A5067637993- Pectus Deformity Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Neuroblastoma Research and Treatments
- Light effects on plants
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Physiological and biochemical adaptations
- Animal Behavior and Reproduction
- Genital Health and Disease
- Enzyme Production and Characterization
- Insect and Arachnid Ecology and Behavior
- Pelvic and Acetabular Injuries
- Congenital Diaphragmatic Hernia Studies
- Algal biology and biofuel production
- Advanced X-ray and CT Imaging
- Image Enhancement Techniques
- Cancer therapeutics and mechanisms
- Advanced Image Processing Techniques
- Cancer, Hypoxia, and Metabolism
- Image and Signal Denoising Methods
- Congenital Anomalies and Fetal Surgery
- Viral gastroenteritis research and epidemiology
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
Beijing Children’s Hospital
2015-2024
Capital Medical University
2015-2024
Janelia Research Campus
2018-2024
Helix (United States)
2021-2024
Zhejiang Chinese Medical University
2023-2024
University of Washington
2018-2024
University College London
2015-2024
University of Massachusetts Chan Medical School
2024
Howard Hughes Medical Institute
2018-2023
Chinese Academy of Sciences
2015-2023
A deraining network can be interpreted as a conditional generator that aims at removing rain streaks from image. Most existing image methods ignore model errors caused by uncertainty reduces embedding quality. Unlike embed low-quality features into the directly, we replace latent high-quality features. The spirit of closed-loop feedback in automatic control field is borrowed to obtain new method for error detection and feature compensation proposed address errors. Extensive experiments on...
To effectively control their bodies, animals rely on feedback from proprioceptive mechanosensory neurons. In the Drosophila leg, different proprioceptor subtypes monitor joint position, movement direction, and vibration. Here, we investigate how these diverse sensory signals are integrated by central circuits. We find that for leg position directional converge in second-order neurons, revealing pathways local of posture. Distinct populations neurons integrate tibia vibration across pairs...
Abstract Daily temporal organisation offers a fitness advantage and is determined by an interplay between environmental rhythms circadian clocks. While light:dark cycles robustly synchronise clocks, it not clear how animals experiencing only weak cues deal with this problem. Like humans, Drosophila originate in sub-Saharan Africa spread North up to the polar circle, long summer days or even constant light (LL). LL disrupts clock function, due activation of CRYPTOCHROME, which induces...
Circadian behaviors need to be properly phased with the day/night cycle beneficial. We previously showed that microRNA miR-124 regulates circadian behavior phase in Drosophila. Here, we report expression during larval development is required for proper phasing of both morning and evening peaks activity adults. Loss results significant miswiring within neural network severely alters rhythms ventral Lateral Neurons (s-LNvs) posterior Dorsal 1 (DN1ps), which control timing activity. Silencing...
Abstract Importance Neuroblastoma is the most common extracranial malignant solid tumor in children. Multidisciplinary care critical to improving survival of pediatric patients with neuroblastoma. Objective To systematically summarize clinical characteristics children neuroblastoma and evaluate their prognosis multidisciplinary provided a single center. Methods This retrospective study analyzed data 1041 who were diagnosed, treated, followed‐up Hematology‐Oncology Center Beijing Children’s...
A Gram-stain-negative, non-motile, non-spore-forming, long rod-shaped bacterium, designated strain GYP-15 T , was isolated from the culture broth of a marine microalga, Picochloruma sp. 122. Phylogenetic analyses revealed that shared 90.6 % 16S rRNA gene sequence similarity with its closest relative, Kangiella aquimarina KCTC 12183 and represents distinct phylogenetic lineage in robust clade consisting members genera Pleionea order Oceanospirillales . Chemotaxonomic physiological...
Noroviruses (NoVs) are the main cause of acute gastroenteritis in all ages worldwide. The aim this study was to produce recombinant P protein norovirus and demonstrate its blocking effect. In study, engineered strains were induced express NoVs GII.4, which identified using SDS-PAGE ELISA as having capacity bind histo-blood group antigens (HBGAs). Rabbits immunized obtain neutralizing antibodies. ISC-RT-qPCR used determine efficacy antibody human (HuNoV) murine (MNV). (35 KD) obtained,...
Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene ( AIP ) predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose difficulties for genetic counselling and family follow-up. Objective To develop an viv o system test human using fruit fly Drosophila melanogaster . Methods We generated a null mutant orthologue, CG1847, located on Xchromosome, which displayed lethality at larval stage...
A Gram-stain-negative, yellow, non-spore-forming, strictly aerobic bacterium, designated C3T, was isolated from a cyanobacterial culture pond. Cells were halophilic, rod-shaped and able to move by gliding. Growth of strain C3T observed at 15-30 °C (optimum 25 °C), pH 6.0-9.0 7.5), in the presence 1-7 % (w/v) NaCl 2-3 %). Phylogenetic analysis based on 16S rRNA gene sequences revealed that formed distinct lineage within family Flavobacteriaceae exhibited highest similarity (95.21 %) type...
Mediastinal teratoma is uncommon in children. It can be very difficult to diagnose especially early stage. Rarely, may rupture into adjacent structures and lead lung lesions or pleuritis. The main rarity of our reported cases was the dynamic imaging findings similar developmental process tuberculosis patients 1 2, pachypleuritis 2 3, extremely elevated inflammatory markers empyema patient atypical tumor shape all patients. We present three pediatric presenting predominantly with recurrent...
A Gram-stain-negative, aerobic bacterium, designated strain GYP-11T, was isolated from the culture broth of a marine microalga, Picochloruma sp. 122. Cells were dimorphic rods; free living cells motile by means single polar flagellum, and star-shaped-aggregate-forming attached with stalks non-motile. Sodium pyruvate or Tween 20 required for growth on agar 2216.16S rRNA gene sequence analysis revealed that this isolate shared 94.07 % similarity its closest type strain, Parvibaculum...
ABSTRACT The insect central complex and vertebrate basal ganglia are forebrain centres involved in selection maintenance of behavioural actions. However, little is known about the formation underlying circuits, or how they integrate sensory information for motor Here, we show that paired embryonic neuroblasts generate ring neurons mediate sensory-motor transformation action Drosophila. Lineage analysis resolves four neuron subtypes, R1-R4, form GABAergic inhibition circuitry among inhibitory...
Abstract CT has become a routine imaging modality based on its excellent ability of displaying lung structures and diseases. But, how to reduce radiation dose examination is concern for radiologists. Our study aimed evaluate the feasibility using 80kVp model-based iterative reconstruction (MBIR) algorithm achieve one-tenth mSv chest in infants young children. Thirty-two cases (study group, average age 1.71 ± 1.01 years) underwent non-contrast at low with 80 kV, 4mAs was reconstructed MBIR...
Increasing evidence suggests that long non-coding RNAs (lncRNAs) are involved in neuroblastoma (NB) pathogenesis. The aim of this study was to elucidate the roles and underlying mechanism RNA activated by DNA damage (NORAD) childhood NB. Both public data clinical specimens were used determine NORAD expression. Colony formation, cell proliferation wound healing assays performed evaluate effects on migration SH-SY5Y SK-N-BE(2) cells. Flow cytometry examine cycle changes. expression genes...
A Gram-stain-negative, non-motile, non-spore-forming, rod-shaped bacterium, designated strain GYP-24T, was isolated from the culture broth of a marine microalga, Picochlorum sp. 122. Phylogenetic analyses based on 16S rRNA gene sequences indicated that GYP-24T forms robust cluster with H.wangdoniaseohaensis KCTC 32177T (95.8 % sequence similarity) in family Flavobacteriaceae. Growth observed at 15, 22, 28, 30, 33 and 37 °C (optimal 30-33 °C), pH 6.0-10.0 7.0-8.0) presence 0.5-4 (w/v) NaCl...