper NFκB-activating mechanism non-immune cells, called IL-6 amplifier, induced co-activation NFκB STAT3, this activation can develop various chronic inflammatory diseases. Here, we show synaptotagmin-17 (SYT17) increased an exosomal...
Objectives To develop a wet laboratory training model for learning core laparoscopic surgical skills and evaluating learners’ competency level outside the operating room. Methods Participants completed three tasks (task 1: tissue dissection around aorta; task 2: division of renal artery; 3: parenchymal closure). Each performance was video recorded subsequently evaluated by two experts, according to Global Operative Assessment Laparoscopic Skills task‐specific metrics that we developed...
The purpose of this study was to characterize the motion features surgical devices associated with laparoscopic competency and build an automatic skill-credential system in porcine cadaver organ simulation training. Participants performed tissue dissection around aorta, dividing vascular pedicles after applying Hem-o-lok (tissue task) parenchymal closure kidney (suturing task). Movements were tracked by a capture (Mocap) system, Mocap-metrics compared according level experience (experts: ≥50...
This paper presents details of the development and validation a measurement system for laparoscopic surgical procedures. An individual marker set is attached to each instrument, hence developed can simultaneously track multiple instruments. The tracked instruments be exchanged during an operation. movements such as grasping forceps, scissors clip appliers, needle holders are measured, their tip positions, opening ratios, gripper rotation angles, orientations calculated online. Two strain...
Objectives Previous studies suggested that living kidney donors do not have a higher risk of death or failure than the general population. However, donor is controversial. Furthermore, only few evaluated long‐term function after donation. Methods This study Japanese donor' outcomes, including mortality and function. From 1965 to 2015, 230 (76 males, 154 females, median age 54) were enrolled in this study. The observation period was 11.0 (range, 0.3–41.0) years. Results In total, 215 still...
Laparoscopic surgery is a widely used surgical technique, on the other hand, its high degree of difficulty makes it difficult for beginners to learn technique efficiently. In addition, recent working hour restrictions and shortages surgeons have resulted in insufficient training time, establishing efficiently methods becoming urgent needs. Therefore, promote skill proficiency novice surgeons, machine learning-based assessment system laparo-scopic skills was developed. A measurement with...
This study developed and validated a surgical instrument motion measurement system for skill evaluation during practical laparoscopic surgery training. Owing to the various advantages of including minimal invasiveness, this technique has been widely used. However, expert surgeons have insufficient time providing training beginners due shortage limited working hours. Skill transfer efficiency be improved which there is an urgent need develop objective methods. Therefore, simple capture–based...
This paper describes the development and validation of measurement system for laparoscopic surgical procedures in practical surgery training. In order to measure motion instruments a training using cadaver or live animal, capture (MoCap) based simple is developed. Since this has configuration requires only origin definition, it easy install operating room. By attaching individual marker set each instrument, can track multiple simultaneously detect exchange them during Accuracy verification...
This paper describes a measurement system for skill evaluation of laparoscopic surgical procedures. Individual marker sets are attached to grasping forceps, scissors clip applier, and needle holders respectively, hence the developed can detect exchanges instruments. Two one sheath forceps other handle. The opening ratio gripper is estimated by relative distance two sets. A strain gauge measure force during operation. Lymphadenectomy renal parenchyma suturing using organs cadaver pigs were...
Introduction Femoral nerve palsy is a rare but serious complication of kidney transplantation. We report case femoral following transplantation and conduct review the literature on this complication. Case presentation A 35‐year‐old woman with end‐stage disease, underwent in right iliac fossa. The day after transplantation, she could not straighten her leg. Physical examination revealed paresis quadriceps muscle. patient’s sensation thigh was also impaired. diagnosed caused by inappropriate...
Abstract Background Removal of anti-blood group antibodies is important for successful ABO-incompatible kidney transplantation (ABOi-KTx). Double-filtration plasmapheresis (DFPP) using albumin solution removes effectively. However, fibrinogen largely removed resulting in hemostatic failure. Herein, we designed an altered combination plasma membranes DFPP (novel DFPP, nDFPP) to retain more while removing IgG, and assessed its efficacy safety compared with conventional (cDFPP). Methods...
Several cases of kidney transplantation after hematopoietic stem cell (HSCT) from the same donor for end-stage renal disease have been reported. In those cases, immunosuppressive drugs were discontinued since immune tolerance was supposed to be induced. Theoretically, recipient's system recognizes allograft as its own tissue with human leukocyte antigen (HLA) profile, and will not rejected, even without use agents. However, almost all recipients receive immunosuppressants in early stages...
Abstract Although the mRNA SARS-CoV-2 vaccine has improved mortality rate in general population, its efficacy against rapidly mutating virus strains, especially kidney transplant recipients, remains unclear. We examined anti-SARS-CoV-2 spike protein IgG antibody and neutralizing titers cellular immunity B.1.1, BA.1, BA.5 antigens 73 uninfected recipients 16 healthy controls who received three doses of an vaccine. The were significantly lower than controls. Similarly, viral variants...
The Banff Working Group has updated the histological classification of BK virus nephropathy (BKVN), highlighting importance early detection. However, an detection strategy for BKVN using biopsy not yet been established. Our investigation aimed to assess efficacy protocol diagnosis BKVN.
Abstract Introduction We report a case of laparoscopic adrenalectomy in salvage setting after multiple chemotherapies for neuroendocrine carcinoma. Case presentation A 49‐year‐old man was diagnosed with unknown primary carcinoma single brain metastasis, and right supraclavicular mediastinal lymph node metastases. After stereotactic radiotherapy the metastasis systemic chemotherapy, lymphadanectomy performed. The pathologic diagnosis At 11 months surgery, computed tomography revealed adrenal...
Long-term calcineurin inhibitor (CNI) administration causes irreversible nephrotoxicity. Therefore, early CNI-induced nephrotoxicity detection is necessary for patients who will need long-term CNI administration. There no pathological indicator Here, serial protocol kidney biopsy specimens from five kidney-transplant with severe were examined. We observed that the increase in CD44 expression glomerular parietal epithelial cells (PECs) preceded chronic changes of such as tubular...
Our previous study revealed that over 50% of recipients with pretransplant impaired glucose tolerance (IGT) improved to normal after kidney transplantation. However, the mechanism is unclear. We aimed investigate whether changes in are associated β-cell function and insulin resistance Japanese transplant IGT. Of 265 who received transplantation, 54 IGT were included. divided into improvement nonimprovement groups according change area under curve for obtained from oral test (OGTT). β-Cell...
Our aim was to develop practical training for laparoscopic surgery using Thielembalmed cadavers. Furthermore, in order verbalize experts' motion characteristics and provide objective feedback trainees, we initiated capture analyses of multiple surgical instruments simultaneously during the cadaveric trainings. In present study, report our preliminary results.
Tissue handling is one of the pivotal parts surgical procedures. We aimed to elucidate characteristics experts' left-hand during laparoscopic tissue dissection.