A5041009433- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Curcumin's Biomedical Applications
- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Exercise and Physiological Responses
- Genetics and Neurodevelopmental Disorders
- Histone Deacetylase Inhibitors Research
- Adipose Tissue and Metabolism
Nanjing University
2022-2024
State Key Laboratory of Analytical Chemistry for Life Science
2022
Cachexia is characterized by progressive weight loss accompanied the of specific skeletal muscle and adipose tissue. Increased lactate production, either due to Warburg effect from tumors or accelerated glycolysis effects cachectic muscle, most dangerous factor for cancer cachexia. This study aimed explore efficiency 2-deoxy-D-glucose (2-DG) in blocking Cori cycle activity its therapeutic on cachexia-associated wasting. A C26 adenocarcinoma xenograft model was used metabolic derangements....
Cancer cachexia is a multifactorial syndrome defined by progressive loss of body weight with specific depletion skeletal muscle and adipose tissue. Since there are no FDA-approved drugs that available, nutritional intervention recommended as supporting therapy. Creatine supplementation has an ergogenic effect in various types sports training, but the regulatory effects creatine cancer remain unknown. In this study, we investigated impact on cachectic protection tumor-bearing mouse model,...