A5057381790- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
Hospital Universitario Fundación Jiménez Díaz
2025
Neurological Surgery
2025
Hospital Universitario Son Espases
2025
Health Research Institute of the Balearic Islands
2021-2025
Introduction: 5-aminolevulinic acid (5-ALA) fluorescence used in glioma surgery has different intensities within tumors and among patients, some molecular external factors have been implicated, but there is no clear evidence analyzing the difference of according to characteristics. This study aimed compare samples with intensity identify potential cofounders associations clinically relevant tumor features. Methods: Tumor high-grade patients operated using 5-ALA for guided resection were...
Importance Triple-negative breast cancer (TNBC) is the most aggressive subtype and appears to have disproportionately higher incidence worse outcomes among younger African American females. Objective To investigate whether epigenetic differences exist in TNBCs of females that may explain clinical disparities seen this patient group. Design, Setting, Participants This cross-sectional study used clinical, demographic, DNA methylation (HumanMethylation450; Illumina), gene expression (RNA...
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which first step metastatic process. Methods We combined RNA expression chromatin interaction data identify insulator elements potentially associated with MMP gene invasion. employed CRISPR/Cas9 disrupt...
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and median overall survival of less than two years. Over last decade, numerous findings regarding distinct molecular genetic profiles GBM have led to emergence several therapeutic approaches. Unfortunately, none them has proven be effective against progression recurrence. Epigenetic mechanisms underlying tumor biology, including histone modifications, DNA methylation, chromatin architecture,...
Abstract Background Glioblastoma (GBM) is the most aggressive and prevalent primary brain tumor, with a median survival of 15 months. Advancements in multi-omics profiling combined computational algorithms have unraveled existence three GBM molecular subtypes (Classical, Mesenchymal, Proneural) clinical relevance. However, due to costs high-throughput techniques, subtyping not currently employed settings. Methods Using Random Forest Nearest Shrunken Centroid algorithms, we constructed...
Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does not respond to treatment. Biomarkers that show ICI predictive potential other solid tumors, such as levels PD-L1 and the tumor mutational burden, among others, modest performance with TNBC.We built machine learning models based on pre-ICI treatment gene expression profiles construct classifiers identify primary TNBC ICI-responder This study...
Glioma stem cells (GSCs) have self-renewal and tumor-initiating capacities involved in drug resistance immune evasion mechanisms glioblastoma (GBM).Core-GSCs (c-GSCs) were identified by selecting co-expressing high levels of embryonic cell (ESC) markers from a single-cell RNA-seq patient-derived GBM dataset (n = 28). Induced c-GSCs (ic-GSCs) generated reprogramming GBM-derived (GBM-DCs) using induced pluripotent (iPSC) technology. The characterization ic-GSCs GBM-DCs was conducted...
Abstract Objectives Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited treatment options. Unlike other subtypes, the scarcity of specific therapies and greater frequencies distant metastases contribute to its aggressiveness. We aimed find epigenetic changes that aid in understanding dissemination process these cancers. Data description Using CRISPR/Cas9, our experimental approach led us identify disrupt an insulator element, IE8, whose activity seemed relevant...
<title>Abstract</title> <bold>The intensity of </bold>5-ALA fluorescence used in glioma surgery varies within tumors, and among different patients, several molecular external factors have been implicated; however, there is no clear evidence analysing the difference according to characteristics. This study aimed compare samples with identify potential cofounders associations clinically relevant tumor features. Tumor from high-grade patients treated 5-ALA for guided resection were included...
Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome may contribute to matrix metalloprotease (MMP) dysregulation given their key role in invasion, which first step metastatic process. Methods We combined RNA expression chromatin interaction data identify insulator elements potentially associated with invasion. stably disrupted...
Abstract Glioma stem cells (GSCs) are a subset of with self-renewal and tumor-initiating capacities that thought to participate in drug resistance immune evasion mechanisms glioblastoma (GBM). Given GBM heterogeneity, we hypothesized GSCs might also display cellular hierarchies associated different degrees stemness. We evaluated single-cell RNA-seq dataset ( n = 28) identified cell population co-expressing high levels embryonic pluripotency markers, named core glioma (c-GSCs). This...